DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17717 and MARCHF7

DIOPT Version :9

Sequence 1:	NP_572327.1	Gene:	CG17717 / 31592	FlyBaseID:	FBgn0029877	Length:	266	Species:	Drosophila melanogaster
Sequence 2:	NP_001269734.1	Gene:	MARCHF7 / 64844	HGNCID:	17393	Length:	704	Species:	Homo sapiens

Alignment Length:	183	Identity:	41/183 - (22%)
Similarity:	76/183 - (41%)	Gaps:	18/183 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AQPP---QSAAAEAICSSQIVASAHGTPTASTAALEISSARQRMLRSHLQESL---HSANESGNS 90
            |.||   .:.....:.:..|:.|...:....:...:.:.:|.......::|||   .|..|.|:.
Human   487 AVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDL 551

  Fly    91 CRICRW-NRNDMEIIKCPCNCKGSVGYIHLKCLKRWIMHRRDN--------RCEICNAVFNIAEE 146
            ||||:. ..:...::..||.|.||:.|:|..|:|:|:..:.::        .||:|.....:..|
Human   552 CRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLE 616

  Fly   147 RASLKQMIRTFCCGRCCGLIVKHLLFSASLMPLAHIILQQVLQCMDNMNQGST 199
            ...:.::.|.....:.....:...|:   |:.|.|:..|.....|.|.|:.||
Human   617 DFDIHELHRAHANEQAEYEFISSGLY---LVVLLHLCEQSFSDMMGNTNEPST 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17717	NP_572327.1	RINGv	91..138	CDD:128983	16/55 (29%)
MARCHF7	NP_001269734.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..279
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..313
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..343
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..425
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..473
		RING_Ubox	552..610	CDD:388418	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..704
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R328
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840