DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf128 and APE3

DIOPT Version :9

Sequence 1:	NP_001166820.1	Gene:	Rnf128 / 315911	RGDID:	1566282	Length:	428	Species:	Rattus norvegicus
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	258	Identity:	53/258 - (20%)
Similarity:	86/258 - (33%)	Gaps:	97/258 - (37%)

- Green bases have known domain annotations that are detailed below.

  Rat    29 LSPHAPGSRGAEAV---------WTAYLNVSWRVP---HP-------GVNRTVWELSEEGVYGQD 74
            :.||....:..:.:         |..|...::..|   ||       |.|:|:..:.......||
Yeast    66 MKPHVESEKLQDKIKVDDLNATAWDLYRLANYSTPDYGHPTRVIGSKGHNKTMEYILNVFDDMQD 130

  Rat    75 ------SPLEPVSGVLVPPDGPGALNACNPHT--NFTVPTVW----------GSTVQV------- 114
                  ...|.:||.::      :.|..:..|  :|...|.:          |..|::
Yeast   131 YYDVSLQEFEALSGKII------SFNLSDAETGKSFANTTAFALSPPVDGFVGKLVEIPNLGCEE 189

  Rat   115 -------------SWLALIQRGGGCTFADKIHLAYERGASGAVIF-NFP-------GTRNEVIPM 158
                         ..:|||:| |.|.|.||.:||.:.|.:..||: |.|       ||..|  |.
Yeast   190 KDYASVVPPRHNEKQIALIER-GKCPFGDKSNLAGKFGFTAVVIYDNEPKSKEGLHGTLGE--PT 251

  Rat   159 SHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSF--FIIT 219
            .|    .:..:.:....|.|::.:|...|.                 ||::|...|:  ||.|
Yeast   252 KH----TVATVGVPYKVGKKLIANIALNID-----------------YSLYFAMDSYVEFIKT 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf128	NP_001166820.1	PA_GRAIL_like	48..193	CDD:239037	42/200 (21%)
Rnf128	NP_001166820.1	zf-RING_2	275..318	CDD:290367
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	51/246 (21%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045	33/152 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910