DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf128 and rnf128a

DIOPT Version :9

Sequence 1:	NP_001166820.1	Gene:	Rnf128 / 315911	RGDID:	1566282	Length:	428	Species:	Rattus norvegicus
Sequence 2:	NP_997780.1	Gene:	rnf128a / 322325	ZFINID:	ZDB-GENE-030131-1044	Length:	389	Species:	Danio rerio

Alignment Length:	409	Identity:	212/409 - (51%)
Similarity:	265/409 - (64%)	Gaps:	37/409 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    13 GGCGAARLLAWCFLLALSPHAPGSRGAEAVW--TAYLNVSWRVPHPGVNRTVWELSEEGVYGQDS 75
            |...:..:.:| .|||........|.|||.:  |||||:|:  .:|..||:.|...|.|:|||||
Zfish     2 GPLASRDVFSW-LLLASVLQVSSVRLAEASYLCTAYLNISY--TNPENNRSTWFQEEMGLYGQDS 63

  Rat    76 PLEPVSG--VLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYER 138
            |...|.|  .|..|     ...|:..|.:..|.  ||.   .|:||||||.||||.:||::|...
Zfish    64 PKAYVKGNVYLASP-----TYGCDDDTFYGRPN--GSK---GWIALIQRGNGCTFTEKINIAAMN 118

  Rat   139 GASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWV 203
            ||:.|:|||..|:.|.||.|||||. .||||||||.:|.:::|.:.:|:.|.:.|||||:||||:
Zfish   119 GAAAAIIFNDFGSENRVIQMSHPGT-TIVAIMIGNYRGMELVQLLDQGVPVAIAIEVGKQHGPWM 182

  Rat   204 NHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDK 268
            :|||:||||:||||:||||||||||||||||.:.|.|:|.|::|||:||||||:||:|||:|||:
Zfish   183 SHYSVFFVSISFFIVTAATVGYFIFYSARRLNSLRQQNRSQKKLKAEAKKAIGQLQVRTLRQGDQ 247

  Rat   269 EIGPDGDSCAVCIELYKPNDVVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVED 333
            |||||.|:|||||:.||..||:.||||||.|||:|::|||||||||||||||||||||:|:|||:
Zfish   248 EIGPDADACAVCIDSYKAGDVLSILTCNHFFHKSCIEPWLLEHRTCPMCKCDILKALGVELDVEE 312

  Rat   334 GSVSLQVPVSNEASNTASPHEE---DNRSETASSGYASVQGADEPPLEEHAQSANENLQLVNHEA 395
             ...:.||.....|.:...|.|   ...||||||||||:.|      .||         |...|.
Zfish   313 -QPQISVPDFRPFSTSEDLHSETASHTHSETASSGYASMHG------NEH---------LAPPEG 361

  Rat   396 NSVAVDVVPHVDNPTFEED 414
            ....|...||.||..||.|
Zfish   362 THNGVQEEPHYDNLAFESD 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf128	NP_001166820.1	PA_GRAIL_like	48..193	CDD:239037	64/146 (44%)
Rnf128	NP_001166820.1	zf-RING_2	275..318	CDD:290367	31/42 (74%)
rnf128a	NP_997780.1	PA_GRAIL_like	38..172	CDD:239037	64/146 (44%)
rnf128a	NP_997780.1	zf-RING_2	256..297	CDD:290367	30/40 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194886649
Domainoid	1	1.000	146	1.000	Domainoid score	I17512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11337
Inparanoid	1	1.050	378	1.000	Inparanoid score	I7911
OMA	1	1.010	-	-		QHG39235
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0011956
OrthoInspector	1	1.000	-	-		otm31803
orthoMCL	1	0.900	-	-		OOG6_115655
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910