Protein Alignment CG34417 and SPECC1

DIOPT Version :9

• Sequence 1: NP_001259282.1
• Gene: CG34417 / 31591
• FlyBaseID: FBgn0085446
• Length: 5182
• Species: Drosophila melanogaster
• Sequence 2: XP_016880808.1
• Gene: SPECC1 / 92521
• HGNCID: 30615
• Length: 1076
• Species: Homo sapiens
• Alignment Length: 1249
• Identity: 259/1249 - (20%)
• Similarity: 424/1249 - (33%)
• Gaps: 413/1249 - (33%)

  Fly  4041 PR---SATTYSNTPSPSSTATSPIGLPWVAKPKVDNSDFRRKAHHFEERSLRDNIEQQQQPTYPN 4102
            ||   |:.|.||||:|:....:|     ..|||.:|....:.|...:.|.|....:.:....
Human   128 PRKSVSSPTSSNTPTPTKHLRTP-----STKPKQENEGGEKAALESQVRELLAEAKAKDSEI--- 184

  Fly  4103 GNNGYLQRHNSLRSKAPALSEFKKRPSL----PNAMDP---GTAAPPRQVYQAPPPPTNISFTYA 4160
                     |.|||:   |.::|::.:|    .:|:.|   ||:..|                 .
Human   185 ---------NRLRSE---LKKYKEKRTLNAEGTDALGPNVDGTSVSP-----------------G 220

  Fly  4161 DFPPVRRPQGASAHNYRSQPCLTSAVDQVEALTNPLGAPLVLTSSNPTYLPPPGSRRFDYISS-P 4224
            |..|:.|.......|::.:      :..:|.....|...|:....:|.   ..|:......|| |
Human   221 DTEPMIRALEEKNKNFQKE------LSDLEEENRVLKEKLIYLEHSPN---SEGAASHTGDSSCP 276

  Fly  4225 VDVDADSPPNSPTSFMTMPNPTLMTDNTDDDLDLDSDNNMLEYRAETKVMRKPRSQTAVRVADRR 4289
            ..:..:|...|||.           :....|:|        ||                    ::
Human   277 TSITQESSFGSPTG-----------NQMSSDID--------EY--------------------KK 302

  Fly  4290 NAHMSDDEVYGKNSRAAKSLLYTMKQLGGGPGNASVGNSGQRRQPLTAPSSPKSGCLSPDGRPYQ 4354
            |.|                            ||| :..||.....:|..|      ||||...::
Human   303 NIH----------------------------GNA-LRTSGSSSSDVTKAS------LSPDASDFE 332

  Fly  4355 APLVE-PLFPQLSTFEPKRQPQFANSPMST----PPAVSMPSINYQANPTYTPPRSNQNSNSYLG 4414
            ....| |..|..||..|     |.:|..||    |.:||..|:   |:.|....:..:|.:|...
Human   333 HITAETPSRPLSSTSNP-----FKSSKCSTAGSSPNSVSELSL---ASLTEKIQKMEENHHSTAE 389

  Fly  4415 ETNTSYVVTYPLDDSGDEPEPESMATSVSQRLRRTSEHSNASSSLSLGSTSWTANPVHNTVPSVP 4479
            |...:      |.:..|:.:.....|:.:::|
Human   390 ELQAT------LQELSDQQQMVQELTAENEKL--------------------------------- 415

  Fly  4480 LDSAMGPPVDRSTKPQVSQPVGPKMPQHVAQKQIPQQLPNQLPQQIPQQLPK-------QLPQQI 4537
                    ||..|..:.|.....:..:.::|:.  ::|.|.|.:::..:.|.       :|.|:.
Human   416 --------VDEKTILETSFHQHRERAEQLSQEN--EKLMNLLQERVKNEEPTTQEGKIIELEQKC 470

  Fly  4538 PQQLPQ-QLPQQLPKQLPQQIPPQLPKQLPQQIPQPELPQQLPN---------NLPRH-----AP 4587
            ...|.| :..::....:.||:...|.|...:.....|:.::|..         .|.||     |.
Human   471 TGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAK 535

  Fly  4588 KLSSRSHTIQGDSGYENRPLQNRVMSQQ---TLNSSIITSNNHTTVQKQQK---------EQHIN 4640
            .|.....|::| ...||..|::.:..::   |..|::..:.....||:..|         |...|
Human   536 TLEECRVTLEG-LKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCN 599

  Fly  4641 ELRRKSLGNVLESSQRSTYFEQEYKSSAPPDTPDIVKSSLPKEDAPLLKKFGPPQRHHYMPNSYQ 4705
            |||::.|....|....|:...:..:.|          |.|.::|...||:.          ..:|
Human   600 ELRQELLKANGEIKHVSSLLAKVRRDS----------SLLVEKDYSYLKEI----------CDHQ 644

  Fly  4706 SPQLN----KQGNSNSTTTSSTSVRSTTVVQQQHHQQQHQQIKPSIVETPATPQPQVPPEDEIPH 4766
            :.||:    |.....|.:.:.......|:.:.:...:||:.:|
Human   645 AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVK---------------------- 687

  Fly  4767 NIVFNN--VSAFTSMSRRNHEEDSHQGTQSGSRVNRL-SKCDSWNQI---------------CQL 4813
              :.||  :|...|...:..|:.|....|..:...:: .:.:.|.:.               |:.
Human   688 --LHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA 750

  Fly  4814 QQTAGPSPAKYNQPGSPGELRRTKSGHSLAVPKLYEAGIDKAQVSEKQRTVAAY---FSGQKSPT 4875
            ||                |||..|.       ||.|.....|::.::...|..:   .:.:.:|.
Human   751 QQ----------------ELRTVKR-------KLLEEEEKNARLQKELGDVQGHGRVVTSRAAPP 792

  Fly  4876 GGQVEELRTSMTTTTSSR--KSAINRTKTSEKLSAAARKSLSSLTTTSNGNVSTAGLGMVVRGGG 4938
              .|:|...|.....:.|  ...::||..:...||...|||          :.:..||   |.||
Human   793 --PVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSL----------IKSFDLG---RPGG 842

  Fly  4939 VG--------------GI----GGGAALS---RSATMPHIANLNLLDESNVEDA----FEQLMMA 4978
            .|              ||    ...||:|   |.:|.           |:|..|    .::|.:.
Human   843 AGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTY-----------SSVRPASRGVTQRLDLP 896

  Fly  4979 QHKSSSSSEQRTETKSKDGGATVTTTTTKVT---------TRTVSGSAASKNISPLAKFKQLDKQ 5034
            ....|...:.||||...|.....:.:...::         ||.:  ||:::...|.:|.
Human   897 DLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLL--SASTRAWKPQSKL------ 953

  Fly  5035 AAAQQAQKSSPTTSTPTTPGGSAQPLFKFTDPALNARAATVKDQLLQWCKHKTQEYENVQINNFS 5099
                ..::..|..:.....|||.                  ::.||:||:.|||.|.|:.|.|||
Human   954 ----SVERKDPLAALAREYGGSK------------------RNALLKWCQKKTQGYANIDITNFS 996

  Fly  5100 SSWSDGLAFCALIHHFLPDAFDYTTLTKQTRRHNFELAFSVADEKAGIAPLLDVEDMVEMSRPDW 5164
            ||||||||||||:|.:||....|..|..|.::.|..|||..| |..||.|.|::.:|:...||||
Human   997 SSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAA-ESVGIKPSLELSEMLYTDRPDW 1060

  Fly  5165 KCVFVYVQSIYRRF 5178
            :.|..||..||:.|
Human  1061 QSVMQYVAQIYKYF 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981	52/103 (50%)
SPECC1	XP_016880808.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910