DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and CHS5

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_013434.1	Gene:	CHS5 / 851041	SGDID:	S000004322	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	703	Identity:	143/703 - (20%)
Similarity:	257/703 - (36%)	Gaps:	169/703 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1736 IIDHMAPKSPKTERRSQGGTGNVPSPIRKLPVTERKESAPVPRVTRRDKAEKVTRST---SENII 1797
            ||.....::.:.|::.:....::.:.|.:...|.:.|| ||.::.      .||:::   :.:.:
Yeast    44 IIKMQVSQNLEEEKKQRNHFKSIQAKILEKYGTHKPES-PVLKIV------NVTQTSCVLAWDPL 101

  Fly  1798 KMSGTKPHPEMSS--LKPGGDRS----RPSKCCTTKTINLSEQ---------------------- 1834
            |:...|    :.|  |...|.||    .|.|..|||...||..
Yeast   102 KLGSAK----LKSLILYRKGIRSMVIPNPFKVTTTKISGLSVDTPYEFQLKLITTSGTLWSEKVI 162

  Fly  1835 -RINTATDIEGVIIDIQQAKSSREPSPDRIV---------PTPVPAELETGKPRYPDVVQEPDDE 1889
             |.:..||:.|:.:.:......:|.|..:|.         |......::|......|:..|..:|
Yeast   163 LRTHKMTDMSGITVCLGPLDPLKEISDLQISQCLSHIGARPLQRHVAIDTTHFVCNDLDNEESNE 227

  Fly  1890 PRRKPQVTNIPIFEEESQTYV-GCQISE-LHSSNGIEVD----ILDNPTVEAPKSLDYPVNTPDT 1948
            ...:.:..||||...|   :| .|::.: :....|..:|    ||.|.|..       |||
Yeast   228 ELIRAKHNNIPIVRPE---WVRACEVEKRIVGVRGFYLDADQSILKNYTFP-------PVN---- 278

  Fly  1949 DESLLSVHEKVSRFTHSAEKVKEPKVSAPFSREFDVNAKIPENDDCLLSINQKVDKFLRTAENVI 2013
                             .|::...|.:.|.:...|.| |:||:       ...|::.....:|..
Yeast   279 -----------------EEELSYSKENEPVAEVADEN-KMPED-------TTDVEQVASPNDNES 318

  Fly  2014 RPTSLPSRPEIERPGLEEIDEELLRDDCTLSVSQKVHKFIDTAEKLAPTMPQKSPRLVANIERHI 2078
            .|:.  ::.:.|:.|.|......:.|....|.:.:....|:|......:: :..|....|||.:.
Yeast   319 NPSE--AKEQGEKSGHETAPVSPVEDPLHASTALENETTIETVNPSVRSL-KSEPVGTPNIEENK 380

  Fly  2079 SRQS------EP-----ERELDEESEPELDRDTDVEDDDQTSQ--LETEEEITQTVTKKETLKEF 2130
            :..|      ||     |...:||:..:...|||...::|...  ::|||.....:|
Yeast   381 ADSSAEAVVEEPNEAVAESSPNEEATGQKSEDTDTHSNEQADNGFVQTEEVAENNIT-------- 437

  Fly  2131 KQQTKETRETRRDSKAE---PEKLQKKSPQTKVKEESARVPKYQAKVSQKVSQWEPKKQPQREPK 2192
            .:...|..|...|:..|   || .:.::|:.....|.|..|...:.        ||.:...:..|
Yeast   438 TESAGENNEPADDAAMEFGRPE-AEIETPEVNESIEDANEPAEDSN--------EPVEDSNKPVK 493

  Fly  2193 VTQKETPLEPKKQPLSKVKDEPEKVNKREPKVPQKESQTKLKEEPERVTKKTPQKEPRKEPLRQS 2257
            .:.|  |:|...:|:       |..||     |.::|...:::..|.|...:...|...||::::
Yeast   494 DSNK--PVEDSNKPV-------EDSNK-----PVEDSNKPVEDANEPVEDTSEPVEDAGEPVQET 544

  Fly  2258 EDEPEF-----SP---EEEFDDEPLPMTKTHTTAIEMKRQKDILNRPSVFGQRTPE-----RKSS 2309
            .   ||     ||   ||:.:.|..|...|.:.|:|...: |:  :|...|....:     .|.:
Yeast   545 N---EFTTDIASPRHQEEDIELEAEPKDATESVAVEPSNE-DV--KPEEKGSEAEDDINNVSKEA 603

  Fly  2310 TTPSPTKLNGTRGRPSPSTNLITEEKRSYRNQVTN---VSKPGTRKTTPSANS 2359
            .:...|....|....|..::.:|||:.:...:|..   :|....:|.|.::||
Yeast   604 ASGESTTHQKTEASASLESSAVTEEQETTEAEVNTDDVLSTKEAKKNTGNSNS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
CHS5	NP_013434.1	Chs5_N	4..76	CDD:260117	4/31 (13%)
		fn3_2	77..165	CDD:407129	20/98 (20%)
		BRCT_CHS5_like	172..255	CDD:349373	16/85 (19%)
		MDN1	<366..607	CDD:227596	60/278 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900