DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and Smtnl1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_077192.1	Gene:	Smtnl1 / 68678	MGIID:	1915928	Length:	459	Species:	Mus musculus

Alignment Length:	462	Identity:	134/462 - (29%)
Similarity:	196/462 - (42%)	Gaps:	118/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  4786 EDSHQGTQSGSRVNRLSKCDSWNQICQLQQTAGPSPAKYNQPGSPG------ELRRTKSGHSLAV 4844
            |:..:||...|  ::....|....:|:....:|.|      .||||      ||:....|.:
Mouse    32 EEVAEGTVGTS--DKEGPSDWAEHLCKAASKSGES------GGSPGEASILDELKTDLQGEA--- 85

  Fly  4845 PKLYEAGIDKAQ-------VSEKQRTVAAY-FSGQK---SPTGGQVEELRTSM------------ 4886
                 .|.|:||       |.::..|.|:. .:|:|   .|...:|.|...:|
Mouse    86 -----RGKDEAQGDLAEEKVGKEDTTAASQEDTGKKEETKPEPNEVREKEEAMLASEKQKVDEKE 145

  Fly  4887 TTTTSSRKSAIN-RTKTSEKLSAAARKSLSSLTTTSNGNVSTAGLGMVVRGGGVGGIGGGAALSR 4950
            |...|..||.:| :.|...|..|.|..:::...|.|......                      :
Mouse   146 TNLESKEKSDVNDKAKPEPKEDAGAEVTVNEAETESQEEADV----------------------K 188

  Fly  4951 SATMPHIANLN----------LLD-ESNVEDAFEQLMMAQHKSS-------SSSEQRTETKSKDG 4997
            ....|.:..::          |:: ||..|   ||....:::|.       ||.|:..|:.:.:|
Mouse   189 DQAKPELPEVDGKETGSDTKELVEPESPTE---EQEQGKENESEERAAVIPSSPEEWPESPTDEG 250

  Fly  4998 GATVTTTTTKVTTRTVSGSAASKNIS--------PLAKFKQLDKQAAAQQAQKSSPTTSTPTTP- 5053
            .:.........:|...|.||:..:.|        |....|:.|:   |.:.:.|:|  |.|..|
Mouse   251 PSLSPDGLAPESTGETSPSASESSPSEVPGSPTEPQPSEKKKDR---APERRVSAP--SRPRGPR 310

  Fly  5054 -----------GGSAQ---PLFKFTDPALNARAATVKDQLLQWCKHKTQEYENVQINNFSSSWSD 5104
                       ||:|.   .||:.| .|..|....||:.||:||:..|:.||:|.|.|||||||.
Mouse   311 AQNRKAIMDKFGGAASGPTALFRNT-KAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSS 374

  Fly  5105 GLAFCALIHHFLPDAFDYTTLTKQTRRHNFELAFSVADEKAGIAPLLDVEDMVEMSRPDWKCVFV 5169
            |:|||||||.|.|:||||..|....|||||.||||.|::.|..|.||:|:|||.::.||.|||:.
Mouse   375 GMAFCALIHKFFPEAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYT 439

  Fly  5170 YVQSIYR 5176
            |:|.:||
Mouse   440 YIQELYR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981	59/101 (58%)
Smtnl1	NP_077192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..314		66/327 (20%)
		MDN1	<51..229	CDD:227596	41/216 (19%)
		PTZ00449	<150..>310	CDD:185628	36/189 (19%)
		CH	345..446	CDD:366016	58/100 (58%)
		Calmodulin-binding	441..459		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4987
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001328
OrthoInspector	1	1.000	-	-		otm43286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840