DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34417 and Rp1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	XP_008761780.1	Gene:	Rp1 / 681377	RGDID:	1596713	Length:	2150	Species:	Rattus norvegicus

Alignment Length:	2418	Identity:	438/2418 - (18%)
Similarity:	710/2418 - (29%)	Gaps:	899/2418 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1329 SHTTIETIQVKIEDCPN---------DDEDDKPRR---VTETYVVRTQPKIKVEEELFVDVTEAE 1381
            |:..:..:..|:.:.|:         ..|...|.|   ||...|.:.....|..:..|      .
  Rat    15 SNIFLSKVSSKMSETPSTSFSMIRLTSSEGQVPSRHSNVTHPTVAKRISFYKSGDPQF------G 73

  Fly  1382 DVEILVNP-------------SKKSPKEEDSPKYPKGPETPKSPRNDQRIPSIP--KKGQS---- 1427
            .|.::|||             |:|.|       .|.|.....:||....|..:.  :.|:|
  Rat    74 GVRVVVNPRSFKTFDALLDNLSRKVP-------LPFGVRNISTPRGRHSITKLEELEDGESYVCS 131

  Fly  1428 ------PVQF-KTEETPRYPQEQER-----YPKEPETSQYPKESP---RNPKEDAETININEETT 1477
                  ||.. |....|| |....|     ......|:..|..:|   |.|:.
  Rat   132 HNKKVLPVDLDKARRRPR-PWLSSRSISTHVKLRSATATMPTTAPGLFRAPRR------------ 183

  Fly  1478 IVITKEGSKSPSPRWSPSPERRVPKS---------QQPPSPTASPSVSPVSGRKIPN-------- 1525
            :|:.:.|  .|..|......||:.:|         |....|.|  .:....|||:|:
  Rat   184 LVVFRNG--DPKTRRVVLLSRRITQSFEAFLQYLTQVMQYPVA--KLYATDGRKVPSLQAVILSS 244

  Fly  1526 ----------------EVESNFVTEKI------IDCRGKTVVEKISQRPRTPSPTTPKKNTKPSQ 1568
                            :::...:..|:      :..:||..:||  ::..|.|...|:.::..|:
  Rat   245 GAVVAAGREPFKPGNYDIQKYLLPVKLPGISHRVHRKGKAKIEK--RKMSTHSVPRPQTDSLASE 307

  Fly  1569 KIPERVPETESEPEKDSESETKKTTSVSVTKTETERRNS-------------------------- 1607
            |..:...:....||.....||..:.::|...:|.....|
  Rat   308 KTYDCFSDFSVAPENYLALETHDSQTLSTYPSEDGVEKSIVFNQDGTMTVVMKVRFKIKEETVKW 372

  Fly  1608 RTTKTKQPLPLKEPQSKV---PAGKSPRKDSLTGRKRDSLVEETRITTTTTTTRQGRKPSDTNGS 1669
            .||..:..|...:.:||:   |.....|..||......||.|:     .|.||:||....:.|..
  Rat   373 TTTVNRADLSNDDEKSKISSYPGKTEDRSSSLKLVVPCSLSED-----ITDTTQQGSLTEEENTQ 432

  Fly  1670 PSIKDRLRSSPR-------------KQKTSPQQTRTPTPAQTR-NPEDDVDGDSSSPDASPTRV- 1719
            .:.:..|.||..             .||......|.|||...| ..:..|.|..:.  .|.|.|
  Rat   433 MTEQQALSSSSAGWENASMEVGIQGSQKQVKHFYRPPTPGPRRMRQKKSVIGTVTV--VSETEVQ 495

  Fly  1720 ------GNERRRSSNISVHTEIIIDHMAPKSPKTERRSQGGTGNVPSPIRKLPVTER-KESAPVP 1777
                  ..||........|   :..|...|......:    ...:.|...:....|| |||.|:
  Rat   496 EKQFSYREEREVGEKSKYH---MFTHSCSKMSSVSNK----LVQISSDDERESALERTKESGPL- 552

  Fly  1778 RVTRRDKAEKVTRS----TSENIIKMSGTKPH--------PEMSSLKPGGDRSRPSKCCTTKTI- 1829
                  |:..:...    ||:.::||.    |        ||.|.::.|.|.|..|...|.|..
  Rat   553 ------KSHAINAGAIEITSQRVLKMC----HNNALASTVPENSVVEEGTDDSAISGKATIKHFR 607

  Fly  1830 ---NLSEQRINTATDIEGVIIDIQQAKSSREPSPDRIVPTPVPAELETGKPRYPDVVQEPDDEPR 1891
               |.::...:|..|.  .:.......:.|..|....|.:||   |.||      :|.|
  Rat   608 TCGNANDSFSSTTADT--TLTSGNNCPNVRTISEVPSVGSPV---LTTG------LVNE------ 655

  Fly  1892 RKPQVTNIPIFEEESQTYVGCQISELHSSNGIEVDILDNP--TVEAPKSLDYPVNTPDTDESL-- 1952
                             :..|.::| |..||.::   .:|  :.:..||....:.:.|..:.:
  Rat   656 -----------------FAHCGLTE-HPGNGRQI---SSPFASKKKKKSQQRMITSKDKKKVIET 699

  Fly  1953 LSVHEKVSRFTHSAEKV-------------KEPKVSAPFSREFDVNAKIPENDDCLLSINQKVDK 2004
            ..:..||.:. |.|..:             ||.:|.   ..|.|.:..:.|:.|.....|.|..|
  Rat   700 KGIPNKVGKI-HRAGTIAQVVLLQDSGGLDKEGRVR---EEELDTSPMVIESHDIFPKGNSKFSK 760

  Fly  2005 -----FLRTAEN----------VIRPTSLPSRPEIERPGLEEIDEELLRDDCTLSVSQKVHKFID 2054
                 .|.|.:|          ..||..:.|..|:.:   :|..:|           .||  |:.
  Rat   761 NFHKNKLNTVQNPKTQKLLAKRKSRPLKIKSIGELRK---QETGQE-----------DKV--FLH 809

  Fly  2055 TAEKLAPTMPQKSPRLVANIERHISRQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEITQ 2119
            :..||..:..:|...|      |:....|.:::....|:               ||:||..|..:
  Rat   810 SESKLCESNLEKQSLL------HVFSSLEEDQKALHRSQ---------------SQVETVTENWK 853

  Fly  2120 TVTKKETLKEFKQQTKETRETRRD-----------------SKAEPEKLQKKSPQTKVKEESARV 2167
            .:|||..:.:........|..|:.                 ::|:|....||...|:      .:
  Rat   854 GMTKKSLVPKVNDLHVTVRNQRKQKGVKLKSGATVSEQHIATRADPLASLKKPDLTE------GI 912

  Fly  2168 PKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKDEPEKVNKR---EPKVPQKES 2229
            |.:..|  ..:.:|.....|.  |....:      |..||.:.:......|..   |..:|...|
  Rat   913 PHHSVK--SYIQRWLQNINPY--PDFEHR------KSAPLGQDRSNVVNYNSNGFPENNLPTTSS 967

  Fly  2230 QTK--LKEEPERVTKKTPQKEPRKEPLRQS---EDEPEFSPEE---EFDDEPL------------ 2274
            :.|  |.|..:|.||....|..:.:...:|   :|..| .|.:   |..||.|
  Rat   968 KGKSFLMESNKRKTKNANWKGNKNQETSKSLVVKDNGE-QPNKHSCESQDESLYDSYLGPLHDNC 1031

  Fly  2275 ---------PMTKTHTTA---------------IEMKRQK-DILNRPSVFGQRTP--------ER 2306
                     |.||:|.:.               ...|||. ::..:....|:..|        :.
  Rat  1032 TLSQTSINDPCTKSHLSTEKSRPEVKLVYQEMNFSTKRQTLEVAIQVDTMGENVPKDLLALLLQH 1096

  Fly  2307 KSSTTPSPTK-LNGTRGRP-------------SPSTNLITEEKRSYRNQVTNVSKPGTRKTTPSA 2357
            ..:..|:..| .||....|             :.||||:....     .|.|:.:        :.
  Rat  1097 LEAFIPNNQKHQNGISQLPGSLAEVVFPSAIYNSSTNLLLAWL-----LVLNLKR--------NM 1148

  Fly  2358 NSPAQSPPPKTTSISKR---MEQISQQSWVVQDVDVDVEVV------------GPAPPSHISEKP 2407
            ||..||..|||||.|..   :..:.:...:.::.| |::..            ||      |.:.
  Rat  1149 NSFCQSDAPKTTSRSSETAALLDVLKHVAITEEAD-DLKAAVANLVESTKTCSGP------SGRE 1206

  Fly  2408 QGKSPSPTSSRSLSRSPSRSPSRRTSTNL-------------------NTTSTNTTTTTEHPSTI 2453
            |..:|:...:.||........::.|..:|                   ..:.:|.|.:..|  |:
  Rat  1207 QDTAPANCIAASLHSVDKCKENKSTQKSLLDEGYSVRGDCGPELCVLEMVSKSNNTPSEGH--TV 1269

  Fly  2454 KTTTPKPTSTNPSKDEPEIIPIESLTEKSITTTYTTNTTG------------RNVASRRNVFEPV 2506
            ..|.| |...|...|  .:......:..|..:|:..:..|            :..|.:.|::|..
  Rat  1270 SMTYP-PKGVNNQND--ALFTSNDSSTMSQRSTHNASFLGEACLLTDSLCSHKACAQKDNIYEAA 1331

  Fly  2507 ---HETHV-------------------DSEPTGRRPSYMDHTKSSLEHIRRDSLEINKSHYSRKS 2549
               .|||:                   |:.........:|.....| :|..||::.|:|..|..|
  Rat  1332 CLSDETHIPIRDCKTIEFVNSKENKCTDNLELTEEIKTVDKVPKDL-NILADSIDKNESDISTSS 1395

  Fly  2550 -------------------SMEDDSPVE------PR---NPNSSVKFDVPRKSSSRGADEPRK-- 2584
                               |.:|.||:|      |:   |...||..|   |..||.::|||.
  Rat  1396 QNVNKLSSQGIFLSKTHLDSDKDYSPLEEFQNCPPKKIVNKKKSVSSD---KEDSRTSEEPRSIT 1457

  Fly  2585 TSLKGKDEDSDLELEIEEIFDLQRLEKLLETVASYEMRRRIRAQMRLIRKNMINAGTTTTITTIT 2649
            .|:...:.::..|||..|       |...:....:.|
  Rat  1458 NSVTSSERNATSELESFE-------ESESQDTGIFNM---------------------------- 1487

  Fly  2650 TSTTPGKSSPLPKIRRDQSPAGAAEVKTKEVRTTTSRRQQQQRVEQVDSTTPIAPGKTSPHGKPP 2714
                        |:|.::..|..:..|..|.|.:         :|.::
  Rat  1488 ------------KVRTEEKAAKESMQKESEARMS---------LELIN----------------- 1514

  Fly  2715 VKPRERSASPAQKRRISPPGKQSPGDRSTTTTTKVTTTSTTRGAPSKPAQGPIWADRSKVLKGHA 2779
                      ...|.|...|:::        |..:.||.                      :|..
  Rat  1515 ----------ISGRNIIEQGRRN--------TAFLETTG----------------------RGQV 1539

  Fly  2780 TVP------QTNGSTPRKGSTSSTTSSSGKITRTMTSSSTTTSSSSTTNTRNKQREEDSIT-SSY 2837
            |.|      .:|.:|.::.|...|.....||..:|.:.|.|.||   .|...:.|...::. |.|
  Rat  1540 TPPSLVFCYDSNKNTEKEMSVGETKMRVKKIVDSMENESYTDSS---LNCNKQHRSPGTLDWSDY 1601

  Fly  2838 GVGPTDENGLPLFGIRALKKKATPPAEEPCETKQEVTGYVIEEQFYSDNKSPPRHERKELIYSSN 2902
            |                                             ||::|  |:..|.|.|
  Rat  1602 G---------------------------------------------SDSES--RYPCKALSY--- 1616

  Fly  2903 ADELAAIKQQLQDEDDSSPPLLDARVVREFKKVESQQSLPEDARYVRRGSVKELSEKFIRKESSS 2967
                       :..||:...       ||:.                ||.|:...||...|....
  Rat  1617 -----------EHSDDTGQE-------REYP----------------RGIVRRAIEKLYGKAEII 1647

  Fly  2968 STHSTHSSIAQSLVRHEDETEDDSESNDVC--SVIEAPQMRQNQSHTMSTTRSSNTRSFLNSSAD 3030
            .....|.||.:|               .||  :.:|.|.:::...:      .|..:|.::|...
  Rat  1648 KPPFFHGSIHKS---------------QVCPYNPVEVPCVKKTHFY------ESECQSLVSSEQV 1691

  Fly  3031 QRQVTSVDDVLERMRNADNVEEPGDSSEDREARALLNKFLGASVIMQGVESMLPPTATGQ----- 3090
            .|....:.:..|..::..:....|||..|                 ..:|.:..|:..|:
  Rat  1692 SRSSLMLQEFQEERQSEVDANGMGDSFGD-----------------SSIEKVTKPSEHGRVFMEK 1739

  Fly  3091 ---RLNSQGVKTTRITNTYSKSGNSTSTTNNTSNTTNKVSSSSAPVTRTTCDIEEIWDEQVLKQL 3152
               :|...|....|..:.:..|.::.....|...|:                ::.:.|
  Rat  1740 EKGKLIDNGKWLLRENHLWRVSLDNPGMYGNADTTS----------------VDTLMD------- 1781

  Fly  3153 LEQASTYEERRKIRARLRELMAEREEQKNLKQAPKEEKEE-------EESSASEYEEI---IEEV 3207
                                       ||..:.|.....|       .|.|:||.||:   :|..
  Rat  1782 ---------------------------KNSIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVK 1819

  Fly  3208 TDY------SDEEEEVPPKKEEPKKEEVTKKEVT---KKEVTTKQQEEIQQKAVKKVEKTETKTS 3263
            .:|      ||         .||..|:....:.|   |:::....:||   |.....|:|.|..:
  Rat  1820 CNYFNFPHGSD---------SEPFGEDFLDAQNTNCPKEKIPNHHKEE---KRNSPSERTCTPVT 1872

  Fly  3264 QATESVSKKLAKV-----ELASSSSSSTTDGVQVQGESLPAKATKTG-----ATGAAGPVSSSSI 3318
            |...|...|:..|     :......||.|.|...:|:||.......|     .|....||:....
  Rat  1873 QTFASAGNKVHPVCSDVIKTQPLPGSSITHGALQEGDSLDKLYALCGQHCPILTVIIQPVNEEDR 1937

  Fly  3319 G--SRKSSSLSSS 3329
            |  .||.|.:.:|
  Rat  1938 GFAYRKDSDIENS 1950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290	6/41 (15%)
		Smoothelin	3127..3176	CDD:289290	1/48 (2%)
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
Rp1	XP_008761780.1	DCX	60..135	CDD:176357	16/87 (18%)
Rp1	XP_008761780.1	DCX	182..257	CDD:176357	14/90 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900