Protein Alignment CG34417 and SMTN

DIOPT Version :10

• Sequence 1: NP_001259282.1
• Gene: CG34417 / 31591
• FlyBaseID: FBgn0085446
• Length: 5182
• Species: Drosophila melanogaster
• Sequence 2: NP_001369571.1
• Gene: SMTN / 6525
• HGNCID: 11126
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 1343
• Identity: 286/1343 - (21%)
• Similarity: 431/1343 - (32%)
• Gaps: 500/1343 - (37%)

  Fly  3858 QLQREQLQREQLQREQLQREQLQREQLQRDQLQLQQQQQAAAAVQIERQRRQELERQLRLEQEAR 3922
            :|||::|:||:   |.|..::.:.|:....:..|..||:       |.::|..|.| |..:.|:.
Human   130 ELQRQELEREE---EALASKRFRAERQDNKENWLHSQQR-------EAEQRAALAR-LAGQLESM 183

  Fly  3923 FEREERTRLER---EYYEQQLQRQQVERQQQLDRQRQQQEQMERQRRQEMELRLQQQREQAAQVN 3984
            .:.||.|.|.|   ||.|::|.|..:                .|.|.||:|         ||.:.
Human   184 NDVEELTALLRSAGEYEERKLIRAAI----------------RRVRAQEIE---------AATLA 223

  Fly  3985 NFIHAPQSVFRPIENETQPQPGIYKPIAHKSQPNPAVWKPPTQQSQPPQQSQQHLQPRSATTYSN 4049
            ..:::.    ||.....:...|:   .||:           .:|.:.|::.:|..|   |.....
Human   224 GRLYSG----RPNSGSREDSKGL---AAHR-----------LEQCEVPEREEQEQQ---AEVSKP 267

  Fly  4050 TPSPSSTA--TSPIGLPWVAKPKVDNSDFRRKAHHFEERSLRDNIEQQQQPTYPNGNNGYLQRHN 4112
            ||:|..|:  .:.:.|...|.|...:|                      .|..|:.
Human   268 TPTPEGTSQDVTTVTLLLRAPPGSTSS----------------------SPASPSS--------- 301

  Fly  4113 SLRSKAPALSEFKKRPSLPNAMD---PGTAAPPRQVYQAPPPPTNISFTYADFPPVRRPQGASAH 4174
               |..||..|....|:....:.   ||:..||      |.||...|         ..||
Human   302 ---SPTPASPEPPLEPAEAQCLTAEVPGSPEPP------PSPPKTTS---------PEPQ----- 343

  Fly  4175 NYRSQPCLTSAVDQV--EALTNPLGAPLVLTSSNPTYLPPPGSRRFDYISSPVDVDADSPPNSPT 4237
               ..|.|.|...||  :.|:.|...|   .:.:||..|....|        .||....|.....
Human   344 ---ESPTLPSTEGQVVNKLLSGPKETP---AAQSPTRGPSDTKR--------ADVAGPRPCQRSL 394

  Fly  4238 SFMTMPNPTLMTDNTDDDLDLDSDNNMLEYRAETKVMRKPRS-QTAVRVADRRNAHMSDDEVYGK 4301
            |.::...|.                   :.|..|.:...|.| |.|..|.||.:...||
Human   395 SVLSPRQPA-------------------QNRESTPLASGPSSFQRAGSVRDRVHKFTSD------ 434

  Fly  4302 NSRAAKSLLYTMKQLGGGPGNASVGNSGQRRQPLTAPSSPKSGCLSPDGRPYQAPLVEPLFPQLS 4366
                                                  ||.:..|. ||
Human   435 --------------------------------------SPMAARLQ-DG---------------- 444

  Fly  4367 TFEPKRQPQFANSPMSTPPAVSMPSINYQANPTYTPPRSNQNSNSYLGETNTSYVVTYPLDDSGD 4431
                  .||.|.||: ||..:..||:      |.|.|.|:.:.:|..|.::||         |..
Human   445 ------TPQAALSPL-TPARLLGPSL------TSTTPASSSSGSSSRGPSDTS---------SRF 487

  Fly  4432 EPEPESMATSVSQRLRRTSEHSNASSSLSLGSTSWTANPVHNTVPSVPLDSAMGPPVDRSTKPQV 4496
            ..|...:|..::|                |.|......|....:.:.||::..|.||.||.:|
Human   488 SKEQRGVAQPLAQ----------------LRSCPQEEGPRGRGLAARPLENRAGGPVARSEEP-- 534

  Fly  4497 SQPVGPKMPQHVAQKQIPQQLPNQLPQQIPQQLPKQLPQQIPQQLPQQLPQQLPKQLPQQIPPQL 4561
                |..:|..|...:....:......:|.....:....::
Human   535 ----GAPLPVAVGTAEPGGSMKTTFTIEIKDGRGQASTGRV------------------------ 571

  Fly  4562 PKQLPQQIPQPELPQQLPNNLPRHAPKLSSRSHTIQGDSGYENRPLQNRVMSQQTLNSSIITSNN 4626
              .||....:.||...|     |..|.|.|.|      ||.:               |:|...|:
Human   572 --LLPTGNQRAELTLGL-----RAPPTLLSTS------SGGK---------------STITRVNS 608

  Fly  4627 HTTVQKQQKEQHINELRRKSLGNVLESSQRSTYFEQEYKSSAPPDTPDIVKSSLPKEDA-PLLKK 4690
            ..|:.:.....|:...                       |.|||.:.......:..|.| ||...
Human   609 PGTLARLGSVTHVTSF-----------------------SHAPPSSRGGCSIKMEAEPAEPLAAA 650

  Fly  4691 FGPPQRHHYMPNSYQSPQLNK--QGNSNSTTTSSTSVRSTTVVQQQHHQ----QQHQQIKPSIVE 4749
            .       ...|..:..::||  :|.|..:.....::....|:.:...|    ::.:.|:.::.|
Human   651 V-------EAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGVLDKMLDQSTDFEERKLIRAALRE 708

  Fly  4750 TPATPQPQVPPEDEIPHNIVFNNVSAFTSMSRRNHEEDSHQGTQSGSRVNRLSKCDSWNQICQLQ 4814
            .                            ..|:..:.|.       .|..||.:.
Human   709 L----------------------------RQRKRDQRDK-------ERERRLQEA---------- 728

  Fly  4815 QTAGPSPAKYNQPGSPGELR-----RTKSGHSLAVPKLYEAGIDKAQVSEKQRTVAAYFSGQKSP 4874
                        .|.|||.|     .|.:.||       :...|.:.||...:|.....|.
Human   729 ------------RGRPGEGRGNTATETTTRHS-------QRAADGSAVSTVTKTERLVHSN---- 770

  Fly  4875 TGGQVEELRTSMTTTTSSRKSAINRTKTSEKLSAAARKSLSSLTTTSNGNVSTAGLGMVVRGGGV 4939
                 :..||:.|||..|  |.:.|::.....:....|:.||.:::..
Human   771 -----DGTRTARTTTVES--SFVRRSENGSGSTMMQTKTFSSSSSSKK----------------- 811

  Fly  4940 GGIGGGAALSR-SATMPHIANLNLLDESNVEDAFEQLMMAQHKSSSSSEQRTETKSKDGGATVTT 5003
                .|:...| ....|...:|..|::...|.. ::||.||....:|:.|..:
Human   812 ----MGSIFDREDQASPRAGSLAALEKRQAEKK-KELMKAQSLPKTSASQARK------------ 859

  Fly  5004 TTTKVTTRTVSGSAASKNISPLAKFKQLDKQAAAQQAQKSSPTTSTPTTPGGSAQPLFKFTDPAL 5068
                                  |..::|:|:.||          .:|..|..:.|....|..|..
Human   860 ----------------------AMIEKLEKEGAA----------GSPGGPRAAVQRSTSFGVPNA 892

  Fly  5069 NARAATVKDQLLQWCKHKTQEYENVQINNFSSSWSDGLAFCALIHHFLPDAFDYTTLTKQTRRHN 5133
            |    ::|..||.||:.||:.||:|.|.|||||||||:|||||:|:|.|:||||..|:.|.||.|
Human   893 N----SIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQN 953

  Fly  5134 FELAFSVADEKAGIAPLLDVEDMVEMSRPDWKCVFVYVQSIYR 5176
            ||:|||.|:..|....|||.||||.:..||||||:.|:|..||
Human   954 FEVAFSSAETHADCPQLLDTEDMVRLREPDWKCVYTYIQEFYR 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	PHA03247	<566..1191	CDD:223021
		PTZ00449	<1035..1421	CDD:185628
		PTZ00449	<1394..1702	CDD:185628
		PTZ00121	<2080..2248	CDD:173412
		Smoothelin	2594..2636	CDD:463614
		Smoothelin	3127..3176	CDD:463614
		Smc	<3810..>3916	CDD:440809	16/57 (28%)
		PHA03247	<4126..4601	CDD:223021	90/480 (19%)
		CH_SMTN-like	5074..5179	CDD:409049	61/103 (59%)
SMTN	NP_001369571.1	Smoothelin	86..128	CDD:463614
		Smoothelin	167..216	CDD:463614	17/65 (26%)
		Smoothelin	664..713	CDD:463614	7/76 (9%)
		CH_SMTNB	894..1005	CDD:409108	61/103 (59%)