DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34417 and SMTN

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001369571.1	Gene:	SMTN / 6525	HGNCID:	11126	Length:	1009	Species:	Homo sapiens

Alignment Length:	1343	Identity:	286/1343 - (21%)
Similarity:	431/1343 - (32%)	Gaps:	500/1343 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  3858 QLQREQLQREQLQREQLQREQLQREQLQRDQLQLQQQQQAAAAVQIERQRRQELERQLRLEQEAR 3922
            :|||::|:||:   |.|..::.:.|:....:..|..||:       |.::|..|.| |..:.|:.
Human   130 ELQRQELEREE---EALASKRFRAERQDNKENWLHSQQR-------EAEQRAALAR-LAGQLESM 183

  Fly  3923 FEREERTRLER---EYYEQQLQRQQVERQQQLDRQRQQQEQMERQRRQEMELRLQQQREQAAQVN 3984
            .:.||.|.|.|   ||.|::|.|..:                .|.|.||:|         ||.:.
Human   184 NDVEELTALLRSAGEYEERKLIRAAI----------------RRVRAQEIE---------AATLA 223

  Fly  3985 NFIHAPQSVFRPIENETQPQPGIYKPIAHKSQPNPAVWKPPTQQSQPPQQSQQHLQPRSATTYSN 4049
            ..:::.    ||.....:...|:   .||:           .:|.:.|::.:|..|   |.....
Human   224 GRLYSG----RPNSGSREDSKGL---AAHR-----------LEQCEVPEREEQEQQ---AEVSKP 267

  Fly  4050 TPSPSSTA--TSPIGLPWVAKPKVDNSDFRRKAHHFEERSLRDNIEQQQQPTYPNGNNGYLQRHN 4112
            ||:|..|:  .:.:.|...|.|...:|                      .|..|:.
Human   268 TPTPEGTSQDVTTVTLLLRAPPGSTSS----------------------SPASPSS--------- 301

  Fly  4113 SLRSKAPALSEFKKRPSLPNAMD---PGTAAPPRQVYQAPPPPTNISFTYADFPPVRRPQGASAH 4174
               |..||..|....|:....:.   ||:..||      |.||...|         ..||
Human   302 ---SPTPASPEPPLEPAEAQCLTAEVPGSPEPP------PSPPKTTS---------PEPQ----- 343

  Fly  4175 NYRSQPCLTSAVDQV--EALTNPLGAPLVLTSSNPTYLPPPGSRRFDYISSPVDVDADSPPNSPT 4237
               ..|.|.|...||  :.|:.|...|   .:.:||..|....|        .||....|.....
Human   344 ---ESPTLPSTEGQVVNKLLSGPKETP---AAQSPTRGPSDTKR--------ADVAGPRPCQRSL 394

  Fly  4238 SFMTMPNPTLMTDNTDDDLDLDSDNNMLEYRAETKVMRKPRS-QTAVRVADRRNAHMSDDEVYGK 4301
            |.::...|.                   :.|..|.:...|.| |.|..|.||.:...||
Human   395 SVLSPRQPA-------------------QNRESTPLASGPSSFQRAGSVRDRVHKFTSD------ 434

  Fly  4302 NSRAAKSLLYTMKQLGGGPGNASVGNSGQRRQPLTAPSSPKSGCLSPDGRPYQAPLVEPLFPQLS 4366
                                                  ||.:..|. ||
Human   435 --------------------------------------SPMAARLQ-DG---------------- 444

  Fly  4367 TFEPKRQPQFANSPMSTPPAVSMPSINYQANPTYTPPRSNQNSNSYLGETNTSYVVTYPLDDSGD 4431
                  .||.|.||: ||..:..||:      |.|.|.|:.:.:|..|.::||         |..
Human   445 ------TPQAALSPL-TPARLLGPSL------TSTTPASSSSGSSSRGPSDTS---------SRF 487

  Fly  4432 EPEPESMATSVSQRLRRTSEHSNASSSLSLGSTSWTANPVHNTVPSVPLDSAMGPPVDRSTKPQV 4496
            ..|...:|..::|                |.|......|....:.:.||::..|.||.||.:|
Human   488 SKEQRGVAQPLAQ----------------LRSCPQEEGPRGRGLAARPLENRAGGPVARSEEP-- 534

  Fly  4497 SQPVGPKMPQHVAQKQIPQQLPNQLPQQIPQQLPKQLPQQIPQQLPQQLPQQLPKQLPQQIPPQL 4561
                |..:|..|...:....:......:|.....:....::
Human   535 ----GAPLPVAVGTAEPGGSMKTTFTIEIKDGRGQASTGRV------------------------ 571

  Fly  4562 PKQLPQQIPQPELPQQLPNNLPRHAPKLSSRSHTIQGDSGYENRPLQNRVMSQQTLNSSIITSNN 4626
              .||....:.||...|     |..|.|.|.|      ||.:               |:|...|:
Human   572 --LLPTGNQRAELTLGL-----RAPPTLLSTS------SGGK---------------STITRVNS 608

  Fly  4627 HTTVQKQQKEQHINELRRKSLGNVLESSQRSTYFEQEYKSSAPPDTPDIVKSSLPKEDA-PLLKK 4690
            ..|:.:.....|:...                       |.|||.:.......:..|.| ||...
Human   609 PGTLARLGSVTHVTSF-----------------------SHAPPSSRGGCSIKMEAEPAEPLAAA 650

  Fly  4691 FGPPQRHHYMPNSYQSPQLNK--QGNSNSTTTSSTSVRSTTVVQQQHHQ----QQHQQIKPSIVE 4749
            .       ...|..:..::||  :|.|..:.....::....|:.:...|    ::.:.|:.::.|
Human   651 V-------EAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGVLDKMLDQSTDFEERKLIRAALRE 708

  Fly  4750 TPATPQPQVPPEDEIPHNIVFNNVSAFTSMSRRNHEEDSHQGTQSGSRVNRLSKCDSWNQICQLQ 4814
            .                            ..|:..:.|.       .|..||.:.
Human   709 L----------------------------RQRKRDQRDK-------ERERRLQEA---------- 728

  Fly  4815 QTAGPSPAKYNQPGSPGELR-----RTKSGHSLAVPKLYEAGIDKAQVSEKQRTVAAYFSGQKSP 4874
                        .|.|||.|     .|.:.||       :...|.:.||...:|.....|.
Human   729 ------------RGRPGEGRGNTATETTTRHS-------QRAADGSAVSTVTKTERLVHSN---- 770

  Fly  4875 TGGQVEELRTSMTTTTSSRKSAINRTKTSEKLSAAARKSLSSLTTTSNGNVSTAGLGMVVRGGGV 4939
                 :..||:.|||..|  |.:.|::.....:....|:.||.:::..
Human   771 -----DGTRTARTTTVES--SFVRRSENGSGSTMMQTKTFSSSSSSKK----------------- 811

  Fly  4940 GGIGGGAALSR-SATMPHIANLNLLDESNVEDAFEQLMMAQHKSSSSSEQRTETKSKDGGATVTT 5003
                .|:...| ....|...:|..|::...|.. ::||.||....:|:.|..:
Human   812 ----MGSIFDREDQASPRAGSLAALEKRQAEKK-KELMKAQSLPKTSASQARK------------ 859

  Fly  5004 TTTKVTTRTVSGSAASKNISPLAKFKQLDKQAAAQQAQKSSPTTSTPTTPGGSAQPLFKFTDPAL 5068
                                  |..::|:|:.||          .:|..|..:.|....|..|..
Human   860 ----------------------AMIEKLEKEGAA----------GSPGGPRAAVQRSTSFGVPNA 892

  Fly  5069 NARAATVKDQLLQWCKHKTQEYENVQINNFSSSWSDGLAFCALIHHFLPDAFDYTTLTKQTRRHN 5133
            |    ::|..||.||:.||:.||:|.|.|||||||||:|||||:|:|.|:||||..|:.|.||.|
Human   893 N----SIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQN 953

  Fly  5134 FELAFSVADEKAGIAPLLDVEDMVEMSRPDWKCVFVYVQSIYR 5176
            ||:|||.|:..|....|||.||||.:..||||||:.|:|..||
Human   954 FEVAFSSAETHADCPQLLDTEDMVRLREPDWKCVYTYIQEFYR 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769	8/23 (35%)
		coiled coil	3857..3868	CDD:293879	5/9 (56%)
		CH	5076..5179	CDD:237981	61/101 (60%)
SMTN	NP_001369571.1	Smoothelin	86..128	CDD:403640
		Smoothelin	167..216	CDD:403640	17/65 (26%)
		Smoothelin	664..713	CDD:403640	7/76 (9%)
		CH_SMTNB	894..1005	CDD:409108	61/103 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4923
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001328
OrthoInspector	1	1.000	-	-		otm41222
orthoMCL	1	0.900	-	-		OOG6_107654
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740