DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and specc1la

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001034905.1	Gene:	specc1la / 561775	ZFINID:	ZDB-GENE-060810-139	Length:	1132	Species:	Danio rerio

Alignment Length:	874	Identity:	204/874 - (23%)
Similarity:	336/874 - (38%)	Gaps:	189/874 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  4429 SGDEPEPESMATSVSQRLRRTSEHSNASSSLSLGSTSWTANPVHNTVPSVPLDSAMGPPVDRSTK 4493
            ||.....:|.::.|.|.:..:.:..:|.|.....|:|               :|..|||..||:.
Zfish   322 SGSTDNLDSESSEVYQAVTSSDDALDAPSGCGSSSSS---------------ESEGGPPACRSSS 371

  Fly  4494 PQVSQPVGPKMPQHVAQKQIPQQLPNQLPQQIPQQLPKQLPQQIP--QQLPQQLPQQLPKQLPQQ 4556
            .:.|.....::......::|.|...||  ....::|...| |::.  ||:.|:|..:..:...::
Zfish   372 RKGSSGNTSEVSVACLTERIHQMEENQ--HSTSEELQATL-QELADLQQITQELNGENERLGEEK 433

  Fly  4557 IPPQLPKQLPQQIPQPE-LPQQLP---NNLPRHA--------------PKLSSRSHTIQGDSGYE 4603
            :  .|...|.||..:.| ..:|:.   :.|..|.              .:|..|...:..::.:|
Zfish   434 V--LLMDSLCQQSDKLEHCGRQIEYFRSLLDEHGVAYSVDEDIKSGRYMELEQRYVELAENARFE 496

  Fly  4604 NRPLQNRVMSQQTLNSSIITSNNHTTVQK-----QQKEQHINEL------RRKSLGNVLES---- 4653
            ...|..  :.|...|:..:...::...|.     :::..|:..|      .|.|:..|||.
Zfish   497 REQLLG--VQQHLSNTLKMAEQDNAEAQNVIAALKERNHHMERLLDVERQERASMAAVLEECKAA 559

  Fly  4654 --------SQRSTYFEQE-------YKSSAPPDTPDIVK----SSLPKEDAPL-LKKFGPPQRHH 4698
                    |:.....|||       |......|..||.:    ..|.||:|.. ..|......|.
Zfish   560 VNNDQAELSRCRVLLEQERQKVAELYSIHNAGDKSDIHQLLEGVRLDKEEAEAKASKLQDDLGHA 624

  Fly  4699 YMPNSYQSPQLNK----QGNSNSTTTSSTSVRSTTVVQQQHHQQQHQ----QIKPSIVETPATPQ 4755
            ....:.....|||    ..:..|......:.:...:.:|:...|:.:    .:|.:|.|.
Zfish   625 RSEVACLQDTLNKLDAEYRDFQSVVQKELAEQKRAIEKQREDLQEKETEIGDMKETIFEL----- 684

  Fly  4756 PQVPPEDEIPH--------NIVFNNVSAFTSMSRRNHEEDSHQGTQSGSRVNRLSKCDS--WNQI 4810
                 |||:..        |::.:::    ..|.:..::..|...:....::|..:.:|  |.|.
Zfish   685 -----EDEVEQHRAVKLHDNLIISDL----ENSMKKLQDQKHDMEREIKILHRRLREESAEWRQF 740

  Fly  4811 CQLQQTAG--PSPAKYNQPGSPGELRR---------TKSGHSLAVPKLYEAGIDKAQV----SEK 4860
            ....|||.  .:..|.......|:|||         .|.|..:...|..:...::.:|    :..
Zfish   741 QADLQTAVVIANDIKSEAQEEIGDLRRRLQEAQEKNEKLGKEIEEVKNRKQDEERGRVYNYMNAV 805

  Fly  4861 QRTVAAYFSG-----------QKSPTGGQVEELRTSMTTTTSSRKSAINRTKTSEKLSAAARKSL 4914
            :|.:||...|           :.|||   |:.|..|.  .::|:....|.|..:...:|||..:.
Zfish   806 ERDLAALRQGMGLSRRPSTSSEPSPT---VKTLIKSF--DSASQGPGANATAVAAAAAAAAAAAA 865

  Fly  4915 SSLTTT-----------SNGNVST---AGLGMVVRGGGVGGIGGGAALSRSATMPHIANLNLLDE 4965
            .::|:|           |...:.|   |.:..:.|....|.:.....||           :|.|:
Zfish   866 VTVTSTTPTAPLPRTPLSPSPMKTPPAAAVSPIQRHSITGSMAAAKPLS-----------SLADK 919

  Fly  4966 ----SNVEDAFEQLMMAQHKSSSSSEQRTETKSKDGGATVTTTTTKVTTRTVS---GSAASKNIS 5023
                :::....|.|:.|.:...:|:.||..........||:..:::...|.:|   |..||..||
Zfish   920 RPSYTDISMPAEHLLRAANSRPASALQRVSNMDTSKTITVSRRSSEEPKRDISTPDGGPASSLIS 984

  Fly  5024 PLAKFKQLDKQAAAQQAQKSSPTTSTPTTPGGSAQPLFKFTDPALNARA----ATVKDQLLQWCK 5084
                     ..:||..:..||||.|...|.....:...|  || |:|.|    .:.::.||:||:
Zfish   985 ---------MSSAAALSSSSSPTASVNPTARSRLREERK--DP-LSALAREYGGSKRNALLRWCQ 1037

  Fly  5085 HKTQEYENVQINNFSSSWSDGLAFCALIHHFLPDAFDYTTLTKQTRRHNFELAFSVADEKAGIAP 5149
            .||:.|:|:.|.||||||:|||||||::|.:||....|..|..|.:|.||.|||..| |..||..
Zfish  1038 KKTEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELNSQDKRRNFTLAFQAA-ESVGIKS 1101

  Fly  5150 LLDVEDMVEMSRPDWKCVFVYVQSIYRRF 5178
            .||:.|||...||||:.|..||.|||:.|
Zfish  1102 TLDINDMVHTERPDWQSVMTYVTSIYKYF 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981	54/103 (52%)
specc1la	NP_001034905.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..381		16/73 (22%)
		DUF4515	595..791	CDD:291649	38/209 (18%)
		SPEC	608..793	CDD:295325	34/198 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..1016		21/87 (24%)
		CH	1030..1130	CDD:237981	53/100 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910