DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and Smtnl1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001178668.1	Gene:	Smtnl1 / 311167	RGDID:	1311701	Length:	470	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	138/508 - (27%)
Similarity:	206/508 - (40%)	Gaps:	98/508 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  4712 QGN--SNSTTTSSTSVRSTTVVQQQHHQQQHQQIKPSIVE-TPATPQPQVPPEDEIPHNIVFNNV 4773
            :||  .:.||.|.|:....|...|...::..:.....:.| |..|...:.|| |...|
  Rat     5 EGNPSEDGTTVSPTAGNLATPGSQGTAEEVAEGTAEEVAEGTVGTNDKEEPP-DGAEH------- 61

  Fly  4774 SAFTSMSRRNHEEDSHQGTQSGSRVNRLSKCDSWNQICQLQQTAGPSPAKYNQPGSPGELRRTKS 4838
                 :.:...|.....|.|..:.:....|.||..      :..|...||.:.....|....|..
  Rat    62 -----LCKAASEGGISGGCQVEASILEELKTDSQG------EARGKEEAKADLAEEKGGKEDTTV 115

  Fly  4839 GHSLAVPKLYEAGIDKAQVSEKQRTVAAYFSGQKSPTGGQVEELRTSMTTTTSSRKSAIN-RTKT 4902
            .......|..|...:.::|:||:..|.. ...||      |:|..|::   .|..||.:| :.:.
  Rat   116 SSQEDTGKKEETKPEPSEVTEKEEAVLP-LEKQK------VDEKETNL---ESKEKSDVNDKAEP 170

  Fly  4903 SEKLSAAARKSLSSLTTTSNGNVSTAGLGMVVRGGGVGGIGGGAALSRSATMPHIANLNLLDESN 4967
            ..|..|.|..::....|.|......                      :....|   .|..:|...
  Rat   171 ESKEDAGAEVTVKEAETESQKKADV----------------------KDQAEP---QLQEVDGKE 210

  Fly  4968 VEDAFEQLMMAQHKSSSSSEQRTETKSKDGGATVTTT--------TTKVTT---------RTVSG 5015
            .....::|:.....:....||..|.:|::..|.:.::        |.:.|:         .|.||
  Rat   211 ARSDTKELVEPGSPTEEQEEQGKENESEERAAVIPSSPEDWPESPTDEGTSLSPDGLGPESTASG 275

  Fly  5016 --SAASKNISPLAKFKQLDKQAAAQQAQKSSP--TTSTPTTP---------------GGSAQ--- 5058
              ||::...||....:...:...:::.::.:|  ..|.||.|               ||:|.
  Rat   276 ETSASASESSPSEVPESPTEPLPSEKKKERAPERRVSAPTRPRGPRAQNRKAIMDKFGGAASGPT 340

  Fly  5059 PLFKFTDPALNARAATVKDQLLQWCKHKTQEYENVQINNFSSSWSDGLAFCALIHHFLPDAFDYT 5123
            .||:.| .|..|....||:.||:||:..|:.||:|.|.|||||||.|:|||||||.|.||||||.
  Rat   341 ALFRNT-KAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYA 404

  Fly  5124 TLTKQTRRHNFELAFSVADEKAGIAPLLDVEDMVEMSRPDWKCVFVYVQSIYR 5176
            .|....|||||.||||.|::.|..|.||:|:|||.::.||.|||:.|:|.:||
  Rat   405 ELDPTKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYR 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981	60/101 (59%)
Smtnl1	NP_001178668.1	CH	357..457	CDD:237981	58/99 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4593
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001328
OrthoInspector	1	1.000	-	-		otm45358
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810