DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34417 and Smtn

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	XP_006514787.1	Gene:	Smtn / 29856	MGIID:	1354727	Length:	954	Species:	Mus musculus

Alignment Length:	1405	Identity:	315/1405 - (22%)
Similarity:	458/1405 - (32%)	Gaps:	557/1405 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  3845 QREKLQR--EQLQREQLQREQLQREQLQREQLQREQLQREQLQRDQLQLQQQQQAAAAVQIERQR 3907
            :|.:::.  .:|||::|:||:   |.|..::.:.|:...::......|.:.:||||.|
Mouse    26 ERRRIRSAIRELQRQELEREE---EALASKRFRAERQDNKENWLHSQQREAEQQAALA------- 80

  Fly  3908 RQELERQLRLEQEARFEREERTRLER---EYYEQQLQRQQVERQQQLDRQRQQQEQMERQRRQEM 3969
                  :|....|:..:.||.|.|.|   ||.|::|.|..:                .|.|.||:
Mouse    81 ------RLAGRLESMNDVEELTTLLRSAGEYEERKLIRAAI----------------RRVRAQEI 123

  Fly  3970 ELRLQQQREQAAQVNNFI--HAPQSVFRPIENETQPQPGIYKPIAHKSQPNPAVWKPPTQQSQPP 4032
                     :||.:...:  ..|.|         .|:....:..||...|.    |.|    :|.
Mouse   124 ---------KAATLAGRLCSRLPSS---------GPREDSRRQAAHTLDPG----KVP----EPE 162

  Fly  4033 QQSQQH--LQPRSATTYSNTPSPSSTATSPIGLPWVAKPKVDNSDFRRKAHHFEERSLRDNIEQQ 4095
            ||.||.  |:|        ||:|..|:                                     |
Mouse   163 QQEQQTEVLEP--------TPTPEDTS-------------------------------------Q 182

  Fly  4096 QQPTYPNGNNGYLQRHNSLRSKAPALSEFKKRPSLPNAMDPGTAAPPRQVYQAPPPPTNISFTYA 4160
            ...|.            :|..:||.    ..|||.|       |:|......|.|
Mouse   183 DVTTV------------TLLLRAPP----GGRPSSP-------ASPHNSPTSASP---------- 214

  Fly  4161 DFPPVRRPQGASAHNYRSQPCLTSAVDQVEALTNPLGAPLVLTSSNPTYLPPPGSRRFDYISSPV 4225
              .|:..|.||..      |.:.:.|.. |.|.:|..||    |..|...|.|.|.|...||.|
Mouse   215 --EPLLEPAGAQC------PAVEAPVSS-EPLPHPSEAP----SPEPPMSPVPSSSRGRVISKP- 265

  Fly  4226 DVDADSPPNSPTSFMTMPNPTLMTDNTDDDLDLDS----DNNMLEYRAETKVMRK------PRSQ 4280
                            :|.||..:|.      |||    .|......:|||..::      ||..
Mouse   266 ----------------LPGPTEPSDT------LDSIRGFSNTKRADPSETKSCQRSLSVLSPRQP 308

  Fly  4281 TAVRVADRRNAHMSDDEVYGKNSRAAKSLLYTMKQLGGGPGN-ASVGNSGQRRQPLTAPSSPKSG 4344
            |.                    :|...||        .||.. ..||:...|.|..|: .||...
Mouse   309 TP--------------------NREPTSL--------AGPSQFRRVGSVRDRVQKFTS-DSPVVA 344

  Fly  4345 CLSPDGRPYQAPLVEPLFPQLSTFEPKRQPQFANSPMSTPPAVSMPSINYQANPTYTPPRSNQNS 4409
            .|. ||.|..|         |::..|.|.|  ..|.:||.||.|                |:.||
Mouse   345 RLQ-DGPPRTA---------LASPTPTRLP--GPSLISTTPASS----------------SSSNS 381

  Fly  4410 NSYLGETNTSYVVTYPLDDSGDEPEPESMATSVSQRLRRTSEHSNASSSLSLGSTSWTANPVHNT 4474
            :|           ..|.|.|..:.:.| :|.|:::......|.......|:|.|
Mouse   382 SS-----------PSPSDTSSHKKQRE-LAHSLAELQSCPQEEGPGGRGLALRS----------- 423

  Fly  4475 VPSVPLDSAMGPPVDRSTKPQVSQP--VGPKMPQHVAQKQIPQQLPNQLPQQIPQQLPKQLPQQI 4537
                 |::..|.|...|.:|....|  ||...|....:.....::.:...|....::
Mouse   424 -----LENRAGGPKPCSEEPSTPPPVAVGTGEPGGSMKTTFTIEIKDGRGQASTGRV-------- 475

  Fly  4538 PQQLPQQLPQQLPKQLPQQIPPQLPKQLPQQIPQPELPQQLPNNLPRHAPKLSSRSHTIQGDSGY 4602
                                      .||....:.||...|     |..|.|.|.|      ||.
Mouse   476 --------------------------LLPTGNQRAELTLGL-----RAPPTLLSTS------SGG 503

  Fly  4603 ENRPLQNRVMSQQTLNSSIITSNNHTTVQKQQKEQHINELRRKSLGNVLESSQRSTYFEQEYKSS 4667
            :|               :|...:|..||.:.....|:......|.||      |...   .:|::
Mouse   504 KN---------------TITHISNPGTVTRLGSVTHVTTFSHASPGN------RGGC---NFKAA 544

  Fly  4668 APPDTPDIVKSSLPKEDAPLLKKFGPPQRHHYMPNSYQSPQLNKQGNSNSTTTSSTSVRSTTVVQ 4732
                           |||      |.|..|   |.::.:.:.:..|.|.
Mouse   545 ---------------EDA------GTPVAH---PPAFSTRRSSSGGPSR---------------- 569

  Fly  4733 QQHHQQQHQQIKPSIVETPATPQPQVPPEDEIPHNIVFNNVSAFTSMSRRNHEEDSHQGTQSGSR 4797
                       :.|::|    |.|..||.               |::...|..|.        :|
Mouse   570 -----------RSSLME----PDPAEPPS---------------TTVEAANGAEQ--------AR 596

  Fly  4798 VNRLSKCDSWNQICQLQQTAGPSPAKYNQPGSPGELRRTKSGHSLAVPKLYEAGIDKAQVSEKQR 4862
            |::                 ||   :...|.|..||...:....|      :..:|:....|:::
Mouse   597 VDK-----------------GP---EGRSPLSAEELTAIEDEGVL------DKMLDQTTNFEERK 635

  Fly  4863 TVAAYFSGQKSPTGGQVEE-----LRTSMTTTTSSRKSAINRTKTSEKLSAAARKSLSSLTTT-- 4920
            .:.|.....:.....|.::     ||.:......||.:....|.|.....||...::.::|.|
Mouse   636 LIRAALRELRQRKRDQRDKERERRLREARARPGESRSNVATETTTRHSQRAADGSTVGTVTKTER 700

  Fly  4921 ---SNGNVSTAGLGMVVRGGGVGGIGGGAALSRSATMPHIANLNLLDESNVEDAFEQLMMAQHKS 4982
               ||....||                     |:.|              ||.:|  :...::.|
Mouse   701 LVHSNDGTQTA---------------------RTTT--------------VESSF--MRRLENGS 728

  Fly  4983 SSSSEQRTETKSKDGGATVTTTTTKVTTRTVSGSAASKNISPLAKFKQLDKQAAA---------- 5037
            ||||                ||||.|.|::.|.|::|.:...:......:.|.::
Mouse   729 SSSS----------------TTTTTVQTKSFSSSSSSSSSKKMGSIFDREDQTSSRPGSLAALER 777

  Fly  5038 QQAQK--------SSPTTST-------------------PTTPGGSAQPLFKFTDPALNARAATV 5075
            :||:|        |.|.||.                   |.||..:.|....|..|..|    ::
Mouse   778 RQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGSAGGPGTPRTAVQRSTSFGVPNAN----SI 838

  Fly  5076 KDQLLQWCKHKTQEYENVQINNFSSSWSDGLAFCALIHHFLPDAFDYTTLTKQTRRHNFELAFSV 5140
            |..||.||:.||:.||:|.|.|||||||||:|||||:|:|.|:||||..|:.|.||.|||:|||.
Mouse   839 KQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEMAFSS 903

  Fly  5141 ADEKAGIAPLLDVEDMVEM-SRPDWKCVFVYVQSIYRRFR 5179
            |:......||::||||:.| .:||.||||.||||:|...|
Mouse   904 AEMLVDCVPLVEVEDMMIMGKKPDPKCVFTYVQSLYNHLR 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769	10/38 (26%)
		coiled coil	3857..3868	CDD:293879	3/10 (30%)
		CH	5076..5179	CDD:237981	61/103 (59%)
Smtn	XP_006514787.1	Smoothelin	1..34	CDD:372157	1/7 (14%)
		Smoothelin	73..122	CDD:372157	19/77 (25%)
		PHA03247	<107..454	CDD:223021	125/587 (21%)
		Smoothelin	601..648	CDD:372157	9/55 (16%)
		CH	839..943	CDD:237981	61/103 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4987
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001328
OrthoInspector	1	1.000	-	-		otm43286
orthoMCL	1	0.900	-	-		OOG6_107654
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.740