DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34417 and Micall2

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	XP_006249037.1	Gene:	Micall2 / 288515	RGDID:	1307875	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	1020	Identity:	222/1020 - (21%)
Similarity:	339/1020 - (33%)	Gaps:	313/1020 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 TSETVEEYDDRDQ-PTSRVVQKAPTPSYAPPSHSPRQSPAKDFSTHGFPSVRPNKATQEYPSQR- 528
            :|::.||...:.: |:......:|.|:...|     .|||:   |:  |.|:.|:...|.||.:
  Rat   122 SSDSTEELSGKKKVPSQPAKLSSPVPTQRLP-----LSPAR---TN--PVVQRNEGVSERPSPKA 176

  Fly   529 -PGIAGEEVVVVRSEKSRQV--------------------KQQTSSQRTIETEVVGDDYQEP--- 569
             ||..|..|..:.....:.|                    ||.:|:..:......|    ||
  Rat   177 APGTVGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATG----EPGVF 237

  Fly   570 --------------------QRSP-------------QKLRE---------APTPSWEQPATRRQ 592
                                .|.|             ||:.|         |.|.:||.....|
  Rat   238 VCTHHSSEAVSVSPKLSNLASRQPGGGIADTRPIGVSQKVLETNGEATPLRARTAAWEHAGGNR- 301

  Fly   593 PVEEDFSTHGFPSVRTT---TTSTRPDQPDGEVLHTSKTVSRNQSANRKTNTERIIETQVEHPNA 654
                  :..||.....|   |:......|.|..|..| ||: ..|||.|..|.....:.|...::
  Rat   302 ------AAKGFVQTELTPPATSRVHVGSPAGPRLPMS-TVT-TTSANSKATTHVTNSSPVGWSSS 358

  Fly   655 PSHSTPRSGSPRRSQPR--DDYASSPRGPA---GKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQ 714
            ...||..|||.....|.  ..:.|.|:|.|   |..:|.. |:|..|:|..|...:...:|.|..
  Rat   359 AQSSTGTSGSRPVVSPSALGAHLSVPQGQAASKGVKTQLN-SSTDSSSTAPTPAWTSSSSRTQQA 422

  Fly   715 KEREVDAAHRAFAASLRSSSPADSTTSVGSHHQTPRSSVSSNRTFRREMREGSHDSQAPSESSRI 779
            :|:        |..:| |.:||.:          |.||.|            ||.|:.|
  Rat   423 REK--------FFHNL-SPAPAPA----------PASSSS------------SHASRVP------ 450

  Fly   780 SSTTVTRHTTGGNVTSNTIKTKTTKPVKTASEPRSPTPKAGGSVTTTTTTITTKSSPSPAPASPT 844
              |.||  ...|.| |..:.|.|:| |.:|:....||.||...||            :|...:||
  Rat   451 --TVVT--APSGKV-SPLVNTSTSK-VPSATVVTVPTSKASTVVT------------APTSKAPT 497

  Fly   845 TAAPPTS-APASSAPPDNKLSQ-YTYTTTKPGDIFSLPPTTPPTINNEPTLTTTRNTTTTTTTTT 907
            ....|.| ||.....|.:|:|. .|..|:|...:.:.|.:...|:...|    |........|:.
  Rat   498 VVTVPISKAPTVVTAPTSKVSTVVTVPTSKASTVVTAPTSKASTVVTVP----TGRGHVVVNTSA 558

  Fly   908 TATSDNLQNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQYYQLGNEGENPETPES 972
            :..|..:.|..::|:.|.|...    :||.......|                |::..:..:|.:
  Rat   559 SKVSGVVDNPAQESSREQALSV----LRKALPGLTRA----------------GSQAPSRSSPAT 603

  Fly   973 SGT----PANKKPHQMRRPHDEPEPQLRRS-----SKSPSVEPRQVQRETTFEGRRVSQDREISI 1028
            |..    |.|:.|.::      |..:|..|     |.:|.:||.......:.....||
  Rat   604 SSVLITLPKNEVPPKV------PSAKLSHSTTQAFSPTPKMEPTAPLSVGSTSWTSVS------- 655

  Fly  1029 DELILIEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTP 1093
                 ::....:||.         |||...|.:.|    :|:|                 ||..|
  Rat   656 -----LQAGKKSPGI---------SPGIGKTSAVS----RPQA-----------------EVKGP 685

  Fly  1094 SQPEKQFPRARSPEKTPGWTQPQVSP-------RQSPEKQLPRA-QSPEKVPAVRQPSVSPRQSP 1150
            . |..|..:...||   || :.::.|       ::.|....||| .:|.|..:....|:....:|
  Rat   686 G-PTSQEGQEEGPE---GW-RARLKPVDKRALEQKEPVLAEPRAGDTPRKASSSSDSSIHITLTP 745

  Fly  1151 EKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVP------------------QKSRQSPEKDLTN 1197
            .:|...|...|.|..|...||   |.::....||                  .::|...||..|.
  Rat   746 IQQKRTPCLADSGSSLAAPSP---PSRRKKLVVPPTLDVSADWLQPELKKQDDQTRSCKEKTATW 807

  Fly  1198 QQRREEEIFRSTITTTQKRTTN--NLNEEFITNER-DNQNQPISEKKPQIP---ANAEPNTKPSE 1256
            ..|....|..:.:.:..:..|:  .|:..:|:.|. ..|.|.|..:...:.   ...|...:.:|
  Rat   808 GTRESSAILDNDLVSPDEAVTSPVRLHPNYISQEELQRQLQDIERQLDALELRGVELEKRLRAAE 872

  Fly  1257 TIESPDGGFPSKTTEVEAQPEVKESPTYRKKGLTRRET-----FEDRCRQILGMEEDGDTQG--- 1313
            ...|.||........:           :.|:.|.|||:     .:|:|.:    |...|.||
  Rat   873 GDASEDGLMVDWFRLI-----------HEKQLLLRRESELMYKSKDQCLE----ERQLDLQGELR 922

  Fly  1314 TYTERP---------NNEQEDVNVSHTTIETIQVKIEDCPNDDED 1349
            ...|:|         ..|||.:|   ..:.|:..:.:...|.|||
  Rat   923 RLMEKPEGLKSPQDRKREQELLN---QYVNTVNDRSDIVDNLDED 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
Micall2	XP_006249037.1	CH	5..102	CDD:278723
		LIM_Mical_like_1	189..242	CDD:188828	7/56 (13%)
		PARM	328..>546	CDD:293666	75/275 (27%)
		DUF3585	839..975	CDD:288945	31/144 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000