DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34417 and SPECC1L

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001138940.4	Gene:	SPECC1L / 23384	HGNCID:	29022	Length:	1117	Species:	Homo sapiens

Alignment Length:	1317	Identity:	262/1317 - (19%)
Similarity:	436/1317 - (33%)	Gaps:	404/1317 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  4023 KPPTQQSQPPQQSQQHL--------------QPRSATTYSNTPSPSSTA------TSPIGLPWVA 4067
            ||.|..|....:|...|              :.:.:|..|..||.|:.|      .|.|.....:
Human    42 KPGTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTAS 106

  Fly  4068 KPKVDNSDFRRKAHHFEERSLRDNIEQQQQPTYPNGNNGYLQRHNSLRSKAPALSEFKKRPS--- 4129
            ..|...|...:::....|| ||:.....|....|:...|......:.||::...:|...|.|
Human   107 STKRSTSTGNKESSSTRER-LRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSK 170

  Fly  4130 -------------------------------LPNAM-------------DPGTAAPPRQVYQAPP 4150
                                           |.|.:             ..|.....::...| .
Human   171 SDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMA-H 234

  Fly  4151 PPTNISFTYADFPPVRRPQGASAHNYRSQPCLTSAVDQVEALTNPLGAPLV-----------LTS 4204
            .||::..|....    :.|..:.....:|  |.:....::...|.||..|.           ..|
Human   235 QPTDVESTLLQL----QEQNTAIREELNQ--LKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQS 293

  Fly  4205 SNPTYLPPPGSRRFDYISSPVDVDADSPPNSPTSFMTMPNPTLMT---DNTDDDLDLDSDNNMLE 4266
            .:|...|...|.....::|.|:   .|.|.|....::....|||.   .|:.|:||
Human   294 LSPEITPGNQSDGGGTLTSSVE---GSAPGSVEDLLSQDENTLMDHQHSNSMDNLD--------- 346

  Fly  4267 YRAETKVMRKPRSQTAVRVADRRNAHMSDDEVYGKNSRAAKSLLYTMKQLGGGPGNASVGNSGQR 4331
              :|...:.:|.:.             |||.:...:|..::.:....:...|..|||
Human   347 --SECSEVYQPLTS-------------SDDALDAPSSSESEGIPSIERSRKGSSGNA-------- 388

  Fly  4332 RQPLTAPSSPKSGCLS-----------PDGRPYQAPLVEPLFPQLSTFEPKRQPQFANSPMSTPP 4385
                   |.....||:           ......||.|.|....|..|.|...:    |..:....
Human   389 -------SEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSE----NERLGEEK 442

  Fly  4386 AVSMPSINYQANPTYTPPRSNQNSNSYLGETNTSYVVTYPLDDSGDEPEPESMATSVSQRLRRTS 4450
            .:.|.|:..|::......|..:...|.|.|.:.|||:        ||.........:.||....:
Human   443 VILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVI--------DEDVKSGRYMELEQRYMDLA 499

  Fly  4451 EHSNASSSLSLGSTSWTANPVHNTVPSVPLDS-----AMGPPVDRS--------TKPQVSQPVGP 4502
            |::.......||    ....:.||:.....|:     .:|...:||        ::.:....:..
Human   500 ENARFEREQLLG----VQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAA 560

  Fly  4503 KMPQH---VAQKQIPQQLPNQLPQQIPQQLPK-----------------------QLPQQIPQQL 4541
            .:.::   ||..||..   |:|..|:..:..|                       :|.::..:.|
Human   561 TLEEYKATVASDQIEM---NRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETL 622

  Fly  4542 PQQLPQQL------PKQLPQQIPP------QLPKQLPQQIPQPELP-QQLPNNLPRHAPKLSSRS 4593
            ...|.:.|      ..:|...|..      ...::..:||....:. ::|.::|.....:.|...
Human   623 ASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMK 687

  Fly  4594 HTIQGDSGYENRPLQNRVMSQQTLNSSIITSNNHTTVQKQQKEQHINELRRKSLGNVL-ESSQRS 4657
            .||   ...|:...|:|.:.   |:.::|.|:...||:|.|.::|..|...|:|...| |.|...
Human   688 ETI---FELEDEVEQHRAVK---LHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEW 746

  Fly  4658 TYFEQEYKSSAPPDTPDIVKSSLPKEDAPLLKKFGPPQRHHYMPNSYQSPQLNKQGNSNSTTTSS 4722
            ..|:.:.:::..  ..:.:||...:|...|.::.
Human   747 RQFQADLQTAVV--IANDIKSEAQEEIGDLKRRL------------------------------- 778

  Fly  4723 TSVRSTTVVQQQHHQQQHQQIKPSIVETPATPQPQVPPEDEIPHNIVFNNVSAF----------T 4777
                       ...|::::::...:.|..:..|     |:|  ...|:|.::|.          .
Human   779 -----------HEAQEKNEKLTKELEEIKSRKQ-----EEE--RGRVYNYMNAVERDLAALRQGM 825

  Fly  4778 SMSRRNHEEDSHQGTQSGSRVNRLSKC-DSWNQICQLQQTAGPSPAKYNQPGSPGELRRTKSGHS 4841
            .:|||     |...::....|..|.|. ||.:|:        |:||....|.:|......|:..:
Human   826 GLSRR-----SSTSSEPTPTVKTLIKSFDSASQV--------PNPAAAAIPRTPLSPSPMKTPPA 877

  Fly  4842 LAVPKLYEAGIDKAQVSEKQRTVAAYFSGQKSPTGGQVEELRTSMTTTTSSRKSAINRTKTSEKL 4906
            .||..:....|.....:.|..|..:    .|.|..|::......:.|:::||.:::.|....|
Human   878 AAVSPMQRHSISGPISTSKPLTALS----DKRPNYGEIPVQEHLLRTSSASRPASLPRVPAME-- 936

  Fly  4907 SAAARKSLSSLTTTSNGNVSTAGLGMVVRGGGVGGIGGGAALSRSATMPHIANLNLLDESNVEDA 4971
               :.|:||                                :||
Human   937 ---SAKTLS--------------------------------VSR--------------------- 945

  Fly  4972 FEQLMMAQHKSSSSSEQRTETKSKDGGATVTTTTTKVTTRTVSGSAASKNISPLAKFKQLDKQAA 5036
                       .||.|.:.:..:::|.:..:......|             ||
Human   946 -----------RSSEEVKRDISAQEGASPASLMAMGTT-------------SP------------ 974

  Fly  5037 AQQAQKSSPTTS-TPTTPGGSAQPLFKFTDPALNARA----ATVKDQLLQWCKHKTQEYENVQIN 5096
             |.:..||||.| ||||.....:   :..|| |:|.|    .:.::.||:||:.||:.|:|:.|.
Human   975 -QLSLSSSPTASVTPTTRSRIRE---ERKDP-LSALAREYGGSKRNALLKWCQKKTEGYQNIDIT 1034

  Fly  5097 NFSSSWSDGLAFCALIHHFLPDAFDYTTLTKQTRRHNFELAFSVADEKAGIAPLLDVEDMVEMSR 5161
            ||||||:||||||||:|.:||....|..|..|.:|.||.|||..| |..||...||:.:||...|
Human  1035 NFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAA-ESVGIKSTLDINEMVRTER 1098

  Fly  5162 PDWKCVFVYVQSIYRRF 5178
            |||:.|.:||.:||:.|
Human  1099 PDWQNVMLYVTAIYKYF 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981	53/103 (51%)
SPECC1L	NP_001138940.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..176		28/134 (21%)
		DUF3584	<176..>803	CDD:403375	121/749 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..323		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..390		8/59 (14%)
		Smc	<500..801	CDD:224117	55/362 (15%)
		PHA03247	<827..992	CDD:223021	51/276 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..997		27/174 (16%)
		CH_CYTS	1005..1116	CDD:409048	54/112 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910