DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and SMTNL1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001099035.2	Gene:	SMTNL1 / 219537	HGNCID:	32394	Length:	494	Species:	Homo sapiens

Alignment Length:	502	Identity:	134/502 - (26%)
Similarity:	197/502 - (39%)	Gaps:	132/502 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  4746 SIVETPAT---PQPQVPPEDEIPHNIVFNNVSAFTSMSRRNHEEDSHQGTQSGSRVNRLSKCDSW 4807
            :|.|.|.|   .|.:.|.||.:...:                     ||..:|     |.:....
Human    41 AINEGPPTESGKQEKAPAEDGMSAEL---------------------QGEANG-----LDEVKVE 79

  Fly  4808 NQICQLQQTAGPSPAKYNQPGSPGELRRTKSGHSLAVPKLYEAGIDKAQVSEKQRTVAAY----- 4867
            :|    ::..|...|:.......||...|..|......:..|...:..:..||:.|:|:.
Human    80 SQ----REAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAE 140

  Fly  4868 ------FSGQKSPTGG----------QVEELRTSMTTTTSSRKSAINRTK---TSEKLSAAARKS 4913
                  .||||:....          :.|:.:|:....|..||......|   |.|:..|.::|:
Human   141 EKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKA 205

  Fly  4914 LSSLTTTSNGNVSTAGLGMVVRGGGVGGIGGGAALSRSATMPHIANLNLLDESNVEDAFEQLMMA 4978
            :          |............|......||.                :|::.::..|....|
Human   206 V----------VEDEAKAEPKEPDGKEEAKHGAK----------------EEADAKEEAEDAEEA 244

  Fly  4979 QHKSSSSSEQRTETKSKDGGATVTTTTTKVTTRTVSGSAASKNISPLAKFKQLDKQAAAQ---QA 5040
            :..|.|..:::...|..:|||.|..::.:....:.:|...:.:...|..    |..|:.|   .|
Human   245 EPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGP----DCVASGQTSPSA 305

  Fly  5041 QKSSPT-----------------------TSTPTTP---------------GGSAQ---PLFKFT 5064
            .:|||:                       .|.|..|               ||:|.   .||:.|
Human   306 SESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNT 370

  Fly  5065 DPALNARAATVKDQLLQWCKHKTQEYENVQINNFSSSWSDGLAFCALIHHFLPDAFDYTTLTKQT 5129
             .|..|....||:.||:||:..|::||:|.|.|||||||.|:|||||||.|.||||||..|....
Human   371 -KAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAK 434

  Fly  5130 RRHNFELAFSVADEKAGIAPLLDVEDMVEMSRPDWKCVFVYVQSIYR 5176
            |||||.||||.|::.|..|.||||:|||.::.||.|||:.|:|.:||
Human   435 RRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYR 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981	61/101 (60%)
SMTNL1	NP_001099035.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..348		64/366 (17%)
		2A1904	<19..278	CDD:273344	52/292 (18%)
		CH	380..481	CDD:366016	60/100 (60%)
		Calmodulin-binding. /evidence=ECO:0000250	476..494		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4923
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001328
OrthoInspector	1	1.000	-	-		otm41222
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840