DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and DMP1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	XP_011530007.1	Gene:	DMP1 / 1758	HGNCID:	2932	Length:	542	Species:	Homo sapiens

Alignment Length:	517	Identity:	104/517 - (20%)
Similarity:	190/517 - (36%)	Gaps:	113/517 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  2883 YSDNKSPPRHERK-----------ELIYSSNADELAAIKQQLQDEDDSSPPLLDARVVREFKKVE 2936
            |.:|:|....|.|           |...||...::::.:|..:|..||:               :
Human    51 YQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDST---------------Q 100

  Fly  2937 SQQSL-PEDARYVRRGSVKELSEKFIRKESSSSTHSTHSSIAQSLVRHEDETEDDSESNDVCSVI 3000
            |::.| .:|.:|:.|     |:..|.|............         ||::.||:..:|...
Human   101 SEEGLGSDDHQYIYR-----LAGGFSRSTGKGGDDKDDD---------EDDSGDDTFGDDDSG-- 149

  Fly  3001 EAPQMRQ--NQSHTMSTTRSSNTRSFLNSSADQRQVTSVDDVLE--RMRNADNVE---EPGDSSE 3058
            ..|:.||  ..|...|...|.:|......||.|.|.::.|...|  .:.|.|.|:   |.|||::
Human   150 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQ 214

  Fly  3059 DREARALLNKFL------------GASVIMQGVESMLPPTATGQ----RLNSQGVKTTRITNTYS 3107
            :.|:.   ..::            |:.:..:|::|..|.:...:    |:||.|:|        |
Human   215 ESESE---EHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK--------S 268

  Fly  3108 KSGNSTSTTNNTSNT---------TNKV---SSSSAPVTRTTCD----IEEIWDEQVLKQLLEQA 3156
            |.....|...||.::         :.|:   |..|....|:..|    :||:..:..........
Human   269 KESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT 333

  Fly  3157 STYEERRKIRARLRELMAE---REEQKNLKQAPKEEKEE-----EESSASEYEEIIEE------- 3206
            ...:.||..:...:|...|   :||.:|:.....|..:|     :|:|:...||::.|
Human   334 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD 398

  Fly  3207 -VTDYSDEEEEVPPKKEEPKKEEVTKKEVTKKEVTTKQQEEIQQKAVKKVEKTETKTSQATESVS 3270
             .|.|.:::|:....:|:........|..:::|....:..|....:.:..|..|.:.|.:.|.:.
Human   399 PTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 463

  Fly  3271 KKLAKVELASSSSSSTTDGVQVQGESLPAKATKTGATGAAGPVSSSSIGSRKSSSLSSSQVS 3332
            ...:..|..|..|.|..|    ..:|..:..:|..:.......||...|..|:..:.|.:::
Human   464 SHSSSAESQSEESHSEED----DSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290	10/55 (18%)
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
DMP1	XP_011530007.1	DMP1	30..542	CDD:284637	104/517 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900