DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34417 and MUCL3

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_543146.2	Gene:	MUCL3 / 135656	HGNCID:	21666	Length:	1393	Species:	Homo sapiens

Alignment Length:	1580	Identity:	325/1580 - (20%)
Similarity:	530/1580 - (33%)	Gaps:	389/1580 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TQQHYEENKRYVDMDKASP---------EYQRHVQHLMEQPGEIIS-----------NTVEYPKP 368
            |.|.|::.......|...|         .:...|.|..::|.|:..           ||..:.||
Human    31 TFQEYQKTGELSTSDHIFPLTPGLVYSIPFDHIVLHSGQRPPELPKSTEIHEQKRHCNTTRHSKP 95

  Fly   369 NVKMITTVKRLPDGTIVKNKRYETEQLTPSQSHTTHKQTNNQTHNQTRNQVHNQRREQDEQDSQT 433
            ..|        |.|   .:|..:.:..|  .:|.....:...:.||.::.:...:|..|..||.|
Human    96 TDK--------PTG---NSKTIDHKSST--DNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTT 147

  Fly   434 RDVVDNVEQKHVTESQSFSSVKKSSRRFSTETTSETVEEYDDRDQPTSR---VVQKAPTPSYAPP 495
            .. .::..:||:|.:..    .|.:.|.||...|....:.|...:|..:   .:.|..|.|:...
Human   148 TH-KESAGKKHITPAPK----SKINCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTT 207

  Fly   496 S--HSPRQSPAKDFSTHGFPS--VRPNKAT----------QEYPSQRPGIAGEEVVVVRSEKSRQ 546
            :  |:...|..|..|| .||.  ...:|.|          ::....|..:|.::::
Human   208 TSFHNSGNSQTKQKST-SFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASDKLL--------- 262

  Fly   547 VKQQTSSQRTIETEVVGDDYQEP-QRSPQKLREAPTPSWEQPATRR-------------QPVEED 597
            .|...:.|.||....:.....|| :...:...|..|||..:|...|             :|:|.
Human   263 TKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPIEN- 326

  Fly   598 FSTHGFPSVRTTTTSTRPDQPDGEVLHTSKTVSRNQSANRKTNTERIIETQVEHPNAPSHSTPRS 662
                   ..||...:|.| .|.|      .|.:|..:||..|..         .|..|:....|:
Human   327 -------RERTANENTAP-FPAG------PTENREMTANENTTL---------FPAEPTEHGERT 368

  Fly   663 GSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTS--EPLTRRQLQKEREVDAAHRA 725
            .:...:                ||.:.|:..|..|..:.||.|  ||....:          ...
Human   369 ANENTT----------------PSPAEPTEHGERTANENTTPSPAEPTEHGE----------RTP 407

  Fly   726 FAASLRSSSPADST-----TSVGSHHQTPRSSVSSNRTFRREMREGSHDSQAPSESSRISSTTVT 785
            ||....:||.|:||     |.:.:.:.||.   .:..|..||.....:.:.:|:..:....||..
Human   408 FANDKTTSSSAESTEHGERTPLANENTTPS---PAEPTENRERTANENTTPSPAGPTENRETTAN 469

  Fly   786 RHTTGGNVTSNTIKTKTTKPVKTASEPRSPTPKAGGSVTTTTTTITTKSSPSPAP-ASPTTAAPP 849
            ..||...| ..|...:||...||...|..||  ..|..|......||.||..|.. ...|..|..
Human   470 EKTTLSPV-EPTENRETTANEKTTPSPAEPT--ENGQRTPFANEKTTSSSAEPTEHGERTPLANE 531

  Fly   850 TSAPASSAPPDNKLSQYTYTTTKPGDIFSLPPTTPPTINNEPTLTTTRNTTTTTTTTTTATSDNL 914
            .:.|:.:.|.:|:.......||        |....||.|.:.|......||
Human   532 NTTPSPAEPTENRERTANEKTT--------PSPAEPTENGDRTPLANEKTT-------------- 574

  Fly   915 QNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQYYQLGNEGENPETPESSGTPANK 979
                 .|..||..:....|....|.:::.|:     |....:...|.||...|       :||..
Human   575 -----PSLAEPTENGQRTPFANEKTTSSSAE-----PTEHEERTPLANENTTP-------SPAEP 622

  Fly   980 KPHQMRRPHDEPEPQLRRSSKSPSVEPRQV--QRETTFEGRRVSQDREISIDELILIEETSGAPG 1042
            ..::.|..::...|     |.:...|.|::  ..:||......:::||.:.:     |:|:.:|.
Human   623 TENRERTANENTTP-----SPAGPTENREMTANEKTTLFPAEPTENRERTAN-----EKTTSSPA 677

  Fly  1043 SPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQFPRARSPE 1107
            .|.....|.....:..|.|.        |.|.:..|:...|.:.|  ..:|::|.:...|..:.:
Human   678 EPTENGQRTPFANEKTTSSS--------AEPTEHGERTPLANENT--TLSPAEPTENRERTANEK 732

  Fly  1108 KTPGWTQPQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPR 1172
            .||       .|.: |.:...|..:....|:..||:                 :.|...|..:.:
Human   733 TTP-------FPAE-PTENRERTANENTTPSPAQPT-----------------ENGDRTPLANEK 772

  Fly  1173 QSPEKQLPKDVPQKSRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQPI 1237
            .:|....|.:..:::..:.||..::.....|...|:.:  ..:.||::..|     ..:|:.:..
Human   773 TTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPL--ANENTTSSPAE-----PTENRERTA 830

  Fly  1238 SEKKPQIPANAEPNTKPSETIESPDGGFPSKTTEVEAQP-EVKESPTYRKKGLTRRETFEDRCRQ 1301
            :||..|.||      :|:|..||...   .|||...|:| |.:|........|:..|..|.....
Human   831 NEKTTQFPA------EPTENRESTAN---EKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMT 886

  Fly  1302 ILGMEEDGDTQGTYTERPNNEQEDVNVSHTTIETIQVKIEDCPNDDEDDKPRRVTETYVVRTQP- 1365
            .|..|:...:....||  |.|:.......||..:.:      |.:..:..|.....|...|.:|
Human   887 PLANEKTTLSPAEPTE--NGERTPFTNEKTTPSSAE------PTEHGERTPLANEITTPSRAEPT 943

  Fly  1366 ----KIKVEEELFVDVTEAEDVEILVN----PSKKSPKEEDSPKYPKGPETPKSPRNDQRIPS-I 1421
                :|..|:.........|..|..||    ||...|.|       .|..||.:..|....|: .
Human   944 EHGERIANEKATPSPAKPTEHGETTVNEDTTPSSAEPTE-------NGERTPLANENTTTSPTES 1001

  Fly  1422 PKKGQSPVQFKTEETPRYPQEQ-ERYPKEPETSQYPKESPRNPKEDAE-TININEETT---IVIT 1481
            .:.|:.....||..:|..|.|. ||.|...|.: .|  ||..|.|..| |.:.||.||   :..|
Human  1002 TEHGERTANEKTTPSPAEPTEHGERTPSANEKT-IP--SPAKPTEHEEMTPSANENTTPSPVKPT 1063

  Fly  1482 KEGSKS--PSPRWSPSPERRVPKSQQPPSPTASPSVSPVSGRKIPNEVESNFVTEKIIDCRGKTV 1544
            :.|.|:  .:.:.:.|||.  |......:.:|:..::|...:...:...:....:||.    .:.
Human  1064 EHGEKTTLANEKITLSPEG--PTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKIT----SSA 1122

  Fly  1545 VEKISQRPR-------TPSPTTPKKNTKPSQKIPERVPETESEPEKDSESETKKTTSVSVTKTET 1602
            .|....|.|       ||:|..|.|:.|.:....|::.:.   .||.:| ..:||||.:
Human  1123 AESTEHRDRATSANVITPAPAEPIKHAKRTTLAHEKMTQV---TEKSTE-HPEKTTSTT------ 1177

  Fly  1603 ERRNSRTTKTKQPLPLKEPQSKVPAGKSPRKDSLTGRKRDSLVEETRITTTTTTTRQGRKPSDTN 1667
                .:||:|.:                          :.:|..|..|.|....|....||::..
Human  1178 ----EKTTRTPE--------------------------KPTLYSEKTICTKGKNTPVPEKPTENL 1212

  Fly  1668 GSPSIKDRLRSSPRKQKTSPQQTRTPTPAQTRNPEDDVDGDSSSPDASPTRVGNERRRSSNISVH 1732
            |:.::......:|.|...:|::|...|  :|..|...|.||.|....|
Human  1213 GNTTLTTETIKAPVKSTENPEKTAAVT--KTIKPSVKVTGDKSLTTTS----------------- 1258

  Fly  1733 TEIIIDHMAPKSPKTERRSQGGTGNVPSPIRKLPVTERKESAPVPRVTRRDKAEKVTRSTSENII 1797
                                       |.:.|..||.:..:.....:|.|.|...:|.
Human  1259 ---------------------------SHLNKTEVTHQVPTGSFTLITSRTKLSSITS------- 1289

  Fly  1798 KMSGTKPHPEMSSLKPGGDR 1817
            :.:|.:.||.::  |.|..:
Human  1290 EATGNESHPYLN--KDGSQK 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
MUCL3	NP_543146.2	Atrophin-1	<299..820	CDD:331285	133/662 (20%)
MUCL3	NP_543146.2	LGT	<916..1062	CDD:320995	41/161 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900