DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and Dmp1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001345942.1	Gene:	Dmp1 / 13406	MGIID:	94910	Length:	503	Species:	Mus musculus

Alignment Length:	518	Identity:	108/518 - (20%)
Similarity:	196/518 - (37%)	Gaps:	108/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  2868 ETKQEVTGYVIEEQFYSDNKSPPRHERKELIYSSNADELAAIKQQLQDEDDSSPPLLDARVVREF 2932
            |:.:|.||.:.        .|||.....|   ||...:.:...|...|..|||
Mouse    28 ESSEERTGDLA--------GSPPPPTNSE---SSEESQASPEGQANSDHTDSS------------ 69

  Fly  2933 KKVESQQSLPED-ARYVRRGSVKELSEKFIRKESSSSTHSTHSSIAQSLVRHEDETEDDS---ES 2993
               ||.:.|..| .:|...|.:.:.:.....||..                 ||::.||:   |.
Mouse    70 ---ESGEELGYDRGQYRPAGGLSKSTGTGADKEDD-----------------EDDSGDDTFGDED 114

  Fly  2994 NDVCSVIEAPQMRQ--------NQSHTMSTTRSSNTRSFLNSSADQRQVTSVDDVLERMRNADNV 3050
            ||:     .|:..|        :...:..||:||...:...:||......|.|...|  ..||:.
Mouse   115 NDL-----GPEEGQWGGPSKLDSDEDSTDTTQSSEDSTSQENSAQDTPSDSKDHDSE--DEADSR 172

  Fly  3051 EEPGDSSEDRE---------ARALLNKFLGASVIMQGVESMLPPTATGQ----RLNSQGVKTTRI 3102
            .|.|||::|.|         :....:...|:....:|::|..|.:....    |::|.|:::.
Mouse   173 PEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGHARMSSAGIRSE-- 235

  Fly  3103 TNTYSKSGNSTSTTNNTSNTTNKVSSSSAPVTRTTCDIEEIWDEQVLKQLLEQAS--TYEERRKI 3165
                ...|:...|:...|:.:..|..||....|.:    .:.:|....:|.:..|  |..:..:.
Mouse   236 ----ESKGDHEPTSTQDSDDSQSVEFSSRKSFRRS----HVSEEDYRGELTDSNSRETQSDSTED 292

  Fly  3166 RARLRELMAEREEQKNLKQAPKEEKEEEESSASEYEEIIEEVTDYSDEEEEVPPKKEEPKKEEVT 3230
            .|...|..:|.:|.....|:.::..|.::.|:...||..|...:.|.|.:|....:......:.|
Mouse   293 TASKEESRSESQEDTAESQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVTSESRGDNPDNT 357

  Fly  3231 KKEVTKKEVTTKQQEEIQQKAVKKVEKTETKT-SQATESVSKKLAKVELASSSSSSTTDGVQVQG 3294
            .:...:::..:.:::.:...:..:.:.||.:. |::.||:|......|.|....||:.:|:|.|.
Mouse   358 SQAGDQEDSESSEEDSLNTFSSSESQSTEEQADSESNESLSLSEESQESAQDGDSSSQEGLQSQS 422

  Fly  3295 ESLPAKATKTGATGAAGPVSSSSIGSRKSSSLSSSQVSTVVRARDKAKPEMMPVAGTGSGSES 3357
            .|..:::.:           |.|....:|...|.||.|:  |:::::.       .|||.|.|
Mouse   423 ASTESRSQE-----------SQSEQDSRSEEDSDSQDSS--RSKEESN-------STGSASSS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290	9/50 (18%)
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
Dmp1	NP_001345942.1	DMP1	1..503	CDD:311295	108/518 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..503		108/518 (21%)
		Cell attachment site. /evidence=ECO:0000255	350..352		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900