DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34417 and LEO1

DIOPT Version :9

Sequence 1:	NP_001259282.1	Gene:	CG34417 / 31591	FlyBaseID:	FBgn0085446	Length:	5182	Species:	Drosophila melanogaster
Sequence 2:	NP_001310832.1	Gene:	LEO1 / 123169	HGNCID:	30401	Length:	688	Species:	Homo sapiens

Alignment Length:	760	Identity:	148/760 - (19%)
Similarity:	249/760 - (32%)	Gaps:	216/760 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1187 SRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQPISEKKPQIPANAEPN 1251
            |.|...|:|......:|.....:.:......::|.:|   .:||.:..........|...:..||
Human    53 SGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSE---ASERSDHEDNDPSDVDQHSGSEAPN 114

  Fly  1252 TKPSETIESPDGGFPSKTTEVEAQPEVKESPTYRKKGLTRRETFEDRC--RQILGMEEDGDTQGT 1314
            ....|...| |||    :...||:...|......|.|   ||...|:.  .:|...:::...||:
Human   115 DDEDEGHRS-DGG----SHHSEAEGSEKAHSDDEKWG---REDKSDQSDDEKIQNSDDEERAQGS 171

  Fly  1315 YTERPNNEQEDVNVSHTTIETIQVKIEDCPNDDEDDKPRRVTETYVVRTQPKIKVEEELFVDVTE 1379
            ..::..|..:|               |...|.|::::|                   :|..|..:
Human   172 DEDKLQNSDDD---------------EKMQNTDDEERP-------------------QLSDDERQ 202

  Fly  1380 AEDVEILVNPSKKSPKEEDSPKYPKGPETPKSPRNDQRIPSIPKKGQSPVQFKTEETPRYPQEQE 1444
            ....|...|...:.|...|:       :..|...:|:..|.:  ..:..:|...:|.|:...|:.
Human   203 QLSEEEKANSDDERPVASDN-------DDEKQNSDDEEQPQL--SDEEKMQNSDDERPQASDEEH 258

  Fly  1445 RYPKEPETSQYPKESPRNPKEDAETININEETTIV----------ITKEGS-------------- 1485
            |:..:.|...:..||.|....:.|.:.:..:..|.          :.|:.|
Human   259 RHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISS 323

  Fly  1486 ------KSPSPRWSPSPERRVPKSQQPPSPTAS-------PSVSPVSGR-----KIPNEV----- 1527
                  |.|:| ..|..|..:|:.||...|...       |.|:...|.     |:||.:
Human   324 GSDGEDKPPTP-GQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPR 387

  Fly  1528 -------ESNFVTEKIIDCRGKTVVEKISQRPRTPSPTTPKKNTKPSQKIPERVPETESEPE-KD 1584
                   |..|..|:::|..|:|                 :...|....|..|:...|...| |:
Human   388 PFDPQYYEDEFEDEEMLDEEGRT-----------------RLKLKVENTIRWRIRRDEEGNEIKE 435

  Fly  1585 SESETKKTTSVSVT------------------------KTETERRNSRTTKTKQPLPLKEPQSKV 1625
            |.:...|.:..|::                        :..|..:.....|||...   .|.|..
Human   436 SNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTF---RPHSTD 497

  Fly  1626 PAGKSPRKDSLTGRKRDSLVEETRITTTTTTTRQGRKPSDTNGSPSIK---DRLRSSPRKQKTSP 1687
            .|  :.||.:|:...|.|..::.||....     ||.| :...:..||   :|||:|.|::.
Human   498 SA--THRKMTLSLADRCSKTQKIRILPMA-----GRDP-ECQRTEMIKKEEERLRASIRRES--- 551

  Fly  1688 QQTRTPTPAQTRNPEDDVDGDSSSPDASPTRVGNERRRSSNISVHTEIIIDHMAPKSPKTERRSQ 1752
            ||.|.......|.        .|:....|.|...|.....:||:             ...:.|.:
Human   552 QQRRMREKQHQRG--------LSASYLEPDRYDEEEEGEESISL-------------AAIKNRYK 595

  Fly  1753 GGTGNVPSPIRKLPVTERKE--SAPVPRVTRRDKAEKVTRSTSENIIKMSGTKPHPEMSSL--KP 1813
            ||       ||:    ||..  |:.....:..|||:::.::......:.||.:..|::...  :.
Human   596 GG-------IRE----ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEESGKRERPKLKETWRQW 649

  Fly  1814 GGDRSRP--SKCCTTKTINLSEQRINTATDIEGVIIDIQQAKSSR 1856
            .|:.|||  |.....:.:||.|:        |...:.|:|.||.|
Human   650 KGEVSRPTLSFLRQNRKVNLPER--------EKQKMMIKQIKSIR 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34417	NP_001259282.1	Smoothelin	2594..2636	CDD:289290
		Smoothelin	3127..3176	CDD:289290
		GBP_C	<3810..3882	CDD:303769
		coiled coil	3857..3868	CDD:293879
		CH	5076..5179	CDD:237981
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..357		65/358 (18%)
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..583		9/46 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900