DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dx and Dtx2

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001243025.1	Gene:	Dtx2 / 74198	MGIID:	1921448	Length:	619	Species:	Mus musculus

Alignment Length:	773	Identity:	219/773 - (28%)
Similarity:	304/773 - (39%)	Gaps:	222/773 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MALSTAGSGGPPVNHAH-AVCVWEF-ESRGKWLPYSPAV----SQHLER-----------AHAKK 75
            ||::.: |..|.|..:| .|.|||: :..|.|.|||..|    .||..|           ||:
Mouse     1 MAMAPS-SSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQHFVRQRGQHFGLGSLAHS-- 62

  Fly    76 LTRVMLSDADPSLEQYYVNVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSA 140
               :.|..|||||..|.:::.:.||..:    .:|.:. .|||..::.:|..|:|..|||.|
Mouse    63 ---IPLGQADPSLAPYIIDLPSWTQFRQ----NTGTMR-SVRRHLFSQNSAPGQGIVWEWLG--- 116

  Fly   141 DSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQA 205
             .:..|..|...:...:|...|||.|.:||  ..:|..||:|:..|||..:.|...||:||....
Mouse   117 -DDGSWVAYEARICDYLEQQVARGIQVVDL--APLGYNYTVNYATLTQTNKTSSFCRSVRRQVGP 178

  Fly   206 PYPLVK--LTPQQANQL--------KSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSHQ 260
            .||:..  ..|:|...:        .|.:..||.:|.        .|:..:|    .:|.|
Mouse   179 VYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYR--------HSMTNLP----AYPAP---- 227

  Fly   261 VQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPP-----KKHSEISTTN 320
                          |..|........||              ..||...|     :....::|||
Mouse   228 --------------QAPHRTTTVSGAHQ--------------AFAPYNKPSLSGARSAPRLNTTN 264

  Fly   321 ----LRQILNNLNIFSSSTKHQSNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNSH 381
                ...:..|.::|.||..| .......|..|:||.||                    ||..|.
Mouse   265 PWAAAPPVAGNQSLFHSSLSH-LGPQLLPSGPSTSSGAS--------------------ASFPSG 308

  Fly   382 HSRCSEGS------LQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVS--TYLSHESK 438
            .|..|.||      :|..::||:....:...:..|........|...||:....|  ...||.|.
Mouse   309 PSSSSPGSAPTTVPVQMPKASRVQQALAGMTSVLSAIGLPVCLSRAPRPTGPPASRPASKSHSSV 373

  Fly   439 ESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQQQLQMQ 503
            :.||.                           .|:.|.||.|.|       :|..::..::|:
Mouse   374 KRLRK---------------------------MSVKEGAPKPEP-------EQVIRKYTEELK-- 402

  Fly   504 QQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEELV----------HS 558
                               |.|..|                   |.:|||:|.          ..
Mouse   403 -------------------VAPEED-------------------CIICMEKLAVASGYSDMTDSK 429

  Fly   559 AQNPAI--SLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSII 621
            |..|.:  .|::|.|..||.||    :|.....||:..::||.|..:||||.|.||.|.|.....
Mouse   430 ALGPMVVGRLTKCSHAFHLLCL----LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRF 490

  Fly   622 SKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFDR 686
            ..:|||||...||.|||:|..|:|..|||.||:.|.|.||||.|||||.|.|||||..||:|:.|
Mouse   491 QMSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWKR 555

  Fly   687 RLLFSIGRSVTTGREDVVIWNSVDHKTQFNM------FPDPTYLQRTMQQLVHLGVTD 738
            ||:|::|.|.|||..|.|:||.:.|||:.:.      :|||.|||..:.:|...|||:
Mouse   556 RLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	27/94 (29%)
		WWE	133..209	CDD:128922	26/75 (35%)
		RING	548..600	CDD:238093	19/63 (30%)
		Deltex_C	609..735	CDD:193607	66/131 (50%)
Dtx2	NP_001243025.1	WWE	21..105	CDD:128922	27/93 (29%)
		WWE	110..181	CDD:128922	25/76 (33%)
		PHA03247	<204..392	CDD:223021	55/286 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..271		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..328		15/65 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..389		12/60 (20%)
		RING-H2_DTX2	408..479	CDD:319586	25/93 (27%)
		RING-H2 finger (C3H2C3-type)	409..469	CDD:319586	19/63 (30%)
		DTC	477..611	CDD:375551	66/133 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4734
eggNOG	1	0.900	-	-		E1_2CMG8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2782
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47472
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm43134
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4547
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.960