DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dx and Dtx1

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_006249474.1	Gene:	Dtx1 / 687424	RGDID:	1585380	Length:	631	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	200/786 - (25%)
Similarity:	305/786 - (38%)	Gaps:	225/786 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PGGGGSAASSCATMALSTAGSGGPPVNHAHAVCVWEF-ESRGKWLPYSPAVSQHLERAHAKKLTR 78
            ||.|         :.:...|.|.||.|.|..| |||: ....:|.||:..|..|:|.. .|:..|
  Rat     4 PGQG---------VMVPVNGLGFPPQNVARVV-VWEWLNEHSRWRPYTATVCHHIENV-LKEDAR 57

  Fly    79 --VMLSDADPSLEQYYVNVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEW--SGGS 139
              |:|...|..|..|.:::::|.|..:    .:|.:. .|||.||.|||..|||..|||  .||:
  Rat    58 GSVVLGQVDAQLVPYIIDLQSMHQFRQ----DTGTMR-PVRRNFYDPSSAPGKGIVWEWENDGGA 117

  Fly   140 ADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQ 204
                  |..|:|.:...|::|:.:....|||  :.:|..|.|.|.:::|:.:.:...|.:||...
  Rat   118 ------WTAYDMDICITIQNAYEKQHPWLDL--SSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLD 174

  Fly   205 APYPLV--KLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSHQVQQQQHQ 267
            ..|||.  .:...|:..:.::|....|....| .:..|::.....:..|:...|.:
  Rat   175 LAYPLTVGSIPKSQSWPVGASSGQPCSCQQCL-LVNSTRAASNAILASQRRKAPIA--------- 229

  Fly   268 HQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEISTTNLRQILNNLNIFS 332
                                               ..||..||.....:........|
  Rat   230 -----------------------------------PAAPPAPPPPPPPLPPGGPPSAL------- 252

  Fly   333 SSTKHQSNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNSHHSRCSEGSLQSQRSSR 397
                       ....|::.:.|:|..|........:....:...|.::.:...:.|   ....||
  Rat   253 -----------VVRPSATFAGAALWAAPAAGPTEPAPPPGVPPRSPSAPNGAPTPG---QNNLSR 303

  Fly   398 MGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTYLSHESKESLRSRNFAISVNDLLDCSLGSDE 462
            .|..||           .||.:....|.
  Rat   304 PGPQRS-----------TSVSARASIPP------------------------------------- 320

  Fly   463 VFVPSLPPSSLGERAPVPP----------------------PLP-LHPRQQQQ------------ 492
             .||:||..:|....||.|                      |.| |||....:
  Rat   321 -GVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGV 384

  Fly   493 -QQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFV-KVVEPPLWPNAQPCPMCMEEL 555
             ::.:::.|:..:..:                    |::.|:: ||..||    .:.|.:|||.|
  Rat   385 CRKTKKKHLKKSKNPE--------------------DVVRRYMQKVKNPP----DEDCTICMERL 425

  Fly   556 VHSA------QNPAI------SLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKV 608
            |.::      :|.::      .|.||.|:.||.||..|........:|:..::||.|..:||||.
  Rat   426 VTASGYEGVLRNKSVRPELVGRLGRCGHMYHLLCLVAMYSNGNKVGHKDGSLQCPTCKAIYGEKT 490

  Fly   609 GNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLG 673
            |.||.|.|.:.:|..:|||.....||:|||||.:|:|..|||:||:.|.|.||||.||||:...|
  Rat   491 GTQPPGKMEFHLIPHSLPGFADTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKG 555

  Fly   674 RKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNM------FPDPTYLQRTMQQLV 732
            |||||.|..|::|||:|:||.|.|||..|.|:||.:.|||:|..      :||.:||...:.:|.
  Rat   556 RKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELT 620

  Fly   733 HLGVTD 738
            ..||::
  Rat   621 AQGVSE 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	26/81 (32%)
		WWE	133..209	CDD:128922	22/77 (29%)
		RING	548..600	CDD:238093	19/63 (30%)
		Deltex_C	609..735	CDD:193607	64/131 (49%)
Dtx1	XP_006249474.1	WWE	26..102	CDD:128922	27/82 (33%)
		WWE	107..>163	CDD:128922	18/63 (29%)
		RING-H2_DTX1_4	415..487	CDD:319585	20/71 (28%)
		DTC	490..624	CDD:407937	64/133 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4634
eggNOG	1	0.900	-	-		E1_2CMG8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I2992
OMA	1	1.010	-	-		QHG47472
OrthoDB	1	1.010	-	-		D271375at33208
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm45202
orthoMCL	1	0.900	-	-		OOG6_105304
Panther	1	1.100	-	-	O	PTHR12622
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880