Protein Alignment dx and dtx2

DIOPT Version :9

• Sequence 1: NP_511064.2
• Gene: dx / 31589
• FlyBaseID: FBgn0000524
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001120779.1
• Gene: dtx2 / 568626
• ZFINID: ZDB-GENE-081022-150
• Length: 566
• Species: Danio rerio
• Alignment Length: 767
• Identity: 192/767 - (25%)
• Similarity: 289/767 - (37%)
• Gaps: 251/767 - (32%)

  Fly     9 ASGSVVPGGGGSAAS--SCATMALSTAGSGGPPVNHAHAVCVWEF-ESRGKWLPYSPAVSQHLE- 69
            |:||..|.||....:  |.|:.:.|:..|.|.|........|||: :..|.|.||:..||.::|
Zfish     2 ATGSSFPSGGSGTRNGPSFASPSTSSVTSSGVPGQAQPMAVVWEWQDDLGFWRPYTGQVSSYIEQ 66

  Fly    70 -----RAHAKKLTRVMLSDADPSLEQYYVNVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGK 129
                 |..|...:.:.|:.|||||..|.:::..:.|..:    .:|.:. .|||..:..||..|.
Zfish    67 CLQHQRGAAVAGSSICLAQADPSLSSYIIDIPNLKQFRQ----DTGKMR-AVRRSLFPQSSALGS 126

  Fly   130 GTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSG 194
            |..||||    :..:.|..|.:....::|.::..|:.|.|| :.| |..|.::...|.|:.:.:.
Zfish   127 GVLWEWS----NDESGWTAYEIRTSILLEHSYQAGQATADL-SPH-GYNYIVDLGALEQVNKATS 185

  Fly   195 PMRSIRRTQQAPYPLVKLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSH 259
            ..|.:||....||||.             |.||               :|..|
Zfish   186 YRRRVRRQGNVPYPLA-------------SGSV---------------IHSGP------------ 210

  Fly   260 QVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEISTTNLRQI 324
                                                                             
Zfish   211 ----------------------------------------------------------------- 210

  Fly   325 LNNLNIFSSSTKHQ--SNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNSHHSRCSE 387
                    :.|.||  :|.|||....|.|             .|...|...:..|:.:.|.|..
Zfish   211 --------ACTCHQCVTNSSTAGPMLSRS-------------RHSFSAGQAIRPSLQTQHGRLP- 253

  Fly   388 GSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTYLSHESKESLRSRNFAISVND 452
                                 .:.:.::....:.|||                       :|:..
Zfish   254 ---------------------VTSSSSSGYSPYPRRP-----------------------LSMGS 274

  Fly   453 LLDCSLGSDEVFV--PSLPPSSLGERAP--VPPPLPLHPRQQQQQQQQQQQLQMQQQQQAQQQQQ 513
            ||.....|....|  |:.||.:.|..:.  ..|.:|||                       ....
Zfish   275 LLWNGPWSAPPSVPHPTGPPQNFGHHSNGLSIPTIPLH-----------------------MNGS 316

  Fly   514 QSIAGSIVGVDPA---SDMISRFVKVVEPPLWPNAQPCPMCME------------ELVHSAQNPA 563
            .|:..::..  ||   .::|.::::  |.|:.|: :.|.:|||            |...|.|...
Zfish   317 SSVNSALAA--PAQKPEEVIKKYME--EVPVVPD-EDCIICMERLSCPSGYEVPAECSQSLQPST 376

  Fly   564 I-SLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSIISKNLPG 627
            : .|::|.|..|:.|:    :|..|...|:..::||.|..:||||.|.||.|.|....|.::|||
Zfish   377 VGKLTKCAHTFHMLCM----LAMYNNGTKDGSLQCPSCKTIYGEKTGTQPKGKMEIYSIPQSLPG 437

  Fly   628 HEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFDRRLLFSI 692
            |....||||:|:|..|:|..|||:||:.:...||||.|:|||...|||||..||:|:.|||:|::
Zfish   438 HPDCGTIQIIYNIPPGIQGPEHPNPGQPYTCRGFPRFCFLPDNDKGRKVLELLKVAWTRRLIFTV 502

  Fly   693 GRSVTTGREDVVIWNSVDHKTQF------NMFPDPTYLQRTMQQLVHLGVTD 738
            |.|.|||..|.||||.:.|||:.      :.:|||.||...:.:|...|||:
Zfish   503 GTSSTTGEPDTVIWNEIHHKTEMMSNVSGHGYPDPNYLDNVLSELASQGVTE 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	25/85 (29%)
		WWE	133..209	CDD:128922	21/75 (28%)
		RING	548..600	CDD:238093	17/64 (27%)
		Deltex_C	609..735	CDD:193607	62/131 (47%)
dtx2	NP_001120779.1	WWE domain	34..115		23/85 (27%)
		WWE	42..115	CDD:280915	22/77 (29%)
		WWE domain	116..192		21/81 (26%)
		WWE	127..192	CDD:280915	18/70 (26%)
		proline-rich region	264..294		9/52 (17%)
		RING	348..412	CDD:238093	18/67 (27%)
		RING-H2 domain	349..410		17/64 (27%)
		Deltex_C	419..551	CDD:193607	62/131 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4482
eggNOG	1	0.900	-	-		E1_2CMG8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47472
OrthoDB	1	1.010	-	-		D271375at33208
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm25199
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.890