DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dx and Dtx3

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001178918.1	Gene:	Dtx3 / 500847	RGDID:	1566181	Length:	347	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	117/387 - (30%)
Similarity:	170/387 - (43%)	Gaps:	107/387 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 LQSQRSSRMGSHRSRSRTRTS---DTDTNSV----KSHRRRPSVDTVSTYLSHES-----KESLR 442
            |..:..:|:.  |.|...|.|   |.:|:.:    .|.:..|.......||:.::     ||:.:
  Rat    29 LSKETPARLA--RLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEK 91

  Fly   443 SRNFAISVNDLLDC-SLGS----DEVF---------VPSLPPSSLGERAPVPP-PLPLHPRQQQQ 492
            ....|....:|:.| :||.    .|:.         .|.|||.:.|...|.|| |.||.||.::.
  Rat    92 ELKKAQRQGELMGCLALGGGGEHPELHRPGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLRED 156

  Fly   493 QQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEELVH 557
            .::|:                                                ..||:|:.|:
  Rat   157 AEEQE------------------------------------------------TTCPICLGEI-- 171

  Fly   558 SAQNPAISLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQP-IGSMSWSII 621
              || |.:|.:|:|.....|:...:..::         .||:||..||:.||||| .|.|   ::
  Rat   172 --QN-AKTLEKCRHSFCEGCITRALQVKK---------ACPMCGRFYGQLVGNQPQNGRM---LV 221

  Fly   622 SKN----LPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKI 682
            ||:    ||.:|...||.|.|....|:|..|||:||..:  .|..|:.||||||.|.|||...:.
  Rat   222 SKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRY--PGTTRVAYLPDCPEGNKVLTLFRK 284

  Fly   683 AFDRRLLFSIGRSVTTGREDVVIWNSVDHKT------QFNMFPDPTYLQRTMQQLVHLGVTD 738
            |||:||.|:||.|:||||.:|:.||.:.|||      |...:||||||.|..::|...|:||
  Rat   285 AFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922
		WWE	133..209	CDD:128922
		RING	548..600	CDD:238093	13/51 (25%)
		Deltex_C	609..735	CDD:193607	62/136 (46%)
Dtx3	NP_001178918.1	RING-HC_DTX3	163..203	CDD:319625	13/53 (25%)
Dtx3	NP_001178918.1	DTC	210..344	CDD:407937	63/138 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910