DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dx and dtx2

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_998834.1	Gene:	dtx2 / 407940	XenbaseID:	XB-GENE-984000	Length:	592	Species:	Xenopus tropicalis

Alignment Length:	779	Identity:	200/779 - (25%)
Similarity:	301/779 - (38%)	Gaps:	253/779 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PGGGGSAASSCATMALSTAGSGGPPVNHAHA-VCVWEF-ESRGKWLPYSPAVSQHLE-------- 69
            ||||..:.|...|::           |..:| |.|||: :...||.|||.|||.::|
Frog     7 PGGGVPSFSGLPTVS-----------NQWNASVAVWEWQDEHNKWRPYSSAVSNYIEQYMVSYSQ 60

  Fly    70 ----RAHAKKLTRVMLSDADPSLEQYYVNVRTMTQ-ESEAETAGSGLLTIGVRRMFYAPSSPAGK 129
                ||:... ..:.|..|||.|..|.:::.|::| ..:..|..|      ||:..||..|...|
Frog    61 QKGFRAYGNS-NSISLGKADPKLAPYIIDIPTLSQFRQDTGTMRS------VRKSLYASDSAPAK 118

  Fly   130 GTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSG 194
            |..|||....|    .|..|.|.:...:::.:......:||  ...||||..:..:..|:.:.:|
Frog   119 GISWEWMNDEA----CWTAYEMPITIYLDENYCNRRPLVDL--GAFGLPYQADLNSGIQINKMTG 177

  Fly   195 PMRSIRRTQQAPYPLV-------KLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQ 252
            ..|.|:|....||||.       |......:|..:|||:           |.....||..|..
Frog   178 FRRQIQRRADIPYPLTSAMGPVHKSAACLCHQCLANSAA-----------GPISGRHRHSMIN-- 229

  Fly   253 HPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEIS 317
              ||||                                                     ..|::|
Frog   230 --LPTS-----------------------------------------------------SGSQLS 239

  Fly   318 TTNLRQILN---------NLNIFSSSTKHQSNMSTA------ASASSSSSSASLHHANHLSHAHF 367
            .|:.....|         ::.|..|:.|..|...|:      ...||||:..|:
Frog   240 RTSFASSFNVGYVPYPKPSMAISKSTPKLNSTWLTSPVPLQFPGPSSSSNGTSI----------- 293

  Fly   368 SHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTY 432
                                                                    ||: .|:|.
Frog   294 --------------------------------------------------------PSI-PVNTQ 301

  Fly   433 LSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQ 497
            ..:.:|::|      ..:..:|..:.|....|..:.|||:        ||:...|.:.....::.
Frog   302 KQNSTKQAL------AGMTAILMSAAGLPVRFTSAPPPSN--------PPVNSKPDKNHNSVRKL 352

  Fly   498 QQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEEL-VHSAQN 561
            :  :|.::..|.:.::               ::.::::.||.|  |. :.|.:|||.| |.|..:
Frog   353 R--KMPKKGTATEPEK---------------VVKKYLENVEKP--PE-EDCIICMETLNVASGYS 397

  Fly   562 PAI-----------SLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGS 615
            .|:           .|.:|.|..|..|    ::|..|..||:..::||.|..:||||.|.||.|:
Frog   398 DAVECKNIKPTAVGKLKKCGHTFHQLC----VLAMYNNGNKDGSLQCPACKTIYGEKTGTQPKGN 458

  Fly   616 MSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFL 680
            |.:|:|.::||||:...||.|||.|..|.|...||:||:.:.|.||||.|||||...||.||..|
Frog   459 MEYSLIPQSLPGHQDCGTIHIVYTIHPGTQGPGHPNPGKPYSARGFPRHCYLPDNEKGRLVLELL 523

  Fly   681 KIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNM------FPDPTYLQRTMQQLVHLGVTD 738
            |:|:.|||:|:||.|.|||..|.|:||.:.|||:.|.      :|||.|:...:.:|...|||:
Frog   524 KLAWARRLIFTIGVSSTTGESDTVVWNEIHHKTEMNSNISGHGYPDPNYMDNVVAELAAQGVTE 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	28/92 (30%)
		WWE	133..209	CDD:128922	20/75 (27%)
		RING	548..600	CDD:238093	19/63 (30%)
		Deltex_C	609..735	CDD:193607	63/131 (48%)
dtx2	NP_998834.1	WWE	28..106	CDD:280915	25/84 (30%)
		WWE	119..184	CDD:280915	18/70 (26%)
		RING	382..445	CDD:238093	20/66 (30%)
		Deltex_C	452..584	CDD:193607	63/131 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4750
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2901
OMA	1	1.010	-	-		QHG47472
OrthoDB	1	1.010	-	-		D271375at33208
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm48267
Panther	1	1.100	-	-	LDO	PTHR12622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4547
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110