Protein Alignment dx and dtx2

DIOPT Version :10

• Sequence 1: NP_511064.2
• Gene: dx / 31589
• FlyBaseID: FBgn0000524
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_998834.1
• Gene: dtx2 / 407940
• XenbaseID: XB-GENE-984000
• Length: 592
• Species: Xenopus tropicalis
• Alignment Length: 779
• Identity: 200/779 - (25%)
• Similarity: 301/779 - (38%)
• Gaps: 253/779 - (32%)

  Fly    15 PGGGGSAASSCATMALSTAGSGGPPVNHAHA-VCVWEF-ESRGKWLPYSPAVSQHLE-------- 69
            ||||..:.|...|::           |..:| |.|||: :...||.|||.|||.::|
 Frog     7 PGGGVPSFSGLPTVS-----------NQWNASVAVWEWQDEHNKWRPYSSAVSNYIEQYMVSYSQ 60

  Fly    70 ----RAHAKKLTRVMLSDADPSLEQYYVNVRTMTQ-ESEAETAGSGLLTIGVRRMFYAPSSPAGK 129
                ||:... ..:.|..|||.|..|.:::.|::| ..:..|..|      ||:..||..|...|
 Frog    61 QKGFRAYGNS-NSISLGKADPKLAPYIIDIPTLSQFRQDTGTMRS------VRKSLYASDSAPAK 118

  Fly   130 GTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSG 194
            |..|||....|    .|..|.|.:...:::.:......:||  ...||||..:..:..|:.:.:|
 Frog   119 GISWEWMNDEA----CWTAYEMPITIYLDENYCNRRPLVDL--GAFGLPYQADLNSGIQINKMTG 177

  Fly   195 PMRSIRRTQQAPYPLV-------KLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQ 252
            ..|.|:|....||||.       |......:|..:|||:           |.....||..|..
 Frog   178 FRRQIQRRADIPYPLTSAMGPVHKSAACLCHQCLANSAA-----------GPISGRHRHSMIN-- 229

  Fly   253 HPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEIS 317
              ||||                                                     ..|::|
 Frog   230 --LPTS-----------------------------------------------------SGSQLS 239

  Fly   318 TTNLRQILN---------NLNIFSSSTKHQSNMSTA------ASASSSSSSASLHHANHLSHAHF 367
            .|:.....|         ::.|..|:.|..|...|:      ...||||:..|:
 Frog   240 RTSFASSFNVGYVPYPKPSMAISKSTPKLNSTWLTSPVPLQFPGPSSSSNGTSI----------- 293

  Fly   368 SHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTY 432
                                                                    ||: .|:|.
 Frog   294 --------------------------------------------------------PSI-PVNTQ 301

  Fly   433 LSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQ 497
            ..:.:|::|      ..:..:|..:.|....|..:.|||:        ||:...|.:.....::.
 Frog   302 KQNSTKQAL------AGMTAILMSAAGLPVRFTSAPPPSN--------PPVNSKPDKNHNSVRKL 352

  Fly   498 QQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEEL-VHSAQN 561
            :  :|.::..|.:.::               ::.::::.||.|  |. :.|.:|||.| |.|..:
 Frog   353 R--KMPKKGTATEPEK---------------VVKKYLENVEKP--PE-EDCIICMETLNVASGYS 397

  Fly   562 PAI-----------SLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGS 615
            .|:           .|.:|.|..|..|    ::|..|..||:..::||.|..:||||.|.||.|:
 Frog   398 DAVECKNIKPTAVGKLKKCGHTFHQLC----VLAMYNNGNKDGSLQCPACKTIYGEKTGTQPKGN 458

  Fly   616 MSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFL 680
            |.:|:|.::||||:...||.|||.|..|.|...||:||:.:.|.||||.|||||...||.||..|
 Frog   459 MEYSLIPQSLPGHQDCGTIHIVYTIHPGTQGPGHPNPGKPYSARGFPRHCYLPDNEKGRLVLELL 523

  Fly   681 KIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNM------FPDPTYLQRTMQQLVHLGVTD 738
            |:|:.|||:|:||.|.|||..|.|:||.:.|||:.|.      :|||.|:...:.:|...|||:
 Frog   524 KLAWARRLIFTIGVSSTTGESDTVVWNEIHHKTEMNSNISGHGYPDPNYMDNVVAELAAQGVTE 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	28/92 (30%)
		WWE	133..209	CDD:128922	20/75 (27%)
		RING_Ubox	547..601	CDD:473075	19/65 (29%)
		Deltex_C	609..735	CDD:193607	63/131 (48%)
dtx2	NP_998834.1	WWE	30..106	CDD:460715	24/82 (29%)
		WWE	122..184	CDD:460715	17/67 (25%)
		RING-H2_DTX2	382..453	CDD:438334	24/74 (32%)
		DTC	451..585	CDD:465650	63/133 (47%)