DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dx and Dtx2

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001100627.1	Gene:	Dtx2 / 304591	RGDID:	1561790	Length:	619	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	214/774 - (27%)
Similarity:	302/774 - (39%)	Gaps:	224/774 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MALSTAGSGGPPVNHAH-AVCVWEF-ESRGKWLPYSPAVSQHLER---------------AHAKK 75
            ||::.: |..|.|..:| .|.|||: :..|.|.|||..|...:|:               ||:
  Rat     1 MAMAPS-SSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQQFIRQRGQHFGLGSLAHS-- 62

  Fly    76 LTRVMLSDADPSLEQYYVNVRTMTQ-ESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGS 139
               :.|..|||||..|.:::.:.|| ..:..|..|      |||..::.:|..|:|..|||.|
  Rat    63 ---IPLGQADPSLAPYIIDLPSWTQFRQDTGTMRS------VRRHLFSQNSAPGQGIVWEWLG-- 116

  Fly   140 ADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQ 204
              .:..|..|...:...:|...|||.|.:||  ..:|..||:|:..|||..:.|...||:||...
  Rat   117 --DDGSWIAYEARICDYLEQQVARGIQVVDL--APLGYNYTVNYATLTQTNKTSSFCRSVRRQVG 177

  Fly   205 APYPLVK--LTPQQANQL--------KSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSH 259
            ..||:..  ..|:|...:        .|.:..||.:|.        .|:..:|    .:|.|
  Rat   178 PVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYR--------HSMTNLP----AYPAP--- 227

  Fly   260 QVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPP-----KKHSEISTT 319
                           |..|........||              ..||...|     :....::||
  Rat   228 ---------------QAPHRTATVSGAHQ--------------AFAPYNKPSLSGARSAPRLNTT 263

  Fly   320 N----LRQILNNLNIFSSSTKHQSNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNS 380
            :    ...:..|.::..||..|.......:..|:||.:                     :||..|
  Rat   264 SPWGATPPVPGNQSLLHSSLSHLGPQLLPSGPSTSSGT---------------------SASFPS 307

  Fly   381 HHSRCSEGS------LQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVS--TYLSHES 437
            ..|..|.||      :|..:.||:....:...:..|........|...||:....|  |..||.|
  Rat   308 GPSSSSPGSAPTTVPVQMPKPSRVQQALAGMTSVLSAIGLPVCLSRAPRPTGPPASRPTSKSHSS 372

  Fly   438 KESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQQQLQM 502
            .:.||.                           .|:.|.||.|.|       :|..::..::|:
  Rat   373 VKRLRK---------------------------MSVKEGAPKPEP-------EQVIRKYTEELK- 402

  Fly   503 QQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEELV----------H 557
                                |.|..|                   |.:|||:|.          .
  Rat   403 --------------------VAPEED-------------------CIICMEKLSVASGYSDVTDS 428

  Fly   558 SAQNPAI--SLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSI 620
            .|..|.:  .|::|.|..||.||    :|.....||:..::||.|..:||||.|.||.|.|....
  Rat   429 KALGPMVVGRLTKCSHAFHLLCL----LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFR 489

  Fly   621 ISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFD 685
            ...:|||||...||.|||:|..|:|..|||.||:.|.|.||||.|||||.|.|||||..||:|:.
  Rat   490 FHMSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWK 554

  Fly   686 RRLLFSIGRSVTTGREDVVIWNSVDHKTQFNM------FPDPTYLQRTMQQLVHLGVTD 738
            |||:|::|.|.|||..|.|:||.:.|||:.:.      :|||.|||..:.:|...|||:
  Rat   555 RRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	26/95 (27%)
		WWE	133..209	CDD:128922	26/75 (35%)
		RING	548..600	CDD:238093	19/63 (30%)
		Deltex_C	609..735	CDD:193607	66/131 (50%)
Dtx2	NP_001100627.1	WWE	21..105	CDD:128922	26/94 (28%)
		WWE	110..181	CDD:128922	25/76 (33%)
		PHA03247	<204..392	CDD:223021	51/286 (18%)
		RING-H2_DTX2	408..479	CDD:319586	25/93 (27%)
		DTC	477..611	CDD:407937	66/133 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4634
eggNOG	1	0.900	-	-		E1_2CMG8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I2992
OMA	1	1.010	-	-		QHG47472
OrthoDB	1	1.010	-	-		D271375at33208
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm45202
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12622
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.940