Protein Alignment dx and Dtx4

DIOPT Version :10

• Sequence 1: NP_511064.2
• Gene: dx / 31589
• FlyBaseID: FBgn0000524
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_766030.3
• Gene: Dtx4 / 207521
• MGIID: 2672905
• Length: 616
• Species: Mus musculus
• Alignment Length: 739
• Identity: 202/739 - (27%)
• Similarity: 297/739 - (40%)
• Gaps: 177/739 - (23%)

  Fly    43 AHAVCVWEF-ESRGKWLPYSPAVSQHLE---RAHAKKLTRVMLSDADPSLEQYYVNVRTMTQESE 103
            |.||.|||: ...|:|.|||||||.|:|   ||..:....|:|...|..|..|.:::::|.|..:
Mouse     4 ASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQ 68

  Fly   104 AETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTL 168
                .:|.|. .|||.:|.|||..|||..|||.    :.|..|.||:|.|...|:.|:.:....:
Mouse    69 ----DTGTLR-PVRRNYYDPSSAPGKGVVWEWE----NDNGSWTPYDMEVGITIQYAYEKQHPWI 124

  Fly   169 DLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSNSASVSSQYNT 233
            ||  |.||..|.|:|..:.|:.:.:...|.:||.....||:|.                    .|
Mouse   125 DL--TSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVT--------------------GT 167

  Fly   234 LPKLGDTKSLHRVPMTRQQHPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHH 298
            :||   |:|....|......|.|..                          ...|......::..
Mouse   168 MPK---TQSWPVSPGPATSSPAPPC--------------------------SCPQCVLVMSVKAA 203

  Fly   299 QIHHQTAPRKPPKKHSEISTTNLRQILNNLNIFSSSTKHQSNMSTAASASSSSSSASLHHANHLS 363
            .:|..|.|....|..:......|.|                  .....|....::.::.
Mouse   204 VVHGGTGPPAVRKNMALSGVGKLPQ------------------PPGPGAKPLDTTGTIR------ 244

  Fly   364 HAHFSHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDT 428
                ...|...:..:....|....|:.....:|..||:|...|...:..:.:::
Mouse   245 ----GPGKTAPSQVIRRQVSNAPAGATVGSPASPQGSNRKTGRVALATLNRSNL----------- 294

  Fly   429 VSTYLSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPV-------------- 479
                           :..||:.:.:|..|      .||::|..:|...:||
Mouse   295 ---------------QRLAIAQSRVLIAS------GVPTVPVKNLNGSSPVNPALAGITGILMSA 338

  Fly   480 ---------PPPLPLHPRQQQQQQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVK 535
                     ||.|.|||....:.:.:.........::..::|.:.      |..|...:.....|
Mouse   339 AGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKK------GKTPEEVLKKYLQK 397

  Fly   536 VVEPPLWPNAQPCPMCMEELV----HSAQNPAI------SLSRCQHLMHLQCLNGMIIAQQNEMN 590
            |..||    .:.|.:|||.|.    :....|.:      .||||.|:.|:.||    :|..|..|
Mouse   398 VRHPP----EEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHIYHIYCL----VAMYNNGN 454

  Fly   591 KNLFIECPVCGIVYGEKVGNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRA 655
            |:..::||.|..:||.|.|.||.|.|.:.:|..:||||....||:|:|.|..|:|..|||:||::
Mouse   455 KDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKS 519

  Fly   656 FFAVGFPRICYLPDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNM--- 717
            |.|.||||.|||||...|||||:.|.:|:||||:|:||.|.|||..|.||||.|.|||:|..
Mouse   520 FSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLT 584

  Fly   718 ---FPDPTYLQRTMQQLVHLGVTD 738
               :||..||...:.:|...|:::
Mouse   585 GHGYPDANYLDNVLAELAAQGISE 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	31/82 (38%)
		WWE	133..209	CDD:128922	24/75 (32%)
		RING_Ubox	547..601	CDD:473075	20/63 (32%)
		Deltex_C	609..735	CDD:193607	66/131 (50%)
Dtx4	NP_766030.3	WWE	8..86	CDD:128922	31/82 (38%)
		WWE	92..144	CDD:460715	20/57 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..254		4/58 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..387		3/37 (8%)
		RING-H2_DTX1_4	403..469	CDD:438333	21/69 (30%)
		DTC	472..606	CDD:465650	66/133 (50%)