DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dx and DTX2

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001096064.1	Gene:	DTX2 / 113878	HGNCID:	15973	Length:	622	Species:	Homo sapiens

Alignment Length:	732	Identity:	204/732 - (27%)
Similarity:	296/732 - (40%)	Gaps:	171/732 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AVCVWEF-ESRGKWLPYSPAVSQHLER---------------AHAKKLTRVMLSDADPSLEQYYV 93
            ||.|||: :..|.|.|||..|...:|:               ||:     :.|..|||||..|.:
Human    18 AVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHS-----IPLGQADPSLAPYII 77

  Fly    94 NVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSADSNNDWRPYNMHVQCIIE 158
            ::.:.||..:    .:|.:. .|||..:...|..|:|..|||    ...:..|..|...|...:|
Human    78 DLPSWTQFRQ----DTGTMR-AVRRHLFPQHSAPGRGVVWEW----LSDDGSWTAYEASVCDYLE 133

  Fly   159 DAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSN 223
            ...|||.|.:||  ..:|..||:|:...||..:.|...||:||....|||:..:.....:   :.
Human   134 QQVARGNQLVDL--APLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGH---TG 193

  Fly   224 SASVSSQYNTLPKLGDTKSLHRVPMTR-QQHPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQH 287
            .|....|..:..:.|.....:|..||. ..:|:|            ||...:.......||
Human   194 VACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVP------------QHPPHRTASVFGTHQ---- 242

  Fly   288 QQQQQHQMQHHQIHHQTAPRKPPKKHSEISTTNLRQILNNLNIFSSSTKHQSNMSTAASASSSSS 352
                           ..||...|......|...|                  |.:.|..|:..|.
Human   243 ---------------AFAPYNKPSLSGARSAPRL------------------NTTNAWGAAPPSL 274

  Fly   353 SASLHHANHLSHAHFSHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSV 417
            .:...:.:.|||....|      ....|..|.....||.|..||..||..:            :|
Human   275 GSQPLYRSSLSHLGPQH------LPPGSSTSGAVSASLPSGPSSSPGSVPA------------TV 321

  Fly   418 KSHRRRPSVDTVSTYLSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVP-- 480
            .....:||                |.:.....:..:|..::|.         |..| .|||.|
Human   322 PMQMPKPS----------------RVQQALAGMTSVLMSAIGL---------PVCL-SRAPQPTS 360

  Fly   481 PPLPLHPRQQQQQQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASD-MISRFVKVVEPPLWPN 544
            ||              ..:|..:.....::.::.|:.|:....:|..: :|..:.:.::.|  |:
Human   361 PP--------------ASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVP--PD 409

  Fly   545 AQPCPMCMEELVHSA------QNPAIS------LSRCQHLMHLQCLNGMIIAQQNEMNKNLFIEC 597
             :.|.:|||:|..::      .:.||.      |::|.|..||.||    :|.....||:..::|
Human   410 -EDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCL----LAMYCNGNKDGSLQC 469

  Fly   598 PVCGIVYGEKVGNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFP 662
            |.|..:||||.|.||.|.|.......:|||||...||.|||.|..|:|..|||:||:.|.|.|||
Human   470 PSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFP 534

  Fly   663 RICYLPDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNM------FPDP 721
            |.|||||...|||||..||:|:.|||:|::|.|.|||..|.|:||.:.|||:.:.      :|||
Human   535 RQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDP 599

  Fly   722 TYLQRTMQQLVHLGVTD 738
            .|||..:.:|...|||:
Human   600 NYLQNVLAELAAQGVTE 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	25/94 (27%)
		WWE	133..209	CDD:128922	26/75 (35%)
		RING	548..600	CDD:238093	19/63 (30%)
		Deltex_C	609..735	CDD:193607	65/131 (50%)
DTX2	NP_001096064.1	WWE	21..105	CDD:128922	25/93 (27%)
		WWE	110..181	CDD:128922	25/76 (33%)
		Atrophin-1	<166..394	CDD:331285	60/337 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..324		21/110 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..393		9/51 (18%)
		RING-H2_DTX2	411..482	CDD:319586	24/74 (32%)
		RING-H2 finger (C3H2C3-type)	412..472	CDD:319586	19/63 (30%)
		Deltex_C	481..613	CDD:193607	65/131 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4753
eggNOG	1	0.900	-	-		E1_2CMG8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2808
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47472
OrthoDB	1	1.010	-	-		D271375at33208
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm41063
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4547
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.970