DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dx and si:dkey-3h3.3

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001116534.1	Gene:	si:dkey-3h3.3 / 100144568	ZFINID:	ZDB-GENE-060526-299	Length:	441	Species:	Danio rerio

Alignment Length:	465	Identity:	117/465 - (25%)
Similarity:	180/465 - (38%)	Gaps:	132/465 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 HAHFSHAKNMLTASMNSHHSRCSE--------GSLQS-----------QRSSRMGSHRSRSRTRT 409
            |.......|.:|:.:|....|.::        |..|.           |.:.....|..:.....
Zfish    16 HPAIFQPPNSVTSILNGKTIRVTQKEDYLIATGKFQDIKDFYKSCIKIQTTHNRPKHPKQQEMSM 80

  Fly   410 SDTDTNSVKSHRRRPSV-------DTVSTYLSHESK---ESLRSRNFAISVNDLLDCSLGSDEVF 464
            |...|.|..|.:..|||       |||..|:..:..   |:::.|: .:|:|     :..:...|
Zfish    81 SSHTTASPGSAQNDPSVFDPIKVDDTVMQYIKEKKSKEFEAIQKRH-GVSIN-----TFKNYLTF 139

  Fly   465 VPSLPPSSLGERAPVPPPLPLHPRQQQQQ-----QQQQQQLQMQQQQQ----------------- 507
            .|....:             :|.:..:::     |:....||::....
Zfish   140 TPQTGKN-------------IHAQFAREEFITLYQKIAIGLQIRNHNYRRDIFEFCSSEFPELLI 191

  Fly   508 --AQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLW------------------PNAQP----- 547
              :..::|..:.|..:.::       ||...::...|                  |..||
Zfish   192 NLSSDRKQMQLIGDFISLE-------RFDTCLKGSDWRRYSLHQTPSRTMTHYDTPRTQPAKHEK 249

  Fly   548 ---------CPMCMEELVHSAQNPAISLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIV 603
                     ||:|:|.:   ....:..|::|||.....||:...         .|...||:||.:
Zfish   250 TSDQAKDETCPICLETI---KMPESTVLTKCQHRFCKDCLDTAF---------QLKPACPICGEI 302

  Fly   604 YGEKVGNQPI-GSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYL 667
            ||...|.||. |:|:.|.....|||::|..||.|.|.|.||.|..|||:||..:.  |..||.||
Zfish   303 YGSLTGTQPKGGTMTVSRDRSCLPGYKGYGTIVITYYIPSGSQGVEHPNPGMPYH--GASRIAYL 365

  Fly   668 PDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFN------MFPDPTYLQR 726
            ||...|..||:.|:.|||:||.|:||||.|||:.:||.||.:.|||..:      .:|||.||:|
Zfish   366 PDSTEGTHVLKLLQRAFDQRLTFTIGRSSTTGKNNVVTWNDIHHKTSRDGGPTHYGYPDPDYLKR 430

  Fly   727 TMQQLVHLGV 736
            ...:|...|:
Zfish   431 VQDELKAKGI 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922
		WWE	133..209	CDD:128922
		RING	548..600	CDD:238093	13/51 (25%)
		Deltex_C	609..735	CDD:193607	61/132 (46%)
si:dkey-3h3.3	NP_001116534.1	zf-RING_2	257..299	CDD:290367	13/53 (25%)
si:dkey-3h3.3	NP_001116534.1	Deltex_C	308..439	CDD:193607	61/132 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910