DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dx and dtx4b

DIOPT Version :9

Sequence 1:	NP_511064.2	Gene:	dx / 31589	FlyBaseID:	FBgn0000524	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_002660570.1	Gene:	dtx4b / 100037355	ZFINID:	ZDB-GENE-070410-129	Length:	731	Species:	Danio rerio

Alignment Length:	813	Identity:	232/813 - (28%)
Similarity:	340/813 - (41%)	Gaps:	211/813 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AHAVCVWEF-ESRGKWLPYSPAVSQHLERAHAKKLTR-------VMLSDADPSLEQYYVNVRTMT 99
            |.||.|||: ...|:|.|||||||.|:|     ::.|       |:|..||..|..|.:::::|.
Zfish     7 ASAVVVWEWLNEHGRWRPYSPAVSHHIE-----EVIRSDPRGGSVVLGQADSRLSPYIIDLQSMH 66

  Fly   100 QESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARG 164
            |..:    .:|.|. .|||.||.|:|..|:|..|||.    :....|..|:|.|...::.||.|.
Zfish    67 QFRQ----DTGTLR-PVRRSFYDPTSAPGQGWIWEWE----NDTGSWITYDMEVSIALQAAWDRH 122

  Fly   165 EQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSNSASVSS 229
            :..||:  |.:|..|.::|..:.|..:.:...|.|:|.....||||      :..|..||.:..|
Zfish   123 QPWLDM--TSMGFCYFVDFKTMIQFNRQTQRQRRIQRRSDMVYPLV------SGPLPKNSQAWGS 179

  Fly   230 QY-------NTLPKLGDTKSLHRVPMTRQQHPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQH 287
            ..       ..:...|.|.:|..|
Zfish   180 ALGAGGIAKGVISGAGSTGALLGV----------------------------------------- 203

  Fly   288 QQQQQHQMQHHQIHHQTAPRKPPKKH--SEISTTNL---------RQILNNLNIFSSSTKHQ--- 338
                       .:...|..||....:  ..:|.::|         :|.:..|::.|:.|..|
Zfish   204 -----------GVSGSTLSRKGSAVYPSGTLSVSSLAPLGQPCACQQCMLVLSVKSNGTSSQTLG 257

  Fly   339 ---------SNMSTAASASSSSS-----SASLHHANHLSHAHFSHAKN------MLTA-----SM 378
                     ||..|.:|:|:|.|     |.:|.|...|..:....|||      :||:     |:
Zfish   258 RATKPNSPKSNFGTLSSSSASMSVLNSYSQTLPHGTSLKSSPSEEAKNFDQSLSLLTSGTASLSV 322

  Fly   379 NSHHSRCSE-------GSLQSQRSSRMGSHRSRSRTRTS---DTDTNSVKSHRRRPSVDTVSTYL 433
            :|...|...       .||..|..|..||..|.|...|:   :|.||...|.....|..|:.:..
Zfish   323 SSSRPRLPSLPPPPNLPSLNQQPPSASGSSSSASFVPTAVLVNTSTNPTSSTVLTSSTTTLPSQR 387

  Fly   434 SHESKESL--RSRNFAISVNDLLDCSLGSDEVF----VPSLPPSSLGERAPV------------- 479
            |......|  |:....:|...|...::......    ||::|..:|...:||
Zfish   388 STACAAPLPPRASLAGLSRPALQRIAMAQSRALIASGVPTVPVKNLNGSSPVQPALAGITGILMS 452

  Fly   480 ----------PPPLPLHPRQQQQQQQQQ-----QQLQMQQQQQAQQQQQQSIAGSIVGVDPASDM 529
                      ||.|.|||....:...:.     ...:...::||::           |..| .::
Zfish   453 AAGLPVCLTRPPKLVLHPPPVSKSDIRPIPGIGHCCRKTTKKQARK-----------GKTP-EEV 505

  Fly   530 ISRFV-KVVEPPLWPNAQPCPMCMEEL--VHSAQNPAIS----------LSRCQHLMHLQCLNGM 581
            :.|:: ||..||    .:.|.:|||.|  ....:.|.::          |::|.||.|||||
Zfish   506 VKRYLQKVRSPP----EEDCTICMEALGGPSGYKGPGVASVSRAESVGRLAQCGHLYHLQCL--- 563

  Fly   582 IIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQT 646
             :|..|..||:..::||.|..:||.|.||||.|.|.:.:|..:||||....||:|:|:|..|:|.
Zfish   564 -VAMYNNGNKDGSLQCPTCKTIYGVKTGNQPAGKMEYHVIPHSLPGHPDCKTIRIIYNIPPGIQG 627

  Fly   647 EEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDH 711
            .|||:|.:.|.|.||||.|||||...||||||.|.:|:||||:||:|.|.|||..|.||||.:.|
Zfish   628 PEHPNPAKPFTARGFPRHCYLPDNEKGRKVLRLLLVAWDRRLIFSVGTSSTTGESDTVIWNEIHH 692

  Fly   712 KTQFNM------FPDPTYLQRTMQQLVHLGVTD 738
            ||:|..      :||..||...:::|...|:|:
Zfish   693 KTEFGSNLTGHGYPDSGYLDHVLEELKAQGITE 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dx	NP_511064.2	WWE	47..126	CDD:128922	31/86 (36%)
		WWE	133..209	CDD:128922	21/75 (28%)
		RING	548..600	CDD:238093	21/63 (33%)
		Deltex_C	609..735	CDD:193607	66/131 (50%)
dtx4b	XP_002660570.1	WWE	11..88	CDD:128922	31/86 (36%)
		WWE	92..146	CDD:280915	18/59 (31%)
		RING	520..583	CDD:238093	22/66 (33%)
		Deltex_C	590..722	CDD:193607	66/131 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4482
eggNOG	1	0.900	-	-		E1_2CMG8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2904
OMA	1	1.010	-	-		QHG47472
OrthoDB	1	1.010	-	-		D271375at33208
OrthoFinder	1	1.000	-	-		FOG0001598
OrthoInspector	1	1.000	-	-		otm25199
orthoMCL	1	0.900	-	-		OOG6_105304
Panther	1	1.100	-	-	O	PTHR12622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1153
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840