DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spat and agxt-1

DIOPT Version :9

Sequence 1:	NP_511062.1	Gene:	Spat / 31587	FlyBaseID:	FBgn0014031	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_495885.1	Gene:	agxt-1 / 174414	WormBaseID:	WBGene00011767	Length:	405	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	169/381 - (44%)
Similarity:	243/381 - (63%)	Gaps:	3/381 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PPLVLKRPLYVPSKTLMGPGPSNCSHRVLEAMSNPVLGHMHPECLQIMDEVKEGIKYIFQTLNDA 69
            ||..|.:.:.||.:.|.||||||.:..:.|..|..:|||:|||.:|||.:|:.|::|:|:|.|..
Worm    27 PPKALLQDMVVPPRQLFGPGPSNMADSIAETQSRNLLGHLHPEFVQIMADVRLGLQYVFKTDNKY 91

  Fly    70 TMCISGAGHSGMEAALCNLIEDGDVVLMGITGVWGHRAGDMARRYGAEVHYVEASFGRALSHEEI 134
            |..:||.||||||.|:.||:|.||..|:...|:||.||.|:|.|.|.||..:.|..|:|:..|:|
Worm    92 TFAVSGTGHSGMECAMVNLLEPGDKFLVVEIGLWGQRAADLANRMGIEVKKITAPQGQAVPVEDI 156

  Fly   135 TFAFEAHRPKVFFIAQGDSSTGIIQQNIRELGELCRKYDCFLIVDTVASLGGTEFLMDEWKVDVA 199
            ..|...::|.:.|:.|||||||:.|. :..:|:.||::....:||||||||||.|..|:.|||..
Worm   157 RKAIADYKPNLVFVCQGDSSTGVAQP-LETIGDACREHGALFLVDTVASLGGTPFAADDLKVDCV 220

  Fly   200 YTGSQKSLGGPAGLTPISFSKRALTRIRKRKTKPKVYYFDILLIGQYWGCYGTPRIYHHTISSTL 264
            |:.:||.|..|.||.|||||.||:.:||.||.:...:|||.:.:|.||||.|..:.||||...:.
Worm   221 YSATQKVLNAPPGLAPISFSDRAMEKIRNRKQRVASFYFDAIELGNYWGCDGELKRYHHTAPIST 285

  Fly   265 LYGLREALAHFCAVGLKAVVRRHQECSKRLQLGIEELGLEMFVSREEERLPTVNTIKVPFGVDWK 329
            :|.||.||:.....|:...::||::.::.|...:::.|||.||..|:.|||.:.|:|||.|||||
Worm   286 VYALRAALSAIAKEGIDESIQRHKDNAQVLYATLKKHGLEPFVVDEKLRLPCLTTVKVPEGVDWK 350

  Fly   330 KVAEYAMRKYSVEISGGLGPTVEHVFRIGLMGENATVERVDMVLSILNEAI-QSSK 384
            .||...|.. ..||:||||.||..::|||..|.|:...:::.|:.:|:::| :.||
Worm   351 DVAGKMMTN-GTEIAGGLGATVGKIWRIGTFGINSNSTKIENVVELLSKSIGEKSK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spat	NP_511062.1	PucG	16..389	CDD:223153	165/370 (45%)
Spat	NP_511062.1	AGAT_like	19..381	CDD:99744	162/362 (45%)
agxt-1	NP_495885.1	AAT_I	42..382	CDD:302748	157/341 (46%)
agxt-1	NP_495885.1	PhnW-AepZ	42..381	CDD:274512	157/340 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167931
Domainoid	1	1.000	297	1.000	Domainoid score	I787
eggNOG	1	0.900	-	-		E1_COG0075
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37251
Inparanoid	1	1.050	332	1.000	Inparanoid score	I1426
Isobase	1	0.950	-	0	Normalized mean entropy	S2200
OMA	1	1.010	-	-		QHG61020
OrthoDB	1	1.010	-	-		D289834at33208
OrthoFinder	1	1.000	-	-		FOG0003987
OrthoInspector	1	1.000	-	-		oto19288
orthoMCL	1	0.900	-	-		OOG6_100588
Panther	1	1.100	-	-	LDO	PTHR21152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2022
SonicParanoid	1	1.000	-	-		X3850
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750