DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3342 and GOLGA8A

DIOPT Version :9

Sequence 1:	NP_572324.1	Gene:	CG3342 / 31586	FlyBaseID:	FBgn0029874	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001373822.1	Gene:	GOLGA8A / 23015	HGNCID:	31972	Length:	603	Species:	Homo sapiens

Alignment Length:	492	Identity:	92/492 - (18%)
Similarity:	159/492 - (32%)	Gaps:	168/492 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NLRQI----FEDDDRPLANESSSLRYQPGSSKKLQAGKRPA-------MTRSSTQETGDSPPAAW 77
            |.|.|    ..|..:.|..:...:.:|....||....|:.|       :.|.:|::      ...
Human    79 NSRSIKISRLNDTIKSLKQQKKQVEHQLEEEKKANNEKQKAERELEGQIQRLNTEK------KKL 137

  Fly    78 NTAIAKVVHAYR-----SSENVGRVGLALSILGEMEASKLIV----------YRSKSQVLTTLQL 127
            ||.:..:.|:.|     |.:..||:..:...:||:|.|...|          :.|:|:.|...||
Human   138 NTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQL 202

  Fly   128 TPRGGKVIL------------------RESYLQFYDDEQRFWSLRFDKEPDEKEFITFMVKNKLP 174
            .....:.||                  |:.|.:....|:..|..|..|...|   :..:.:.|..
Human   203 EQSIREQILLKGHVTQLKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQE---VCTLKEEKKH 264

  Fly   175 VEHYLSEISSSSSASPSREDLSKIRTKATVTKTTPNPPQ-PQPRSRVTLPTLEKADDEERERETE 238
            ..|.:.|:..|         ||:::.:    ...|.||. |...|.|.|..|.|
Human   265 DTHRVEELERS---------LSRLKNQ----MAEPLPPDAPAVSSEVELQDLRK----------- 305

  Fly   239 TPSNEDVIVTPVPRPIGSSNAHRKLSASSLAVANASTSSDTPLAVTTLDKYLDEQRASGALM-EH 302
                                                                :.:|.:|.|. :.
Human   306 ----------------------------------------------------ELERVAGELQAQV 318

  Fly   303 KMDAILQAMNRMGGQSSVAPKKPSDPLLERDSEDEMLELEQKLLNLKRENRALMRNLKAREQALE 367
            :.:..:..:||  ||....          |:.|:.:.|.:::|    ||....::.|...:..||
Human   319 ENNQCISLLNR--GQKERL----------REQEERLQEQQERL----REREKRLQQLAEPQSDLE 367

  Fly   368 DLRC-SACALCEELLVQNGELKSQNAQLLLASQHISDSSTAASPAHCRNCESSS-----RQIAKM 426
            :|:. :..||  :|..|..||:.:..|::...........||.||.....|||.     .:.|.:
Human   368 ELKHENKSAL--QLEQQVKELQEKLGQVMETLTSAEKEPEAAVPASGTGGESSGLMDLLEEKADL 430

  Fly   427 QLHISAL-------------QEALRIFQKSGDSSSSS 450
            :.|:..|             |:..|:..:.|||:..:
Human   431 REHVEKLELGFIQYRRERCHQKVHRLLTEPGDSAKDA 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3342	NP_572324.1	None
GOLGA8A	NP_001373822.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82		1/2 (50%)
		SMC_prok_B	78..>439	CDD:274008	87/462 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125		6/29 (21%)
		GOLGA2L5	218..>397	CDD:405716	46/275 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..419		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..492		3/8 (38%)
		Golgi-targeting domain	491..603
		GM130_C	558..603	CDD:408816
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900