DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpV and SIT4

DIOPT Version :9

Sequence 1:	NP_001259272.1	Gene:	PpV / 31582	FlyBaseID:	FBgn0003139	Length:	303	Species:	Drosophila melanogaster
Sequence 2:	NP_010236.1	Gene:	SIT4 / 851513	SGDID:	S000002205	Length:	311	Species:	Saccharomyces cerevisiae

Alignment Length:	286	Identity:	185/286 - (64%)
Similarity:	231/286 - (80%)	Gaps:	2/286 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DKWIEDVKKCKYLPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQV 69
            |:|:|.:|||:.|.|||:|:|||||.::|:||:||.||.|||||||||||||:||.:||||.|..
Yeast     7 DEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGF 71

  Fly    70 P-HTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGN 133
            | ..||||:||:||||||||||||.|:.||.:||::|||:|||||:||||:||||::||.:|||:
Yeast    72 PDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGS 136

  Fly   134 ANGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPE 198
            ...|||||:|||.||:|||||.::|||||||||||..|||||.:.|..|:|::|.|.||:||||:
Yeast   137 TTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPD 201

  Fly   199 DMEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGK-LVTVWSAPNYCYR 262
            ::|.|..||||||||||..|.::|..:|.||||.||||||.||.||.|..| :||||||||||||
Yeast   202 NVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKDVVTVWSAPNYCYR 266

  Fly   263 CGNVAAILSFETAEKRQTKIFLAVPD 288
            |||||:::..:...:...|||.||||
Yeast   267 CGNVASVMKVDEDLEPTFKIFSAVPD 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpV	NP_001259272.1	PTZ00239	3..303	CDD:173488	185/286 (65%)
PpV	NP_001259272.1	MPP_PP2A_PP4_PP6	3..287	CDD:277360	182/283 (64%)
SIT4	NP_010236.1	MPP_PP2A_PP4_PP6	7..291	CDD:277360	182/283 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346357
Domainoid	1	1.000	59	1.000	Domainoid score	I2618
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68273
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S176
OMA	1	1.010	-	-		QHG53795
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103044
Panther	1	1.100	-	-	LDO	PTHR45619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R960
SonicParanoid	1	1.000	-	-		X2805
TreeFam	1	0.960	-	-
	14	13.690