DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpV and ppef1

DIOPT Version :9

Sequence 1:	NP_001259272.1	Gene:	PpV / 31582	FlyBaseID:	FBgn0003139	Length:	303	Species:	Drosophila melanogaster
Sequence 2:	XP_021335306.1	Gene:	ppef1 / 559132	ZFINID:	ZDB-GENE-080303-27	Length:	729	Species:	Danio rerio

Alignment Length:	447	Identity:	106/447 - (23%)
Similarity:	157/447 - (35%)	Gaps:	180/447 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VDKWIEDVKKCKY----LPEN--------------------------------------ELKKLC 26
            ||...|:|::.||    :||:                                      |.||
Zfish   103 VDPLTEEVRQLKYEQIMVPESYSGPRLSFPLSVTDTNALLSAFKEEQTLHGKYVLQLLYETKK-- 165

  Fly    27 EMVCDILLEETNILPVST----PVTVCGDIHGQFYDLEQLFRTGGQVPHTN-YIFMGDFVDRGYY 86
                 .|.:..|::.:||    .:|:|||:||:..||..:|...|.....| |||.|||||||..
Zfish   166 -----FLKQMPNVIYLSTSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKK 225

  Fly    87 SLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNANG---WKYCCKVFDLLT 148
            |.|....|......||..:.|.|||||...:...|||..|...|| ..:|   .:....||.||.
Zfish   226 STEIIIILFAFVLLYPDHMHLNRGNHEDHIMNLRYGFTREVMQKY-KTHGREILQLLQDVFSLLP 289

  Fly   149 IAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNG-------------------------------- 181
            :|.:||.:||.||||:|.: ..||.:.|::|:.
Zfish   290 VATVIDNKVLIVHGGISDK-TDLDFLSTVERHKVKSALRLPKRSTDHLTVRSCSRSSSRNRGRNS 353

  Fly   182 ---------------------------------------------------------EIPYKGAF 189
                                                                     ::|:..:|
Zfish   354 RSSSRHSSRSRRKKLSKQGSRSSSSSSSSSSSSSMCSPRVSAKNTPRRPPPSPTDMLQVPFLDSF 418

  Fly   190 ------------------CDLVWSDPEDMEYWGQSP---RGAGWLFGHNVTKDFMAINNLNLICR 233
                              .|::||||:...  |.||   ||.|..||.:||:..:..:.|.|:.|
Zfish   419 VSLEPPELPREELEWQQVVDILWSDPKHQN--GCSPNSFRGGGCYFGPDVTQTLLQKHGLCLLIR 481

  Fly   234 AHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILS---------FETAEKRQTK 281
            :|:...||.:...:|:::|::||.||.....|..|.:.         |:....|.|:
Zfish   482 SHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYVKLGPELVPRFFQYQVSRSTR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpV	NP_001259272.1	PTZ00239	3..303	CDD:173488	106/447 (24%)
PpV	NP_001259272.1	MPP_PP2A_PP4_PP6	3..287	CDD:277360	106/447 (24%)
ppef1	XP_021335306.1	IQ	32..54	CDD:197470
		MPP_RdgC	132..532	CDD:277364	96/410 (23%)
		EFh_PEF	567..715	CDD:330173
		EF-hand motif	567..600	CDD:320054
		EF-hand motif	609..649	CDD:320054
		EFh	650..716	CDD:238008
		EF-hand motif	650..683	CDD:320054
		EF-hand motif	690..719	CDD:320054
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900