Protein Alignment PpV and PPP5C

DIOPT Version :10

• Sequence 1: NP_511061.1
• Gene: PpV / 31582
• FlyBaseID: FBgn0003139
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_006238.1
• Gene: PPP5C / 5536
• HGNCID: 9322
• Length: 499
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 126/298 - (42%)
• Similarity: 171/298 - (57%)
• Gaps: 19/298 - (6%)

  Fly     1 MGDVDKWIEDVK----KCKY----LPENELKKLCEMVCDILLEETNILPVSTPVTVCGDIHGQFY 57
            |.::.:|.:|.|    ||.|    ..:..|.||..:| :..|:||.      .:|||||.|||||
Human   191 MKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLV-ETTLKETE------KITVCGDTHGQFY 248

  Fly    58 DLEQLFRTGGQVPHTN-YIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVY 121
            ||..:|...|....|| |||.|||||||.:|:|....|...|..||....||||||||..:.::|
Human   249 DLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIY 313

  Fly   122 GFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCVHGGL-SPEIITLDQIRTIDRNGEIPY 185
            ||..|..:|| .|..::...:||:.|.:|..|:.:||.:|||| |.:.:|||.||.|:||.:.|.
Human   314 GFEGEVKAKY-TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPD 377

  Fly   186 KGAFCDLVWSDPEDMEYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGKL 250
            .|..|||:||||:.......|.||....||.:|||.|:..|||:.|.|:|::..||.:....|:.
Human   378 SGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRC 442

  Fly   251 VTVWSAPNYCYRCGNVAAILSFETAEKR-QTKIFLAVP 287
            |||:||||||.:.||.|:.:..:.::.| |...|.|||
Human   443 VTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PpV	NP_511061.1	MPP_PP2A_PP4_PP6	3..287	CDD:277360	123/294 (42%)
PPP5C	NP_006238.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		NlpI	<19..147	CDD:443815
		TPR 1	28..61
		TPR repeat	28..56	CDD:276809
		TPR repeat	61..91	CDD:276809
		TPR 2	62..95
		TPR 3	96..129
		TPR repeat	96..124	CDD:276809
		MPP_PP5_C	176..491	CDD:277362	126/298 (42%)
		Catalytic	184..499		126/298 (42%)
		Required for autoinhibition. /evidence=ECO:0000250|UniProtKB:P53042	495..499