Protein Alignment PpV and PPP3CC

DIOPT Version :10

• Sequence 1: NP_511061.1
• Gene: PpV / 31582
• FlyBaseID: FBgn0003139
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 115/283 - (40%)
• Similarity: 163/283 - (57%)
• Gaps: 20/283 - (7%)

  Fly    10 DVKKCKYLPENELK-----KLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQV 69
            ||.|...:.|..|:     |:......||.:|..::.|..|:||||||||||:||.:||..||..
Human    40 DVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSP 104

  Fly    70 PHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNA 134
            .:|.|:|:||:|||||:|:|....|.:||..:|..:.|||||||.|.:|..:.|..||..|| :.
Human   105 SNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKY-SE 168

  Fly   135 NGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDP-E 198
            ..:..|.:.||.|.:||:::::.||||||:||||.:||.||.:||..|.|..|..|||:|||| |
Human   169 QVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSE 233

  Fly   199 DM-------EYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGK------L 250
            |.       .|...:.||..:.:.:....:|:..|||..|.|||:..:.|.:.....:      |
Human   234 DYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSL 298

  Fly   251 VTVWSAPNYCYRCGNVAAILSFE 273
            :|::|||||.....|.||:|.:|
Human   299 ITIFSAPNYLDVYNNKAAVLKYE 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PpV	NP_511061.1	MPP_PP2A_PP4_PP6	3..287	CDD:277360	115/283 (41%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	115/283 (41%)
		Catalytic. /evidence=ECO:0000305	52..343		111/271 (41%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521