DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpV and PPP3CA

DIOPT Version :9

Sequence 1:	NP_001259272.1	Gene:	PpV / 31582	FlyBaseID:	FBgn0003139	Length:	303	Species:	Drosophila melanogaster
Sequence 2:	NP_000935.1	Gene:	PPP3CA / 5530	HGNCID:	9314	Length:	521	Species:	Homo sapiens

Alignment Length:	283	Identity:	116/283 - (40%)
Similarity:	163/283 - (57%)	Gaps:	20/283 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DVKKCKYLPENELK-----KLCEMVCDILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQV 69
            |:.|...:.|..|:     ::......||.:|.|:|.:..||||||||||||:||.:||..||..
Human    44 DILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSP 108

  Fly    70 PHTNYIFMGDFVDRGYYSLETFTRLLTLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNA 134
            .:|.|:|:||:|||||:|:|....|..||..||..:.|||||||.|.:|:.:.|..||..|| :.
Human   109 ANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY-SE 172

  Fly   135 NGWKYCCKVFDLLTIAAIIDEEVLCVHGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDP-E 198
            ..:..|...||.|.:||:::::.|||||||||||.|||.||.:||..|.|..|..||::|||| |
Human   173 RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLE 237

  Fly   199 DM-------EYWGQSPRGAGWLFGHNVTKDFMAINNLNLICRAHQLVNEGIKYMFDGK------L 250
            |.       .:...:.||..:.:.:....:|:..|||..|.|||:..:.|.:.....:      |
Human   238 DFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSL 302

  Fly   251 VTVWSAPNYCYRCGNVAAILSFE 273
            :|::|||||.....|.||:|.:|
Human   303 ITIFSAPNYLDVYNNKAAVLKYE 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpV	NP_001259272.1	PTZ00239	3..303	CDD:173488	116/283 (41%)
PpV	NP_001259272.1	MPP_PP2A_PP4_PP6	3..287	CDD:277360	116/283 (41%)
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	116/283 (41%)
		Catalytic. /evidence=ECO:0000305	56..340		113/271 (42%)
		SAPNY motif. /evidence=ECO:0000305\|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042	327..336
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:18384083, ECO:0000269\|PubMed:19404396, ECO:0000269\|PubMed:25144868, ECO:0000269\|Ref.31	392..406
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820