DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and FZO1

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_009738.1	Gene:	FZO1 / 852477	SGDID:	S000000383	Length:	855	Species:	Saccharomyces cerevisiae

Alignment Length:	910	Identity:	178/910 - (19%)
Similarity:	344/910 - (37%)	Gaps:	251/910 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NRTISMVTGQTGPADDDRHASSTDTVDKSG-PGSPLSRFNSS-----LQQSGSTMAANLLPESRL 64
            :|| ::..|:.|..:||...|...:..|:. ..|.||::|.:     |::|.....|.:   .:|
Yeast    53 DRT-TLFDGEEGRREDDLLPSLRSSNSKAHLISSQLSQWNYNNNRVLLKRSILKTQAFM---DQL 113

  Fly    65 YQSNDKSPLQIFVRA---KKKINDIYGEIEEYVHETTTFINALHAEAEIVDKAERELFESYVYKV 126
            .:.|:..|  ||:.|   ::|::.:...|:......|...|..:.|    .||..:||.|.:..|
Yeast   114 QEENNIRP--IFIAANDEREKLHVLQLNIKLDGQYNTKEKNGFNIE----KKALSKLFHSQIVSV 172

  Fly   127 A----AIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYL 187
            .    |:::.:.....||...|..:.|||::.|::|::::||......||.|.::..:.
Yeast   173 TNHLNALKKRVDDVSSKVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNVFSEILEAR------ 231

  Fly   188 MTEGSEE----KLNVV---------------------NIKQLANALCQEKLCESSLVRIFWPRER 227
            ..:|.||    .||:.                     .:|:|.:.:.|..  :.:|::|:...::
Yeast   232 ENDGIEEVHAIPLNIAPTLKEAIDMYSIQNPKTYEIHTLKELPDLVPQNG--KYALLKIYIKDDK 294

  Fly   228 ----CSLLRD---DVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVS 285
                .||||:   |:..:||||:::.:.....:.:.....|:.:.|:|||:.:|.:.|:|....|
Yeast   295 RPASTSLLRNGTVDISLIDSPGLNMDSLQTAEVMSRQEEIDLVIFVVNAENQLTLSAKEFISLAS 359

  Fly   286 QKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERCIDFLTKELKVSNEKEAAERVFFVSA 350
            ::  |..:|.:..::|...::..|:|..|.::             ::|.....|.||:.|.|||.
Yeast   360 RE--KKLMFFVVKKFDKIRDKQRCKELILKQI-------------RDLSPETYKRAADFVHFVSK 409

  Fly   351 RETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEECISQSAVKTKFQQHSSRGKSVSGD 415
            .............|..|                 .:||.::           ..:||  .....|
Yeast   410 NGDELPHYHNENDNEDH-----------------GDRKPDD-----------DPYSS--SDPDPD 444

  Fly   416 MKSMLDNIYERITIFRNL------KQDQKNLLTERIQGTETQMMQVTREMKMKIHNMVEEVEEKV 474
            ..|:.|::...:...|:|      |.....||::.|..:::.|...:.| ::||:..:|.:..::
Yeast   445 FDSLEDSLRNFVLKKRSLSKLLPAKTYLSKLLSDIIMISKSNMKMYSEE-EIKINEQLETLRPEI 508

  Fly   475 SKA------LNEEIWRLG-------------VLIDEFNMPFHPERLVLNIYKKELNAHVESGLGS 520
            ..|      |...:.::.             .|::..::|.|.       |.|      ..|||.
Yeast   509 LSARAKCNDLTTSVDQMAEQTITMTYNNTKEALLNALDVPLHE-------YPK------YQGLGQ 560

  Fly   521 NLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLA-TSTKMVVRTQPFEMLYSLNCQNLCADFQ 584
                     :...:.|.:..:.:::...:.:.:|.| ..|.::|:     .:|.:....|..||
Yeast   561 ---------IYDFIFSTEAFIANQIDESIGSSELFAKQKTDLLVK-----KIYEIGKNELGDDF- 610

  Fly   585 EDLEFKFSWGIAAMIQR-FTGKVRERSKKGQPALVNRQSSIGHSVS---TPT----------TTP 635
                         |.:| |..::..|.:|   .|:.::..:..|::   .||          ..|
Yeast   611 -------------MCERVFRSELMFRKRK---HLIGKRLKVSLSITDLFAPTWKGFLSYLSWQKP 659

  Fly   636 VEATPVCLLPAPVVAGITPE-QLSLISRFAVSS-------------------------IGSQGTV 674
            |.|      |.|.:.|.|.| |:.|:....:.:                         :||...|
Yeast   660 VTA------PLPDIEGQTNEGQIGLMKYLGLKNYPLTQYWSRPSLLFTSKIPTLTLYFLGSTKVV 718

  Fly   675 GGLVVAGVMLKTIGWRVL-------VGVGALYGCIYLYERLSWTNSAKERTFKSQYVRHATKKLK 732
            |.:::.|:.|.:  |..|       :.||:|.|..||...|.   .|.......:|.|    ||:
Yeast   719 GNIILNGIKLSS--WSSLKKLSVPVIVVGSLLGLTYLIHDLP---RALPMNLSIKYKR----KLQ 774

  Fly   733 MI--VDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLDSQLNILEANQKQLKLLRNK 795
            .:  :.|.:...|::|:..|......:.|:.:..........|.|:        |:|:..||..|
Yeast   775 ELDYIHLNAQRTSNEVRDVLRVPTREILRSCEIIMDKKQITKKELE--------NKKESNLLSIK 831

Fly 796 795
Yeast 832 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	20/83 (24%)
		DLP_2	138..393	CDD:206739	59/286 (21%)
		Fzo_mitofusin	652..811	CDD:282633	36/179 (20%)
FZO1	NP_009738.1	CrfC	128..841	CDD:223771	157/829 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344492
Domainoid	1	1.000	41	1.000	Domainoid score	I3231
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	1	1.000	-	-		oto99505
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10465
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2532
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060