DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and FZL

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_171815.3	Gene:	FZL / 839566	AraportID:	AT1G03160	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	810	Identity:	168/810 - (20%)
Similarity:	285/810 - (35%)	Gaps:	252/810 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TMAANLLPESR----LYQSNDKSPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVDK 113
            |...|.|||.:    ..:..||..|.:             |:|:.|         |....||:.|
plant   286 TQNMNELPEKKNSAGFIKLEDKQKLIV-------------EMEKSV---------LRETIEIIHK 328

  Fly   114 AERELFESYVYKVAAIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTN-----C 173
            | ..|.|.....:.|:..:  .:...:...|..::|||:||||:|.::.|..|:..|||     |
plant   329 A-APLMEEVSLLIDAVSRI--DEPFLMVIVGEFNSGKSTVINALLGKRYLKEGVVPTTNEITFLC 390

  Fly   174 FCQVEGSNGGEAYLMTEGSEEKLNVVNIKQLANALCQ-----EKLCESSLVRIFWPRERCSLLRD 233
            :..:|             |||:..           ||     :.:|       :.|   ..:|:
plant   391 YSDLE-------------SEEQQR-----------CQTHPDGQYVC-------YLP---APILK- 420

  Fly   234 DVVFVDSPGVDVSANLDDWIDNHCL-NADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILN 297
            |:..||:||.:|.......:....: .||:.|.||:|:..:|.:|..|.. .:|:..|..:||||
plant   421 DINIVDTPGTNVILQRQQRLTEEFVPRADLLVFVLSADRPLTESEVAFLR-YTQQWKKKFVFILN 484

  Fly   298 NRWDASANEPECQESELAKVKSQHTERCIDFLTKEL-KVSNEKEAAERVFFVSARETLQARIEEA 361
                         :|::.: .::..|..|.|:.:.. |:.|.:...  ::.||||..|:|::..|
plant   485 -------------KSDIYR-DARELEEAISFVKENTRKLLNTENVI--LYPVSARSALEAKLSTA 533

  Fly   362 K---------GNPPHMGAIAEGFQIRYFEFQDFERKFEECISQSAVKTKFQQHSSRGKSVSGDMK 417
            .         .:|        |...|...|.:.| ||......|:..|..
plant   534 SLVGRDDLEIADP--------GSNWRVQSFNELE-KFLYSFLDSSTATGM--------------- 574

  Fly   418 SMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQ----VTREMKMKIHNMVEEVEEKVSKAL 478
                   |||    .||.:....:.||:..:...:::    ..||.......::...:|...|..
plant   575 -------ERI----RLKLETPMAIAERLLSSVEALVRQDCLAAREDLASADKIISRTKEYALKME 628

  Fly   479 NEEI-WRLGV--LIDEFNMPFHPERLVLNIYKKELNAHVESGLGSNLR-ARLSMALA---MNVES 536
            .|.| ||...  |||...:                  .|...:|:.|| :.|.:|::   ...:|
plant   629 YESISWRRQALSLIDNARL------------------QVVDLIGTTLRLSSLDLAISYVFKGEKS 675

  Fly   537 AQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCADFQEDLEFKFSWGIAAMIQR 601
            |....|.::..     ::||.:.              .|.:.|...:.|.|:...:...:..::.
plant   676 ASVAATSKVQG-----EILAPAL--------------TNAKELLGKYAEWLQSNTAREGSLSLKS 721

  Fly   602 FTGKVRERSKKGQPALVNRQSSIG----------HSVSTPTTTPVEATPVCLLPAPVVAGITPEQ 656
            |..|        .|..||.::.:|          ..||..|...:.            ||.|.::
plant   722 FENK--------WPTYVNSKTQLGIDTYDLLQKTDKVSLKTIQNLS------------AGTTSKR 766

  Fly   657 LSLISR--FAVSSIGSQGTVGGLVVAG--------VMLKTIGWRVLVGVGALYGCIYLYERLSWT 711
            |....|  |.|       |||||..||        |:..|:...:.:|:.:..|.:.:
plant   767 LEQDIREVFFV-------TVGGLGAAGLSASLLTSVLPTTLEDLLALGLCSAGGYVAI------- 817

  Fly   712 NSAKERTFKSQYVRHA-TKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELK-T 774
                   ....|.|.| ..|:..:.|..:......:|::||...:.|...|:.......:|.: .
plant   818 -------ANFPYRRQAIIGKVNKVADALAQQLEDAMQKDLSDATSNLVNFVNIVAKPYREEAQLR 875

  Fly   775 LDSQLNILEANQKQLKLLRNKANYIQNELD 804
            ||..|.|    ||:|..:|:|...:|.::|
plant   876 LDRLLGI----QKELSDIRSKLQLLQVDID 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	21/79 (27%)
		DLP_2	138..393	CDD:206739	65/275 (24%)
		Fzo_mitofusin	652..811	CDD:282633	38/165 (23%)
FZL	NP_171815.3	TIM	96..>212	CDD:389746
FZL	NP_171815.3	DLP_2	350..566	CDD:206739	65/276 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	42	1.000	Domainoid score	I4784
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000