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Protein Alignment Marf and Mfn2

DIOPT Version :10

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_570964.4	Gene:	Mfn2 / 64476	RGDID:	628843	Length:	757	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	357/752 - (47%)
Similarity:	507/752 - (67%)	Gaps:	32/752 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEI--VDKAEREL-FESYVYKVAAIREV 132
            |||:.||.||||||.|:.::..|:.|:..|:...|...|:  |...|:.| .:.|:.||..|.||
  Rat    27 SPLKHFVTAKKKINGIFEQLGAYIQESAGFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEV 91

  Fly   133 LQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKLN 197
            |.|.|||||||||||||||:||||||.:|:||||||||||||.:|.|::|.||:|:|||||||.:
  Rat    92 LARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKS 156

  Fly   198 VVNIKQLANALCQ-EKLCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNAD 261
            |..:.|||:||.| |:|...|||.:.||..:|.||:||:|.:||||:||:..||.|||..||:||
  Rat   157 VKTVNQLAHALHQDEQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDAD 221

  Fly   262 VFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERCI 326
            |||||.|:|||:.:.||||||.||::||:||||||||||||||:|||..|    :|:.||.|||.
  Rat   222 VFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYME----EVRRQHMERCT 282

  Fly   327 DFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEE 391
            .||..||.|.:..:|.:|:|||||:|.|.||:::|:|.|...||:|||||:|.||||:|||:|||
  Rat   283 SFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEE 347

  Fly   392 CISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIY----ERITIFRNLKQDQKNLLTERIQGTETQM 452
            |||||||||||:||:.|.|.::..::.::|:::    |:......::::::    :|::..:.|:
  Rat   348 CISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQ----DRLRFIDKQL 408

  Fly   453 MQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESG 517
            ..:.::.|::|..|.||||.:||.|:.|||.||.||:||:.|.|||..:||.:||.||:.|:|.|
  Rat   409 ELLAQDYKLRIKQMTEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEG 473

  Fly   518 LGSNLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCAD 582
            ||.|:..|.|.|:|.::::.|.:|.|.:..|:|..  :.....|:|..|.|.:.|.|||..||||
  Rat   474 LGRNMSDRCSTAIASSLQTMQQDMIDGLKPLLPVS--VRNQIDMLVPRQCFSLSYDLNCDKLCAD 536

  Fly   583 FQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTTTPVEATPVCLLPAP 647
            ||||:||.||.|...::.||.|     .|..:.||:.....:        ..|:..||......|
  Rat   537 FQEDIEFHFSLGWTMLVNRFLG-----PKNSRRALLGYNDQV--------QRPLPLTPANPSMPP 588

  Fly   648 VVAG-ITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALYGCIYLYERLSWT 711
            :..| :|.|:|.:.....::|:.|:.::|.|||.||:.|.:|||::.....|||.:|:||||:||
  Rat   589 LPQGSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWT 653

  Fly   712 NSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLD 776
            ..||||.||.|:|.:|::||::|:..|.:|||||||||||.|||.||:.||....::..|:..::
  Rat   654 TRAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMN 718

  Fly   777 SQLNILEANQKQLKLLRNKANYIQNELDIFEHNYISP 813
            .::..|::.|.:.|||||||.::.:||::|.|.|:.|
  Rat   719 KKVEALDSLQSKAKLLRNKAGWLDSELNMFIHQYLQP 755

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.