DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and mfn2

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001121726.1	Gene:	mfn2 / 567448	ZFINID:	ZDB-GENE-081105-44	Length:	757	Species:	Danio rerio

Alignment Length:	764	Identity:	364/764 - (47%)
Similarity:	520/764 - (68%)	Gaps:	40/764 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ESRLYQSNDKSPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVD-KAERELFE--SY 122
            :.||....:.|||:.||.||||||.|:.::..|:.|::.|:...::..|:.. ..|.::.|  .|
Zfish    17 DKRLMAEVNASPLKHFVTAKKKINGIFEQLGAYIKESSAFLEETYSNEELDPVTTEEQVAEVRGY 81

  Fly   123 VYKVAAIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYL 187
            :.|||.|.|||.|.||||.|||||||||||||||||.:|:||||||||||||.:|||::|.|::|
Zfish    82 LSKVAGIGEVLSRRHMKVVFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRVEGTDGNESFL 146

  Fly   188 MTEGSEEKLNVVNIKQLANALCQ-EKLCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDD 251
            :||||:|:.:|..:.|||:||.| |.|...|||.:.||:.:|:|||||:|.|||||:||:..||.
Zfish   147 LTEGSDERKSVKTVNQLAHALHQDEDLDAGSLVCVMWPKAKCALLRDDLVLVDSPGIDVTTELDS 211

  Fly   252 WIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAK 316
            |||..||:|||||||.|:|||:.:.||.|||.|:::||.||||||||||||||||||..|    :
Zfish   212 WIDKFCLDADVFVLVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWDASANEPEYME----E 272

  Fly   317 VKSQHTERCIDFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFE 381
            |:.||.:||..||..||:|.:...|.:|:|||||:|.||||:::|:|.|...||:|||||.|.||
Zfish   273 VRRQHMDRCTSFLVDELRVVDRSHAGDRIFFVSAKEVLQARVQKAQGMPEAGGALAEGFQARMFE 337

  Fly   382 FQDFERKFEECISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIY-----ERITIFRNLKQDQKNLL 441
            ||:|||:||||||||||||||:||::|.|.:|..::.::|:::     :||... .:|::::
Zfish   338 FQNFERRFEECISQSAVKTKFEQHTTRAKQISEALRLIMDSVHIAAQEQRIHCL-EMKEERE--- 398

  Fly   442 TERIQGTETQMMQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIY 506
             :|::..:.|:..:|.:.|.||..:.||||::||.|:.|||.||.||:|:|:|.|||..:||.:|
Zfish   399 -DRLEFIDKQLDLLTLDCKSKIKKITEEVEKQVSNAMAEEIRRLAVLVDDFHMDFHPSPVVLKVY 462

  Fly   507 KKELNAHVESGLGSNLRARLSMALAMNVESAQTEMTDRMHALVP---NEQLLATSTKMVVRTQPF 568
            |.||:.|:|.|||.|:..|.|.|:.:.:::.||:|.|.:..|:|   .||:    .|||.| |.|
Zfish   463 KNELHRHIEEGLGRNMSERCSSAITVALQTTQTDMIDGLKPLLPITIREQV----DKMVPR-QCF 522

  Fly   569 EMLYSLNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTT 633
            .:.|.|||..||:|||||:.|.||.|...::.||.|...           .|::.:|::...|.:
Zfish   523 ALSYDLNCDKLCSDFQEDIGFHFSLGWTMLVNRFLGPKN-----------TRRALMGYNDQVPRS 576

  Fly   634 TPVEATPVCLLPAPVVAG-ITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGA 697
            ..:  |||.....|...| :|.|:|.:.....::|:.|:.::|.:||.||:.|.:|||::.....
Zfish   577 LAI--TPVSTSMPPFPQGSMTQEELMVSMVTGLASLTSRTSMGIIVVGGVIWKAVGWRLIALSVG 639

  Fly   698 LYGCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVD 762
            |||.:|:||||:||..|||||||.|:|.:|::||::||..|.:||||||||||:|||::||:.||
Zfish   640 LYGLLYVYERLTWTTRAKERTFKRQFVDYASEKLQLIVSYTGSNCSHQVQQELASTFSQLCQQVD 704

  Fly   763 TATTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHNYI 811
            .....:.||:..|:|::..|:..|.:.|||||||.::.:||::|...|:
Zfish   705 VTRQQLEDEIGDLNSKIEQLDTLQSKAKLLRNKAGWLDSELNMFIQQYL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	45/82 (55%)
		DLP_2	138..393	CDD:206739	160/255 (63%)
		Fzo_mitofusin	652..811	CDD:282633	72/158 (46%)
mfn2	NP_001121726.1	DLP_2	97..349	CDD:206739	160/255 (63%)
mfn2	NP_001121726.1	Fzo_mitofusin	594..754	CDD:282633	73/160 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585314
Domainoid	1	1.000	286	1.000	Domainoid score	I1565
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8915
Inparanoid	1	1.050	690	1.000	Inparanoid score	I673
OMA	1	1.010	-	-		QHG52369
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	1	1.000	-	-		otm26150
orthoMCL	1	0.900	-	-		OOG6_103484
Panther	1	1.100	-	-	O	PTHR10465
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1894
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910