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Protein Alignment Marf and MFN1

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_284941.2	Gene:	MFN1 / 55669	HGNCID:	18262	Length:	741	Species:	Homo sapiens

Alignment Length:	762	Identity:	357/762 - (46%)
Similarity:	485/762 - (63%)	Gaps:	54/762 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVDK--AERELFE--SYVYKVAAIRE 131
            |||:.||.|||.|..|:.::.|:|.|.:.|:.|.:...|: |:  .|.:|.|  .|..|::.|.|
Human     6 SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPEL-DRIATEDDLVEMQGYKDKLSIIGE 69

  Fly   132 VLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKL 196
            ||.|.|||||||||||:||||||||||.:|:|||||||.||||..|||::|.:||||||||:||.
Human    70 VLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGSDEKK 134

  Fly   197 NVVNIKQLANALCQEK-LCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNA 260
            :|..:.|||:||..:| |....|||:|||:.:|:|||||:|.|||||.||:..||.|||..||:|
Human   135 SVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDA 199

  Fly   261 DVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERC 325
            ||||||.|:|||:...||.|||.|:::|||||||||||||||||:|||..|.    |:.||.|||
Human   200 DVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMED----VRRQHMERC 260

  Fly   326 IDFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFE 390
            :.||.:||||.|..||..|:|||||:|.|.||.::|:|.|....|:||||..|..|||:||:.||
Human   261 LHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFE 325

  Fly   391 ECISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQV 455
            ||||||||||||:||:.|.|.:...:|:::|::.......|:...:::....:|:.....||..:
Human   326 ECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLL 390

  Fly   456 TREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESGLGS 520
            |.::|.||..:.|||..|||.|:.:||.||.||:|||...|||...||.|||.|||.|:|.|:|.
Human   391 TLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGR 455

  Fly   521 NLRARLSMALAMNVESAQTE------------MTDRMHALVPNEQLLATSTKMVVRTQPFEMLYS 573
            ||..|.:..:...|...|.|            :.|::|.|:|              .:.|::.|:
Human   456 NLADRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLIP--------------CKKFDLSYN 506

  Fly   574 LNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSI----GHSVSTPTTT 634
            ||...||:|||||:.|:||.|.::::.||.|     .:..|..|:.....|    ....||||..
Human   507 LNYHKLCSDFQEDIVFRFSLGWSSLVHRFLG-----PRNAQRVLLGLSEPIFQLPRSLASTPTAP 566

  Fly   635 PVEATPVCLLPAPVVAGITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALY 699
            ...|||         ...:.|:|.:.....::|:.|:.::|.::|.||:.|||||::|.....:|
Human   567 TTPATP---------DNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMY 622

  Fly   700 GCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTA 764
            |.:|||||||||..||||.||.|:|.:||:||:|||..|||||||||:|::::||||||:.||..
Human   623 GALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDIT 687

  Fly   765 TTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHNYI 811
            ...:.:|:..|..:::.||..|...|||||||..::|||:.|...::
Human   688 QKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFL 734

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.