DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and mfn2

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001016514.1	Gene:	mfn2 / 549268	XenbaseID:	XB-GENE-480103	Length:	756	Species:	Xenopus tropicalis

Alignment Length:	746	Identity:	365/746 - (48%)
Similarity:	509/746 - (68%)	Gaps:	24/746 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVDKA-ERELFE--SYVYKVAAIREV 132
            |||:.||.||||||.|:.::..|..|:..|:...:.:||:...| |.::||  .|:..||.|.||
Frog    27 SPLKHFVTAKKKINGIFDQLAAYTQESYNFLEETYKDAELDPVASEEQVFEVKGYLTNVAGISEV 91

  Fly   133 LQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKLN 197
            |.|.||||||||||||||||||||||.:|:||||||||||||.:|||::|.|:||:|.|||||.:
Frog    92 LARRHMKVAFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRVEGTDGNESYLLTGGSEEKRS 156

  Fly   198 VVNIKQLANALCQEKLCES-SLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNAD 261
            |..:.|||:||.|:.|.:| |||.:.||..:|.||:||:|.:||||:||:..||.|||..||:||
Frog   157 VKTVNQLAHALHQDDLLDSGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDAD 221

  Fly   262 VFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERCI 326
            |||||.|:|||:.:.||||||.|:::||:||||||||||||||:|||..|    :|:.||.|||.
Frog   222 VFVLVANSESTLMQTEKQFFHKVNERLSRPNIFILNNRWDASASEPEYME----EVRRQHMERCT 282

  Fly   327 DFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEE 391
            .||..||.|.:..:|.:|:|||||:|.|.|||::|:|.|...||:|||||.|.||||:|||:|||
Frog   283 SFLVDELGVLDRTQAGDRIFFVSAKEVLNARIQKAQGMPEGGGALAEGFQARMFEFQNFERRFEE 347

  Fly   392 CISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQVT 456
            |||||||||||:||:.|.|.::..::.::::::......|.|..:::....:|::..|.|:..:|
Frog   348 CISQSAVKTKFEQHTKRAKQIAEVLRQIMESVHVAAQEQRCLCLEKREEFRDRLEFIEKQLELLT 412

  Fly   457 REMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESGLGSN 521
            .:.|.||..:.:|||.:||.|:.|||.||.:|:|||.:.|||..:||.:||.||:.|:|.|||.|
Frog   413 EDYKFKIKQITDEVERQVSNAMAEEIRRLSILVDEFQLDFHPSSVVLKVYKNELHRHIEEGLGRN 477

  Fly   522 LRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCADFQED 586
            |..|.|..:::::::.|.||.:.|..|:|  ....|.|.::|..|.|.:.|.|:|..||||||||
Frog   478 LSDRCSSVISVSLQTTQQEMIEGMMPLLP--PTARTQTDLLVPRQCFNLSYDLSCDKLCADFQED 540

  Fly   587 LEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTTTPVEATPVCLLPAPVVAG 651
            :||.||.|...::.||.|     .|.|:.||      :.:|...|...|:  |||.....|:..|
Frog   541 VEFHFSLGWTMLVNRFLG-----PKNGRRAL------MAYSDQVPRAMPL--TPVNPSMPPMPQG 592

  Fly   652 -ITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALYGCIYLYERLSWTNSAK 715
             :|.|:|.:.....::|:.|:.::|.|||.||:.|.:|||::.....|||.:|:||||:|||.||
Frog   593 SMTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTNKAK 657

  Fly   716 ERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLDSQLN 780
            ||.||.|:|.:|.:||::||..|.:|||||||||||.|||.||:.||....::..::..|:.::.
Frog   658 ERAFKRQFVEYAAEKLQLIVSYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQDIDVLNKKIE 722

  Fly   781 ILEANQKQLKLLRNKANYIQNELDIFEHNYI 811
            ||:..|.:.|||||||.::.:||::|.|.|:
Frog   723 ILDGLQSKAKLLRNKAGWLDSELNMFTHQYL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	48/82 (59%)
		DLP_2	138..393	CDD:206739	162/255 (64%)
		Fzo_mitofusin	652..811	CDD:282633	73/158 (46%)
mfn2	NP_001016514.1	DLP_2	97..349	CDD:206739	162/255 (64%)
mfn2	NP_001016514.1	Fzo_mitofusin	594..754	CDD:282633	74/160 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1559
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8915
Inparanoid	1	1.050	705	1.000	Inparanoid score	I647
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	1	1.000	-	-		otm48376
Panther	1	1.100	-	-	O	PTHR10465
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1894
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160