DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and mfn1

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001016189.1	Gene:	mfn1 / 548943	XenbaseID:	XB-GENE-998114	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	765	Identity:	353/765 - (46%)
Similarity:	496/765 - (64%)	Gaps:	56/765 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVD----------KAERELFESYVYK 125
            |||:.||.|||.|..|:.::.|||.|..||:.......|:.:          ||.:.       |
Frog     7 SPLKHFVLAKKSITSIFDQLVEYVSEGVTFVEETFQNPELKNVSTEDDVNKVKASKT-------K 64

  Fly   126 VAAIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTE 190
            :|.|.|||.|.:||||||||||:|||:|||:||.:|:||||||||||||..|||:.|.:||||||
Frog    65 LAGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGTEGDKAYLMTE 129

  Fly   191 GSEEKLNVVNIKQLANALCQEK-LCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWID 254
            |||||.:|..:.|||:||..:| |....||.:|||:.:|:|||||:|.|||||.||:..||.|||
Frog   130 GSEEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWID 194

  Fly   255 NHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKS 319
            ..||:|||||||.|:|||:...||.||:.|::||||||||||||||||||:|||..|.    |:.
Frog   195 KFCLDADVFVLVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWDASASEPEYMED----VRK 255

  Fly   320 QHTERCIDFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQD 384
            ||.|||..||..||||.:..||.:|:|||||:|.|.||:.:|:|.|....|:||||..|:.|||.
Frog   256 QHMERCQSFLVDELKVVDSLEAQKRIFFVSAKEVLNARMHKAQGMPEAGAALAEGFHTRFLEFQK 320

  Fly   385 FERKFEECISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIYERITIFRNLKQDQKNL--------L 441
            ||:.||||||||||||||:||:...|.::..:|:::|.|        |:|...|.:        .
Frog   321 FEKLFEECISQSAVKTKFEQHTITAKQITDTVKAIMDAI--------NIKAADKRVRCMVERENQ 377

  Fly   442 TERIQGTETQMMQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIY 506
            .:|::..:|||:.:|.|::.:|.::.:||.|:||.|:.:||:.|.:|:|:|:..|||...||.:|
Frog   378 NDRLEYVKTQMLILTEEIEKRILHITKEVNEQVSSAMMDEIYHLSLLVDKFDAEFHPSLSVLKLY 442

  Fly   507 KKELNAHVESGLGSNLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEML 571
            |.|||.|:|:|:|..|..|.|.|:.|:::.||.::.|::..|:|..  :...|.:.:..:.|::.
Frog   443 KNELNLHIENGMGRKLADRCSNAVNMSIQKAQEDIIDKLMPLLPPS--VQDQTTISLPCKKFDLS 505

  Fly   572 YSLNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKG--QPALVNRQSSIGHSVSTPTTT 634
            |::||:.||:|||||:||:||:|:.::..||.|........|  :|..     .|...||||:.|
Frog   506 YNINCEKLCSDFQEDVEFRFSFGLTSLANRFLGCKTSHLLLGFAEPMF-----QIPRPVSTPSAT 565

  Fly   635 PVEATPVCLLPAPVVAGITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALY 699
               ..|| |.|.|.    :.|:|.|.....::|:.|:|::..::|.||:.:|:|||::.|:...|
Frog   566 ---GNPV-LPPQPA----SQEELMLSVMSGLASLTSRGSMSVIIVGGVIWRTVGWRLISGMMLAY 622

  Fly   700 GCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTA 764
            |.:||||||:||..||||.||.|:|.:|.:|||:||..||||||.|||:||.:||.|||:.||..
Frog   623 GGLYLYERLTWTTRAKERAFKKQFVNYAAQKLKLIVSFTSANCSQQVQKELDNTFKRLCQQVDVT 687

  Fly   765 TTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHNYISPQ 814
            ..|:.:.:..|..:::.||..|...|.|||:|:.|:.||..|..::: ||
Frog   688 ERDLAESIDKLSEEIHQLEQIQSNSKALRNRASRIEGELRNFAKSFL-PQ 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	43/89 (48%)
		DLP_2	138..393	CDD:206739	159/255 (62%)
		Fzo_mitofusin	652..811	CDD:282633	70/158 (44%)
mfn1	NP_001016189.1	DLP_2	77..329	CDD:206739	159/255 (62%)
mfn1	NP_001016189.1	Fzo_mitofusin	575..734	CDD:368125	70/162 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1559
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	705	1.000	Inparanoid score	I647
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	1	1.000	-	-		otm48376
Panther	1	1.100	-	-	LDO	PTHR10465
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2532
SonicParanoid	1	1.000	-	-		X1894
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190