DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and fzo1

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_595241.1	Gene:	fzo1 / 2539859	PomBaseID:	SPBC1706.03	Length:	758	Species:	Schizosaccharomyces pombe

Alignment Length:	506	Identity:	100/506 - (19%)
Similarity:	195/506 - (38%)	Gaps:	120/506 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 IYGEIEEYVHETTTFINALHAEAEIVDKAERELFESYVYKVAAIREVLQRDHMKVAFFGRTSNGK 150
            :..::.|..||:...::        ::||.:.||..:        ..::....|:...|..:.||
pombe   119 LISQLGEEAHESLLKVH--------IEKANKHLFSLF--------SRVEDTSSKILITGDLNAGK 167

  Fly   151 SSVINAMLREKILPSGIGHTTNCFCQV---EGSNG---------GEAYLMTEGSEEKLNVVNIKQ 203
            |::.||::.:.|||......|..||:|   |.::|         |..|..|:.|..|  |..|:.
pombe   168 STLCNALVHKDILPEDQQPCTEVFCEVHDAELNDGKDCVHAIPHGLTYSHTDSSTYK--VFPIED 230

  Fly   204 LANALCQEKLCESSLVRIFWPR-ERCSLLRD---DVVFVDSPGVDVSANLDDWIDNHCLNADVFV 264
            |...:.:.:.....:|.:...| ...|||.:   |:..:|:||::..:.....:.......||.|
pombe   231 LKRLVYETENWSMLIVYVNDGRPAHESLLHNGITDIALIDAPGLNTDSMKTTSVFACQEEIDVVV 295

  Fly   265 LVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERCIDFL 329
            .|:|||:..|.:...|....|.:  |.:|||:.|::|...::..|:...|.::   ||
pombe   296 FVVNAENHFTLSATDFLRNASTE--KSHIFIIVNKFDNIRDKERCKRLILEQI---HT------- 348

  Fly   330 TKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEECIS 394
               |......:|.:.|.|||.|........|            :.....:|:.::..|.|   |.
pombe   349 ---LSPGTFADAKDLVHFVSCRVARDPNNRE------------DALYSSFFQMENSLRSF---IL 395

  Fly   395 QSAVKTKFQQHSSRGKSVSGDMKSM-----------LDNIYERIT----IFRNLKQDQ------- 437
            ::..|:|..........:.||:.::           ::::.:|:|    .||.:|.:|
pombe   396 ENRSKSKLAPVRRYLSGLVGDILNICEYNIKLIDFDINHLQQRLTDLSPKFRKVKHEQQFTYQKN 460

  Fly   438 KNLLTERIQG----TETQM-------------------------MQVTREMKMKIHNMVEEVEEK 473
            ::|:...:|.    |.:::                         :.|...|:..:...:.|.|:.
pombe   461 ESLVEATVQSISQHTHSELEDAIDSLGSFASVKYSGFFFAYQYAISVRDAMQQYLEEKLLESEDY 525

  Fly   474 VSKALNEEIWRLGVLI-DEFN---MP-FHPERLVLNIYKKELNAHVESGLG 519
            ..|...|.:..:...: |.|:   :| ||..::.:..::.:|..|....||
pombe   526 ARKRTEEAVLCIQKDVKDNFDSAVLPVFHANQMFIKKHRLQLQKHFRFELG 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	17/79 (22%)
		DLP_2	138..393	CDD:206739	64/270 (24%)
		Fzo_mitofusin	652..811	CDD:282633
fzo1	NP_595241.1	CrfC	95..740	CDD:223771	100/506 (20%)
fzo1	NP_595241.1	P-loop_NTPase	156..394	CDD:304359	64/269 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	42	1.000	Domainoid score	I3669
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1984
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10465
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2532
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.180