DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf and fzo-1

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_495161.1	Gene:	fzo-1 / 173990	WormBaseID:	WBGene00001509	Length:	774	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	281/782 - (35%)
Similarity:	437/782 - (55%)	Gaps:	41/782 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SLQQSGSTMAANL--LPESRLYQSNDKSPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEA 108
            :|..||.:....|  |..||  ::.|..||..|..|||.:.|:|||:::.|.|.......: .|.
Worm    10 TLPASGDSNHRGLHSLKNSR--RAADNEPLLRFREAKKVLGDVYGELKDNVAELEGVYKDI-KEN 71

  Fly   109 EIVDKAERELFESYVYKVAAIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNC 173
            :.|...:||..|:....:..|.:..|||:|||.||||||||||:.|||||.||:||.|:||||.|
Worm    72 DFVSSEQREEIEAIGDSIKTIMDTFQRDNMKVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTTCC 136

  Fly   174 FCQVEGSNGGEAYLMTEGSEEKLNVVNIKQLANALCQEK-----LCESSLVRIFWPRE----RCS 229
            |.|||||.|...:|..:.:.:|:::..:.::.:||..|.     :.:.||:::|.|::    .|.
Worm   137 FLQVEGSEGEVGHLQLDDNPQKIDMKMLGKIGHALSDENSDLPAMGQDSLLKVFHPKKSESGECR 201

  Fly   230 LLRDDVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIF 294
            ||::|||.:||||||:|...|.|||.|||:|||||||.|||||:|:|||.||..|::||||||:|
Worm   202 LLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFVLVSNAESTLTQAEKNFFLRVAKKLSKPNVF 266

  Fly   295 ILNNRWDASANEPECQESELAKVKSQHTERCIDFLTKELKVSNEKEAAERVFFVSARETLQARIE 359
            ||||||||||.|.|    .:..||.||..|...||..||:|.:|:|..:|:||||:||.|::|:
Worm   267 ILNNRWDASAAETE----NIEDVKKQHLTRFRQFLVDELEVCSEREVNDRIFFVSSREVLESRL- 326

  Fly   360 EAKGNPPHMGAIAEGFQIRYFEFQDFERKFEECISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIY 424
            :|:| .......|||...|..|||:|||.||.|||:||:.|||:.|:.|...:.|.|:..|:::.
Worm   327 KARG-LVQKAYQAEGHGTRALEFQNFERHFEHCISRSAIHTKFEAHNRRAHEMIGKMRLNLNSVL 390

  Fly   425 ERITIFRNLKQDQKNLLTERIQGTETQMMQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLI 489
            ......|:..|:..|..|...........|..:..:.:...:..||..|||....|||.||..:|
Worm   391 TSAAEQRSKLQNNLNESTRTFNECRVNFTQFEKAYREQTEQLRAEVHLKVSADFFEEIARLDAII 455

  Fly   490 DEFNMPFHPERLVLNIYKKELNAHVESGLGSNLRARLSMALAMNVESAQTEMTDRMHALV--PNE 552
            |.|..||......:..||::|...|:..|.|:|.||.:..|...:.:.:.:|...:..::  |.:
Worm   456 DRFEQPFDGSSSGMTKYKEDLAIFVDKCLSSDLEARCTGGLMSRIWNLENDMFQYVTKILAEPYQ 520

  Fly   553 QLLATSTKMVVRTQ-PFEMLYSLNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPA 616
            ..|    :.|.|.: ||:....::...|..||.|||||:|::|:.|:|:|.   :..||  |||.
Worm   521 NKL----EEVWRYRAPFKFSICVDVPALVNDFHEDLEFRFTFGLHAIIRRI---IAYRS--GQPV 576

  Fly   617 LVNRQSSIGHSVSTPTTTPVEATPVCLLPAPVVAGITPEQLSLISRFAVSSIG--SQGTVGGLVV 679
                 ::|..::.||.:...::....:..|.  |....|:.:::::..::|..  :.|::|.|||
Worm   577 -----TAINTNLLTPLSLKQQSEKNSVRDAE--ASAASEEQAMMTQMVLTSAAFLANGSLGVLVV 634

  Fly   680 AGVMLKTIGWRVLVGVGALYGCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSH 744
            .|::.|.:||||:...||.|..:|.:||:.|.:.|||:..|.|:..|...:::.:....:.:|..
Worm   635 GGIVYKAVGWRVIAVGGAAYAGLYAWERMRWNSGAKEQHLKEQFRSHLAARMQQVSTAHTHHCET 699

  Fly   745 QVQQELSSTFARLCRTVDTATTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHN 809
            |..:|:...|..|..||.....:|.::|....:|::.:::..:.|..::.||.::...|:.|..:
Worm   700 QAIREMDQVFDGLKATVGGVHREMKNDLDVQKTQIDAVDSTIRTLGTIKGKAVFLLRNLEQFASS 764

  Fly   810 YI 811
            |:
Worm   765 YL 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	P-loop_NTPase	<92..172	CDD:304359	37/79 (47%)
		DLP_2	138..393	CDD:206739	137/263 (52%)
		Fzo_mitofusin	652..811	CDD:282633	41/160 (26%)
fzo-1	NP_495161.1	DLP_2	101..359	CDD:206739	137/263 (52%)
fzo-1	NP_495161.1	Fzo_mitofusin	609..767	CDD:282633	41/158 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I2017
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8915
Inparanoid	1	1.050	456	1.000	Inparanoid score	I887
Isobase	1	0.950	-	0	Normalized mean entropy	S3943
OMA	1	1.010	-	-		QHG52369
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	1	1.000	-	-		oto20668
orthoMCL	1	0.900	-	-		OOG6_103484
Panther	1	1.100	-	-	LDO	PTHR10465
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2532
SonicParanoid	1	1.000	-	-		X1894
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.960