Protein Alignment Marf and Dnm3

DIOPT Version :10

• Sequence 1: NP_572320.2
• Gene: Marf / 31581
• FlyBaseID: FBgn0029870
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_612547.1
• Gene: Dnm3 / 171574
• RGDID: 727949
• Length: 869
• Species: Rattus norvegicus
• Alignment Length: 782
• Identity: 139/782 - (17%)
• Similarity: 255/782 - (32%)
• Gaps: 276/782 - (35%)

  Fly   139 KVAFFGRTSNGKSSVINAMLREKILPSGIGHTT-------------------NC-------FCQV 177
            ::|..|..|.|||||:...:....||.|.|..|                   :|       |.:|
  Rat    33 QIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEV 97

  Fly   178 EGSNGGEAYLMTEGSEEKLNVVNIKQLANALCQEKLCESSLVRIFWPRERCSLLRDDVVFVDSPG 242
            ......|...:| |..:.::.|.|.                :|::.|...      ::..:|.||
  Rat    98 RHEIEAETDRVT-GMNKGISSVPIN----------------LRVYSPHVL------NLTLIDLPG 139

  Fly   243 V----------DVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKP------ 291
            :          |:...:.|.|.......:..:|      .:|.|.....::.:.||:|.
  Rat   140 ITKVPVGDQPPDIEYQIRDMIMQFITRENCLIL------AVTPANTDLANSDALKLAKEVDPQGL 198

  Fly   292 ---NIFILNNRWDASANEPECQESELAKVKS------QHTERCIDFLTKELKVSNEKEAAERVFF 347
               .:....:..|...:..:..|::|..::.      ..:::.||. .|::|.:   ..|||.||
  Rat   199 RTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDG-KKDIKAA---MLAERKFF 259

  Fly   348 VSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEECISQSAVKTKFQQH------S 406
            :|  ......|.:..|. ||:                          |..:..:...|      :
  Rat   260 LS--HPAYRHIADRMGT-PHL--------------------------QKVLNQQLTNHIRDTLPN 295

  Fly   407 SRGKSVSGDMKSMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQVTREMKMKIHNMVEEVE 471
            .|.|     ::..|.:|...:..|:|.|.:.....|:.:    .||:|          ....:.|
  Rat   296 FRNK-----LQGQLLSIEHEVEAFKNFKPEDPTRKTKAL----LQMVQ----------QFAVDFE 341

  Fly   472 EKVSKALNEEIWRLGVLID--------EFNMPFHPERLVLNIYKKELNAHVESGLGSNLRARLSM 528
            :::..:        |..:|        :.|..|| ||....|.|.|.|.       ..||..:|.
  Rat   342 KRIEGS--------GDQVDTLELSGGAKINRIFH-ERFPFEIVKMEFNE-------KELRREISY 390

  Fly   529 ALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQ-PF---------EMLYSL-NCQNLCAD 582
            |: .|:...:|.:      ..|:....|...|.:|:.: |.         |::.:: .|....|:
  Rat   391 AI-KNIHGIRTGL------FTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLAN 448

  Fly   583 FQ---EDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALV------------NRQSSIGHSVSTPT 632
            |.   |:.|           :.....:|||..|.:..::            |.:..||.:.:...
  Rat   449 FPRLCEETE-----------RIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQR 502

  Fly   633 TTPVEATPVCLLPAPVVAGITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGA 697
            ::.|...                          |:||:|||  .|..:..::...||..:..:|.
  Rat   503 SSQVHKK--------------------------STIGNQGT--NLPPSRQIVIRKGWLTVSNIGI 539

  Fly   698 L------YGCIYLYERLSW--TNSAKERTF-------------------KSQYVRHATKKLKMIV 735
            :      |..:...|.|||  .:..||:.:                   |..:....|::..:..
  Rat   540 MKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYK 604

  Fly   736 DLTSANCSHQVQQELSSTFARLCRT---VDTATTDMNDELK-----TLDSQLNILEANQKQLKLL 792
            |..|...:...|:::.|..|.|.|.   .|.:.|: |||..     ::|.||      ::|::.:
  Rat   605 DYRSLELACDSQEDVDSWKASLLRAGVYPDKSFTE-NDENGQAENFSMDPQL------ERQVETI 662

  Fly   793 RN 794
            ||
  Rat   663 RN 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marf	NP_572320.2	DLP_2	138..393	CDD:206739	52/304 (17%)
		Fzo_mitofusin	654..811	CDD:461432	37/176 (21%)
Dnm3	NP_612547.1	DYNc	6..245	CDD:197491	40/241 (17%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		3/6 (50%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		1/2 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		0/2 (0%)
		Dynamin_M	215..502	CDD:460033	65/372 (17%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		0/2 (0%)
		PH_dynamin	526..635	CDD:269958	19/108 (18%)
		GED	655..745	CDD:460495	4/16 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..869
		MISS	<753..841	CDD:318115