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Protein Alignment Marf and Mfn2

DIOPT Version :9

Sequence 1:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001272849.1	Gene:	Mfn2 / 170731	MGIID:	2442230	Length:	757	Species:	Mus musculus

Alignment Length:	751	Identity:	354/751 - (47%)
Similarity:	509/751 - (67%)	Gaps:	30/751 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEI--VDKAEREL-FESYVYKVAAIREV 132
            |||:.||.||||||.|:.::..|:.|:.:|:...|...|:  |...|:.| .:.|:.||..|.||
Mouse    27 SPLKHFVTAKKKINGIFEQLGAYIQESASFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEV 91

  Fly   133 LQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKLN 197
            |.|.|||||||||||||||:||||||.:|:||||||||||||.:|.|::|.||:|:|||||||.:
Mouse    92 LARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKS 156

  Fly   198 VVNIKQLANALCQ-EKLCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNAD 261
            |..:.|||:||.| |:|...|:|.:.||..:|.||:||:|.:||||:||:..||.|||..||:||
Mouse   157 VKTVNQLAHALHQDEQLHAGSMVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDAD 221

  Fly   262 VFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERCI 326
            |||||.|:|||:.:.||||||.||::||:||||||||||||||:|||..|    :|:.||.|||.
Mouse   222 VFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYME----EVRRQHMERCT 282

  Fly   327 DFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEE 391
            .||..||.|.:..:|.:|:|||||:|.|.||:::|:|.|...||:|||||:|.||||:|||:|||
Mouse   283 SFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERQFEE 347

  Fly   392 CISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIY----ERITIFRNLKQDQKNLLTERIQGTETQM 452
            |||||||||||:||:.|.|.::..::.::|:::    |:......::::::    :|::..:.|:
Mouse   348 CISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQ----DRLRFIDKQL 408

  Fly   453 MQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESG 517
            ..:.::.|::|..:.||||.:||.|:.|||.||.||:||:.|.|||..:||.:||.||:.|:|.|
Mouse   409 ELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEG 473

  Fly   518 LGSNLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCAD 582
            ||.||..|.|.|:|.::::.|.:|.|.:..|:|..  :.....|:|..|.|.:.|.|||..||||
Mouse   474 LGRNLSDRCSTAIASSLQTMQQDMIDGLKPLLPVS--MRNQIDMLVPRQCFSLSYDLNCDKLCAD 536

  Fly   583 FQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTTTPVEATPVCLLPAP 647
            ||||:||.||.|...::.||.|...           :|::.:|:|.......|:......:.|.|
Mouse   537 FQEDIEFHFSLGWTMLVNRFLGPKN-----------SRRALLGYSDQVQRPLPLTPANPSMPPLP 590

  Fly   648 VVAGITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALYGCIYLYERLSWTN 712
             .:.:|.|:|.:.....::|:.|:.::|.|||.||:.|.:|||::.....|||.:|:||||:||.
Mouse   591 -QSSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTT 654

  Fly   713 SAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLDS 777
            .||||.||.|:|.:|::||::|:..|.:|||||||||||.|||.||:.||....::..|:..::.
Mouse   655 KAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNK 719

  Fly   778 QLNILEANQKQLKLLRNKANYIQNELDIFEHNYISP 813
            ::..|::.|.:.|||||||.::.:||::|.|.|:.|
Mouse   720 KVEALDSLQSRAKLLRNKAGWLDSELNMFTHQYLQP 755

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.