DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kdn and cs

DIOPT Version :9

Sequence 1:	NP_727091.1	Gene:	kdn / 31579	FlyBaseID:	FBgn0261955	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_955892.1	Gene:	cs / 322339	ZFINID:	ZDB-GENE-030131-1058	Length:	468	Species:	Danio rerio

Alignment Length:	435	Identity:	323/435 - (74%)
Similarity:	372/435 - (85%)	Gaps:	0/435 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 AADGKSLRDVLAAKVPQEQERVKNFRKQHGATKMGETTIDMMYGGMRGIKALVTETSVLDADEGI 150
            |:...:|:|||:..||:||.|:|||::|:|.|.:|:.|:||:||||||:|.||.||||||.||||
Zfish    29 ASASTNLKDVLSDLVPKEQSRIKNFKQQYGKTSIGQITVDMVYGGMRGVKGLVYETSVLDPDEGI 93

  Fly   151 RFRGLSIPECQKVLPAADGGTEPLPEGLFWLLLTGEVPTKSQVQQLSREWAERAALPQHVVTMLN 215
            ||||.||||||::||.|.||.|||||||||||:||:|||:.||..||:|||:|||||.||||||:
Zfish    94 RFRGYSIPECQQLLPKAPGGEEPLPEGLFWLLVTGQVPTEEQVSWLSKEWAKRAALPSHVVTMLD 158

  Fly   216 NMPTTLHPMSQFAAAVTALNHDSKFAKAYSDGVHKSKYWEYVYEDSMDLIAKLPVVAATIYCNTY 280
            |.||.|||||||:||:||||.:|.||:|||:||:|:||||:|||||||||||||.|||.||.|.|
Zfish   159 NFPTNLHPMSQFSAAITALNSESSFARAYSEGVNKAKYWEFVYEDSMDLIAKLPCVAAKIYRNLY 223

  Fly   281 RGGKGSRSIDSSLDWSANFVKMLGYDNAPFTELMRLYLTIHSDHEGGNVSAHTVHLVGSALSDPY 345
            |.|....:|||:||||.||..||||....||||||||||||||||||||||||.|||||||||||
Zfish   224 REGSSIGAIDSNLDWSHNFTNMLGYTEPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPY 288

  Fly   346 LSFAAGLNGLAGPLHGLANQEVLVWLRKLQKEAGNNPSEEQLKEYIWKTLKSGQVVPGYGHAVLR 410
            |||:|.:|||||||||||||||||||..||||.|...|:|::::|||.|||||:|||||||||||
Zfish   289 LSFSAAMNGLAGPLHGLANQEVLVWLTALQKELGGEVSDEKMRDYIWNTLKSGRVVPGYGHAVLR 353

  Fly   411 KTDPRYTCQREFALKHLPEDETFQLVSKIYKVVPPILTETGKVKNPWPNVDAHSGVLLQYYGMKE 475
            ||||||||||||||||||.|..|:||:::||:||.:|.|.||.||||||||||||||||||||.|
Zfish   354 KTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTE 418

  Fly   476 MNYYTVLFGVSRALGVLASLVWDRALGLPIERPKSFSTDLLVKMV 520
            ||||||||||||||||||.|||.||||.|:|||||.|||.|:.:|
Zfish   419 MNYYTVLFGVSRALGVLAQLVWSRALGFPLERPKSMSTDGLMALV 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kdn	NP_727091.1	PLN02456	89..513	CDD:215250	317/423 (75%)
kdn	NP_727091.1	ScCit1-2_like	92..519	CDD:99858	321/426 (75%)
cs	NP_955892.1	PLN02456	7..456	CDD:215250	318/426 (75%)
cs	NP_955892.1	ScCit1-2_like	35..462	CDD:99858	321/426 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592700
Domainoid	1	1.000	617	1.000	Domainoid score	I177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56073
Inparanoid	1	1.050	676	1.000	Inparanoid score	I698
OMA	1	1.010	-	-		QHG54065
OrthoDB	1	1.010	-	-		D1131452at2759
OrthoFinder	1	1.000	-	-		FOG0002348
OrthoInspector	1	1.000	-	-		oto40577
orthoMCL	1	0.900	-	-		OOG6_101425
Panther	1	1.100	-	-	LDO	PTHR11739
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2070
SonicParanoid	1	1.000	-	-		X2045
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940