DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kdn and Cs

DIOPT Version :9

Sequence 1:	NP_727091.1	Gene:	kdn / 31579	FlyBaseID:	FBgn0261955	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_080720.1	Gene:	Cs / 12974	MGIID:	88529	Length:	464	Species:	Mus musculus

Alignment Length:	438	Identity:	320/438 - (73%)
Similarity:	371/438 - (84%)	Gaps:	0/438 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 RMIAADGKSLRDVLAAKVPQEQERVKNFRKQHGATKMGETTIDMMYGGMRGIKALVTETSVLDAD 147
            |..:|...:|:|||:..:|:||.|:|.|::|||.|.:|:.|:|||||||||:|.||.||||||.|
Mouse    24 RHASASSTNLKDVLSNLIPKEQARIKTFKQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPD 88

  Fly   148 EGIRFRGLSIPECQKVLPAADGGTEPLPEGLFWLLLTGEVPTKSQVQQLSREWAERAALPQHVVT 212
            |||||||.|||||||:||.|.||.|||||||||||:||::||:.||..||||||:|||||.||||
Mouse    89 EGIRFRGYSIPECQKMLPKAKGGEEPLPEGLFWLLVTGQMPTEEQVSWLSREWAKRAALPSHVVT 153

  Fly   213 MLNNMPTTLHPMSQFAAAVTALNHDSKFAKAYSDGVHKSKYWEYVYEDSMDLIAKLPVVAATIYC 277
            ||:|.||.||||||.:||:||||.:|.||:||::|::::||||.:|||.||||||||.|||.||.
Mouse   154 MLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGMNRAKYWELIYEDCMDLIAKLPCVAAKIYR 218

  Fly   278 NTYRGGKGSRSIDSSLDWSANFVKMLGYDNAPFTELMRLYLTIHSDHEGGNVSAHTVHLVGSALS 342
            |.||.|....:|||.||||.||..||||.:..||||||||||||||||||||||||.||||||||
Mouse   219 NLYREGSSIGAIDSRLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALS 283

  Fly   343 DPYLSFAAGLNGLAGPLHGLANQEVLVWLRKLQKEAGNNPSEEQLKEYIWKTLKSGQVVPGYGHA 407
            ||||||||.:|||||||||||||||||||.:||||.|.:.|:|:|::|||.||.||:||||||||
Mouse   284 DPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHA 348

  Fly   408 VLRKTDPRYTCQREFALKHLPEDETFQLVSKIYKVVPPILTETGKVKNPWPNVDAHSGVLLQYYG 472
            |||||||||:|||||||||||:|..|:||:::||:||.||.|.||.|||||||||||||||||||
Mouse   349 VLRKTDPRYSCQREFALKHLPKDPMFKLVAQLYKIVPNILLEQGKAKNPWPNVDAHSGVLLQYYG 413

  Fly   473 MKEMNYYTVLFGVSRALGVLASLVWDRALGLPIERPKSFSTDLLVKMV 520
            |.|||||||||||||||||||.|:|.||||.|:|||||.|||.|:|.|
Mouse   414 MTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMKFV 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kdn	NP_727091.1	PLN02456	89..513	CDD:215250	312/423 (74%)
kdn	NP_727091.1	ScCit1-2_like	92..519	CDD:99858	316/426 (74%)
Cs	NP_080720.1	PLN02456	29..454	CDD:215250	312/424 (74%)
Cs	NP_080720.1	ScCit1-2_like	33..459	CDD:99858	316/425 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847438
Domainoid	1	1.000	609	1.000	Domainoid score	I193
eggNOG	1	0.900	-	-		E1_COG0372
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56073
Inparanoid	1	1.050	671	1.000	Inparanoid score	I735
Isobase	1	0.950	-	0	Normalized mean entropy	S189
OMA	1	1.010	-	-		QHG54065
OrthoDB	1	1.010	-	-		D1131452at2759
OrthoFinder	1	1.000	-	-		FOG0002348
OrthoInspector	1	1.000	-	-		otm43140
orthoMCL	1	0.900	-	-		OOG6_101425
Panther	1	1.100	-	-	LDO	PTHR11739
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2070
SonicParanoid	1	1.000	-	-		X2045
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750