DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3842 and RDH14

DIOPT Version :9

Sequence 1:	NP_001259270.1	Gene:	CG3842 / 31576	FlyBaseID:	FBgn0029866	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_065956.1	Gene:	RDH14 / 57665	HGNCID:	19979	Length:	336	Species:	Homo sapiens

Alignment Length:	319	Identity:	152/319 - (47%)
Similarity:	191/319 - (59%)	Gaps:	20/319 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 MWLLRKCIQGPAYRKANR------IDGKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCE 112
            :||..:...||..::..|      :.||.|::||.|:|:|:.|..||.:.||||.|.|||..|.|
Human    17 LWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAE 81

  Fly   113 AARLDIMDRSRNQ-------------QLFNRTLDLGSLQSVRNFVERFKAEESRLDILINNAGVM 164
            .|...:....|..             :|..|.|||.||:|||.|.:....||.|||:||||||:.
Human    82 EAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIF 146

  Fly   165 ACPRTLTADGFEQQFGVNHLGHFLLTNLLLDRLKHSSPSRIVVVSSAAHLFGRINREDLMSEKNY 229
            .||...|.||||.|||||||||||||||||..||.|:|||||||||..:.:|.||.:||.||::|
Human   147 QCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSY 211

  Fly   230 SKFFGAYSQSKLANILFTLKLSTILKDTGVTVNCCHPGVVRTEINRHFSGPGWMKTALQKGSLYF 294
            :|.| .||:|||||||||.:|:..|:.|.||||..|||:|||.:.||...|..:|......|..|
Human   212 NKSF-CYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAF 275

  Fly   295 FKTPKAGAQTQLRLALDPQLEGSTGGYYSDCMRWPLFPWVRNMQTADWLWRESEKLLGL 353
            ||||..||||.:.||..|::||.:|.|:.||....|.|...:...|..||..||.::||
Human   276 FKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3842	NP_001259270.1	FabG	71..319	CDD:223959	135/266 (51%)
CG3842	NP_001259270.1	NADB_Rossmann	74..347	CDD:304358	143/285 (50%)
RDH14	NP_065956.1	retinol-DH_like_SDR_c	43..328	CDD:212495	143/285 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75139
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750