DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3842 and RDH13

DIOPT Version :9

Sequence 1:	NP_001259270.1	Gene:	CG3842 / 31576	FlyBaseID:	FBgn0029866	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001139443.1	Gene:	RDH13 / 112724	HGNCID:	19978	Length:	331	Species:	Homo sapiens

Alignment Length:	314	Identity:	150/314 - (47%)
Similarity:	192/314 - (61%)	Gaps:	9/314 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LLRKCIQGPAYRKANRIDGKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIMD 120
            ||:..:.|.|......|.||.|||||.||||||:|.||||:||..:.:||||..:||||..||..
Human    20 LLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRG 84

  Fly   121 RSRNQQLFNRTLDLGSLQSVRNFVERFKAEESRLDILINNAGVMACPRTLTADGFEQQFGVNHLG 185
            .:.|..:..|.|||.||:|:|.|..:...||.|:||||||||||.||...|.||||.||||||||
Human    85 ETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLG 149

  Fly   186 HFLLTNLLLDRLKHSSPSRIVVVSSAAHLFGRINREDLMSEKNYSKFFGAYSQSKLANILFTLKL 250
            ||||||||||:||.|:||||:.:||.||:.|.|:.:||..:........||.|||||.:|||.:|
Human   150 HFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKEL 214

  Fly   251 STILKDTGVTVNCCHPGVVRTEINRH--FSGPGWMKTALQKGSLYFF--KTPKAGAQTQLRLALD 311
            |..|:.:|||||..||||.|||:.||  ..|..:..|.|  |.:::.  |:|:..||....||:.
Human   215 SRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTL--GPIFWLLVKSPELAAQPSTYLAVA 277

  Fly   312 PQLEGSTGGYYSDCMRWPLFPWVRNMQTADWLWRESEKLLGLPPLEPPPPVQSP 365
            .:|...:|.|:....:....|...:.:.|..||.||.:|:|   ||.|...:.|
Human   278 EELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVG---LEAPSVREQP 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3842	NP_001259270.1	FabG	71..319	CDD:223959	132/251 (53%)
CG3842	NP_001259270.1	NADB_Rossmann	74..347	CDD:304358	137/276 (50%)
RDH13	NP_001139443.1	retinol-DH_like_SDR_c	38..313	CDD:212495	137/276 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760